• Thumbnail for Complement factor I
    Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. Complement factor I (factor I) is a protein...
    18 KB (2,240 words) - 16:09, 17 July 2025
  • Thumbnail for Complement system
    of complement component 3, complement factor B, and complement factor I, as well as deletion of complement factor H-related 3 and complement factor H-related...
    43 KB (5,123 words) - 16:58, 16 July 2025
  • Thumbnail for Complement factor B
    Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway...
    9 KB (1,095 words) - 16:58, 16 July 2025
  • Factor I may refer to: Complement factor I, a protein of the complement system Fibrinogen, a protein involved in blood coagulation Factor 1, a component...
    226 bytes (61 words) - 05:10, 12 May 2024
  • Thumbnail for Alternative complement pathway
    called complement factor I cleaves C3b into its inactive form, iC3b. Factor I requires a C3b-binding protein cofactor such as complement factor H, CR1...
    7 KB (865 words) - 03:25, 26 May 2025
  • Thumbnail for Factor H
    Factor H (FH) is a soluble glycoprotein and a member of the regulators of complement activation (RCA) family. It functions as a complement control protein...
    31 KB (3,694 words) - 05:47, 19 July 2025
  • Thumbnail for Factor D
    Factor D (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) is a protein...
    18 KB (2,047 words) - 23:18, 16 August 2023
  • IC3b (category Complement system)
    complement factor I cleaves C3b. Complement receptors on white blood cells are able to bind iC3b, so iC3b functions as an opsonin. Unlike intact C3b, iC3b cannot...
    788 bytes (100 words) - 16:02, 1 July 2019
  • Thumbnail for Complement component 3
    agent. Factor I can cleave C3b into C3c and C3d, the latter of which plays a role in enhancing B cell responses. In the alternative complement pathway...
    15 KB (1,758 words) - 16:58, 16 July 2025
  • Thumbnail for Hemolytic–uremic syndrome
    for several complement regulatory proteins. Later, mutations in complement factor H, complement factor I, membrane cofactor protein, factor B, C3, and...
    56 KB (5,766 words) - 09:09, 19 July 2025
  • Thumbnail for Chromosome 4
    encoding protein Cytokine dependent hematopoietic cell linker Complement Factor I: Complement Factor I COL25A1-DT: encoding protein Zinc finger, cchc domain containing...
    31 KB (1,931 words) - 05:25, 19 July 2025
  • Thumbnail for Complement 3 deficiency
    Molecular Basis of Primary Deficiencies of Complement Component C3 and its Regulatory Proteins Factor I and Factor H". Scandinavian Journal of Immunology...
    8 KB (828 words) - 23:36, 24 September 2024
  • to complement regulator I protein. It is responsible for the clumping of blood plasma observed when adding S. aureus to human plasma. Clumping factor can...
    1 KB (106 words) - 11:16, 23 May 2021
  • Thumbnail for C3-convertase
    of complement activation. After cleavage and binding to cell surface, the C3b fragment is ready to bind a plasma protein called Factor B. The Factor B...
    10 KB (1,319 words) - 01:19, 29 November 2024
  • Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system...
    35 KB (4,189 words) - 16:09, 17 July 2025
  • Thumbnail for C3a (complement)
    regulated without C3b inactivation, through complement control proteins, including decay-accelerating factors that function to speed up C3 convertase half-lives...
    17 KB (2,036 words) - 05:36, 19 February 2024
  • global brokerage firm CFI, a human gene that encodes the protein complement factor I Color Fidelity Index, a measure for color rendering developed by...
    2 KB (312 words) - 08:34, 8 April 2025
  • Thumbnail for Complement component 2
    It is also important to note that Complement component 2 deficiency can be caused by genetic and environmental factors. In genetic inheritance, Autosomal...
    16 KB (2,068 words) - 16:58, 16 July 2025
  • failure, and death. The complement system activation may be due to mutations in the complement regulatory proteins (factor H, factor I, or membrane cofactor...
    38 KB (4,172 words) - 15:45, 17 July 2025
  • Thumbnail for Decay-accelerating factor
    Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. DAF regulates the complement...
    8 KB (962 words) - 17:05, 16 July 2025
  • Macrophage-1 antigen (or integrin αMβ2 or macrophage integrin or Mac-1) is a complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin...
    9 KB (1,147 words) - 01:46, 25 November 2024
  • Thumbnail for Properdin
    Properdin (redirect from Factor P)
    humans is encoded by the CFP (complement factor properdin) gene. Properdin is plasma glycoprotein that activates the complement system of the innate immune...
    3 KB (418 words) - 15:28, 7 May 2025
  • Thumbnail for Macular degeneration
    CC, Witteman JC, Bergen AA, Kardys I, de Maat MP, et al. (July 2006). "Complement factor H polymorphism, complement activators, and risk of age-related...
    91 KB (9,880 words) - 23:19, 2 August 2025
  • Thumbnail for C1QBP
    Complement component 1 Q subcomponent-binding protein, mitochondrial is a protein that in humans is encoded by the C1QBP gene. The human complement subcomponent...
    13 KB (1,621 words) - 15:53, 17 July 2025
  • Willebrand factor, type C (VWFC or VWC)is a protein domain is found in various blood plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains);...
    5 KB (577 words) - 06:46, 2 June 2025
  • Thumbnail for Complement component 1s
    Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system...
    10 KB (1,195 words) - 16:58, 16 July 2025
  • Thumbnail for Complement receptor 1
    of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane...
    22 KB (2,904 words) - 16:58, 16 July 2025
  • affecting complement activation and inflammation in AMD. His work further revealed that the AMD-associated 402H variant of complement factor H binds less...
    14 KB (1,510 words) - 20:23, 21 July 2025
  • 611721; PSAP Complement component 4, partial deficiency of; 120790; C1NH Complement factor H deficiency; 609814; HF1 Complement factor I deficiency; 610984;...
    234 KB (18,877 words) - 18:07, 24 March 2025
  • Thumbnail for Iptacopan
    treatment of paroxysmal nocturnal hemoglobinuria and proteinuria. It is a complement factor B inhibitor that was developed by Novartis. It is taken by mouth....
    15 KB (1,004 words) - 06:05, 22 June 2025