G2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms that ensures that cells don't initiate mitosis until damaged...

the G2/M checkpoint transition. Similar to S Phase, G2 experiences a DNA damage checkpoint. The cell is once more examined for sites of DNA damage or incomplete...

cell cycle checkpoints, the other two being the G2-M DNA damage checkpoint and the spindle checkpoint. Originally, Howard Martin Temin showed that chicken...

vulnerable to DNA damage than any other part of the cell cycle. G2 checkpoint checks for damaged DNA and DNA replication completeness. Damage to DNA that occurs...

the damage before continuing to divide. DNA damage checkpoints occur at the G1/S and G2/M boundaries. An intra-S checkpoint also exists. Checkpoint activation...

G2-M DNA damage checkpoint M spindle checkpoint, prevents anaphase onset until all chromosomes are properly attached to the spindle Immune checkpoint...

G2. In particular, the G2 checkpoint arrests cells in G2 in response to DNA damage through inhibitory regulation of CDK1. During mitotic S phase, DNA...

phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response". Mol. Cell. Biol. 24 (20): 9207–20. doi:10.1128/MCB...

CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell...

single-stranded DNA tracts is important in initiating the checkpoint pathways downstream of replication damage. Once single-stranded DNA becomes sufficiently...

purpose for this checkpoint is to check for appropriate cell size and any DNA damage . The second check point is in the G2 phase, this checkpoint also checks...

checkpoints to ensure that damaged or incomplete DNA is not passed on to daughter cells. Three main checkpoints exist: the G1/S checkpoint, the G2/M checkpoint...

(Synthesis phase) is the phase of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase. Since accurate duplication of the genome is...

CDC2 unable to arrest in G2 in response to DNA damage, indicating the gene product is involved in G2 arrest. M: A mutant screen of budding yeasts with mitotic...

needed to replicate DNA are made. After G1, the cells enter S phase during which the DNA is replicated. After S, the cell will enter G2 where the proteins...

maintenance of DNA replication fork stability. In response to DNA damage, Chk1 is an important signal transducer for G2/M checkpoint activation. Activation...

suppression, DNA replication and embryonic development, HIV-1 "hijacks" the ubiquitin ligase complex to induce arrest of the cell cycle in G2 phase. The...

regulator of the Intra-S phase and the G2/M cell cycle checkpoints and recruits repair proteins to the site of DNA damage. It is involved in determining cell...

relicensing of replication origins and to activate cell cycle and DNA damage checkpoints. DNA rereplication must be strictly regulated to ensure that genomic...

alternative RFC (replacing RFC1 with Rad24) plays a role in the DNA damage checkpoint. The presence of an alternative RFC in the cohesion pathway can...

different DNA damage checkpoints, which inhibit the next or maintain the current cell cycle step. There are two main checkpoints, the G1/S and the G2/M, during...

two G0/G1 cells has the same total content of DNA and thus the same fluorescence intensity as a single G2/M cell. Unless recognized as such the G0/G1 doublets...

Carpenter PB, Bonner WM, Chen J, Nussenzweig A (Dec 2002). "DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1". Nature Cell Biology...

the cell grows, and the S phase, during which DNA is replicated. It is governed by cell cycle checkpoints to ensure cell cycle integrity and the subsequent...

include the G1 and G2 phases, DNA replication or S phase, and the actual process of cell division, mitosis or M phase. During the M phase, the chromosomes...

Carpenter PB, Bonner WM, Chen J, Nussenzweig A (Dec 2002). "DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1". Nature Cell Biology...

leads to the DNA damage checkpoint activation. The pathway of choice in DNA repair is highly regulated to guarantee that cells in the S/G2 and G1 phase...

are three checkpoints in the cell cycle: the G1/S Checkpoint or the Start checkpoint in yeast; the G2/M checkpoint; and the spindle checkpoint. During G1...

mechanisms of meiotic prophase I arrest and resumption and the mitotic G2 DNA damage checkpoint: CDC14B-based activation of APC-CDH1 in arrest and CDC25B-based...

material occurs properly, there are cellular checkpoints in place. The meiotic checkpoint network is a DNA damage response system that controls double strand...