The classical complement pathway is one of three pathways which activate the complement system, which is part of the immune system. The classical complement...

The alternative pathway is a type of cascade reaction of the complement system and is a component of the innate immune system, a natural defense against...

biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway. The alternative...

formation can occur in three different pathways: the classical, lectin, and alternative pathways. Cleavage of complement C3 by a free floating convertase,...

here – classical complement pathway). In brief, the crucial role of C1q in the pathway is its importance as the first protein to start the complement cascade...

lectin pathway or MBL pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, in that...

the classical complement pathway of the complement system. The antibodies IgM and all IgG subclasses except IgG4 are able to initiate the complement system...

(complement component 1, C1) is a protein complex involved in the complement system. It is the first component of the classical complement pathway and...

response. Different complement receptors can participate in either the classical complement pathway, the alternative complement pathway, or both. White blood...

the brain. Apo-E qualifies as a checkpoint inhibitor of the classical complement pathway by complex formation with activated C1q. Apolipoproteins are...

the C1s enzyme and inhibits its enzymatic propagation of the classical complement pathway, thereby, preventing the formation of the C3-convertase enzyme...

isotype antibodies also bind. In addition, CRP activates the classical complement pathway via C1q binding. CRP thus forms immune complexes in the same...

target muscle and skin antigens, leading to the activation of the classical complement pathway, ultimately forming the membrane attack complex (MAC) on the...

or loss of function through mechanisms such as complement activation via the classical complement pathway Antibody-dependent cellular cytotoxicity or anti-receptor...

to C1q, but IgA cannot, therefore IgA does not activate the classical complement pathway. Another role of the Fc region is to selectively distribute different...

concentrations of ATG can induce lysis of T lymphocytes through the classical complement pathway along with B cell and NK cell depletion as well . Thymoglobulin...

on target cell (e.g. bacterial or viral infected cell), the classical complement pathway is triggered by bonding protein C1q to these antibodies, resulting...

as skin, joints, vessels, or glomeruli, and trigger the classical complement pathway. Complement activation leads to the recruitment of inflammatory cells...

other immunoglobulins (IgG or IgM). Early components of the classical complement pathway (C1q or C4) are usually not seen. Electron microscopy confirms...

covalently to somatic cells, as a result of activation of the classical complement pathway. They appear potentially useful for the diagnosis of systemic...

Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system...

efficient activator of pro-inflammatory responses by triggering the classical complement pathway. It has the shortest half-life compared to the other IgG subclasses...

pathways activate the complement system: the classical complement pathway, the alternate complement pathway, and the mannose-binding lectin pathway....

Penicillin (high dose) Quinidine (IgM mediated activation of classical complement pathway and Membrane attack complex, MAC) (A memory device to remember...

or the alternative pathway (C3bBbC3b) of complement system. Two fluid phase C5 convertases have been described: the classical pathway enzyme, C4b2boxy3b...

tests the classical complement pathway and thus requires functioning C1-C9 factors. If an individual has deficient or malfunctioning complement factors...

activation of the complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency...

bacterial capsular swelling and phagocytosis, and activates the classical complement pathway through its calcium-dependent binding to phosphocholine. CRPs...

the alternative pathway as insects do not possess adaptive immunity. Therefore, unlike the classical complement pathway the TEP1 pathway is antibody independent...

the classical complement pathway leading to complement mediated hemolysis of RBCs in RE system. Rarely, a biphasic IgG antibody leads to complement mediated...