DNA end resection, also called 5′–3′ degradation, is a biochemical process where the blunt end of a section of double-stranded DNA (dsDNA) is modified...

distances to known points DNA end resection, the process of cutting away the 5′ side of a blunt end of double-stranded DNA This disambiguation page lists...

damaged DNA sites is independent of double-strand break repair. Plos one, 13(12), e0209594. Mimitou EP, Symington LS (September 2009). "DNA end resection: Many...

cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells". J. Biol. Chem. 289 (39): 27314–26. doi:10.1074/jbc...

LJ, Cejka P, Croteau DL, Bohr VA (2016). "RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks". Cell Rep. 16 (1): 161–73. doi:10.1016/j...

starts with the key end resection factor CtlP, which mediates the end resection of DSBs, resulting in the formation of a 3' ssDNA extension. Meditated...

vivo and may serve to tether broken ends prior to repair by non-homologous end joining or to initiate DNA end resection prior to repair by homologous recombination...

recruitment of 53BP1 in G1 cells directs DNA double-strand break repair to BRCA1/CtIP-mediated DNA-end resection". Aging. 12 (24): 24872–24893. doi:10.18632/aging...

cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells". J. Biol. Chem. 289 (39): 27314–26. doi:10.1074/jbc...

LJ, Cejka P, Croteau DL, Bohr VA (2016). "RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks". Cell Rep. 16 (1): 161–73. doi:10.1016/j...

called resection. In the strand invasion step that follows, an overhanging 3' end of the broken DNA molecule then "invades" a similar or identical DNA molecule...

Stephen P. (10 September 2010). "RETRACTED: Human SIRT6 promotes DNA end resection through CtIP deacetylation". Science. 329 (5997): 1348–1353. Bibcode:2010Sci...

coiled-coil sequences. Proteins of this family are DNA-binding proteins and are involved in DNA end resection and bridging at double-strand breaks. Sae2 has...

cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells". J. Biol. Chem. 289 (39): 27314–26. doi:10.1074/jbc...

component of the nucleosome remodeling and deacetylase complex NuRD. DNA end resection is a pivotal step in HRR repair that produces 3’ overhangs that provide...

Stephen P. (10 September 2010). "RETRACTED: Human SIRT6 promotes DNA end resection through CtIP deacetylation". Science. 329 (5997): 1348–1353. Bibcode:2010Sci...

2013). "Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian...

Jackson, Stephen P. (2010-09-10). "RETRACTED: Human SIRT6 promotes DNA end resection through CtIP deacetylation". Science. 329 (5997): 1348–1353. Bibcode:2010Sci...

NHEJ core factors such as Ku protein, DNA-PK, or Ligase IV. In MMEJ, repair of the DSB is initiated by end resection by the MRE nuclease, leaving single...

Hollingsworth, Nancy M.; Haber, James E. (October 2004). "DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1". Nature...

Dhere VR, Nabeta GN, et al. (August 2017). "SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination". Cell Reports. 20 (8):...

Khaliqdina F, Sharma AK, Ismail IH (March 2022). "BMI-1 regulates DNA end resection and homologous recombination repair". Cell Reports. 38 (12): 110536–61...

of the double-strand break to yield 3’ single-stranded DNA tails (a process called end resection). Next the Rad51 protein binds to these tails and initiates...

referred to as end resection. When RECQL4 is deficient, end resection, and thus HR, is reduced. Evidence suggests that other forms of DNA repair including...

scientific contributions include the structural and molecular mechanism of DNA end resection by RecBCD (E. coli) and DNA2-Sgs1-RPA and regulatory stimulation by...

techniques, including endoscopic mucosal resection or endoscopic submucosal dissection. Endoscopic resection is possible if there is a low possibility...

ligase/polymerase/nuclease (3'-phosphoesterase) found in bacterial non-homologous end joining (NHEJ) DNA repair systems. It is much more error-prone than the more complex...

tumor DNA (ctDNA) is tumor-derived fragmented DNA in the bloodstream that is not associated with cells. ctDNA should not be confused with cell-free DNA (cfDNA)...

Baer R, Lukas J, Jackson SP (November 2007). "Human CtIP promotes DNA end resection". Nature. 450 (7169): 509–14. Bibcode:2007Natur.450..509S. doi:10...

patients (44) (45) (46). Identification of new factors inhibiting DNA end resection, REV7 (47) and HELB (48), contributing to drug resistance in a mouse...