function of this protein, leading to site-specific trinucleotide expansions. Flap structure-specific endonuclease 1 has been shown to interact with: APEX1...

Flap endonucleases (FENs, also known as 5' durgs in older references) are a class of nucleolytic enzymes that act as both 5'-3' exonucleases and structure-specific...

typically called restriction endonucleases or restriction enzymes, cleave only at very specific nucleotide sequences. Endonucleases differ from exonucleases...

nucleotide is displaced into a flap and subsequently removed by FEN1. Dna2 endonuclease does not have a specific structure and their properties are not...

pair mismatches. For details see flap endonuclease. There are more than 900 restriction enzymes, some sequence specific and some not, have been isolated...

Research. 11 (2 Pt 1): 473–82. doi:10.1158/1078-0432.473.11.2. PMID 15701830. Wang K, Xie C, Chen D (May 2014). "Flap endonuclease 1 is a promising candidate...

creating a short flap that is directly removed by flap structure-specific endonuclease 1 (FEN-1), which cleaves the 5’ overhanging flap. This method is...

approach generally known as Taq-MAMA. Flap endonuclease (FEN) is an endonuclease that catalyzes structure-specific cleavage. This cleavage is highly sensitive...

CEBPA, Cyclin A1, Cyclin E1, Flap structure-specific endonuclease 1, ORC1L, P21, PPM1B, PPP2CA, Retinoblastoma-like protein 1, Retinoblastoma-like protein...

the 5' is transformed into a "flap intermediate" causing it to be "displaced". FEN1 (flap structure-specific endonuclease 1), a nuclease, removes the displaced...

DNMT1 EP300 Establishment of Sister Chromatid Cohesion 2 Flap structure-specific endonuclease 1 GADD45A GADD45G HDAC1 HUS1 ING1 KCTD13 KIAA0101 Ku70 Ku80...

(Transportin-1) resulting in nuclear localization of hnRNPA1. hnRNP A1 has been shown to interact with BAT2, Flap structure-specific endonuclease 1 and IκBα...

same protein. APEX1 has been shown to interact with MUTYH, Flap structure-specific endonuclease 1 and XRCC1. Deficiency of APEX1 causes accummulation of DNA...

"The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities". J. Biol. Chem. 274 (53): 37763–9...

plasmids that use the rolling circle replication (RCR) mechanism, the RCR endonuclease creates a nick in the genome strand (single stranded viruses) or one...

to copy the undamaged strand via translocation. DNA ligase I and Flap endonuclease 1 or the Ligase-III-XRCC1 complex seal the nicks to complete NER. The...

unedited DNA sequence. The 5’ flap is then cleaved by structure-specific endonucleases or 5’ exonucleases. This process allows 3’ flap ligation, and creates a...

Bambara RA (April 2002). "Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate". J...

Yakovlev AG, Smulson ME (2000). "Genome Degradation by DNAS1L3 Endonuclease: A Key PARP-1-Regulated Event in Apoptosis". Madame Curie Bioscience Database...

flap. Pol β can also perform long-patch displacement synthesis. Long-patch synthesis typically inserts 2–10 new nucleotides. Then flap endonuclease removes...

junction endonuclease MUS81 is an enzyme that in humans is encoded by the MUS81 gene. In mammalian somatic cells, MUS81 and another structure specific DNA...

also involved in flap endonuclease activity, as detected in the context of inhibiting gene-editing nickases that generate an extension flap such as prime...

Symington LS (July 2009). "Breaking up just got easier to do". Cell. 138 (1): 20–22. doi:10.1016/j.cell.2009.06.039. PMID 19596231. S2CID 15429205. Kim...

pathway of fission yeast meiotic recombination in the absence of a DNA flap endonuclease". Genetics. 171 (4): 1499–511. doi:10.1534/genetics.105.046821. PMC 1456079...

strategies that control replication onset. Although the specific replication origin organization structure and recognition varies from species to species, some...

primers are then removed by nuclease enzymes, RNases H or Flap Structure-specific Endonuclease 1 (FEN1). As such, there is a fairly substantial volume of...

a homologous gene. 5' and 3' overhang flaps are cleaved and gaps are filled by the exonuclease and endonuclease activities of Pfu and taq DNA polymerases...

yeast), which are single-stranded DNA endonucleases,; mouse and human FEN-1, a structure-specific endonuclease; RAD2 from fission yeast and RAD27 from...

(BER) pathway. To repair interstrand crosslinks in eukaryotes, a 3’ flap endonuclease from the NER, XPF-ERCC1, is recruited to the crosslinked DNA, where...

to acetylate β-catenin, RIP140, PCNA, the DNA metabolic enzymes flap endonuclease-1, thymine DNA glycosylase, and Werner syndrome DNA helicase, STAT6...