A cancer-associated fibroblast (CAF) (also known as tumour-associated fibroblast; carcinogenic-associated fibroblast; activated fibroblast) is a cell type...

A fibroblast is a type of biological cell typically with a spindle shape that synthesizes the extracellular matrix and collagen, produces the structural...

ecosystem surrounding a tumor, composed of cancer cells, stromal tissue (including blood vessels, immune cells, fibroblasts and signaling molecules) and the extracellular...

epithelial cells in lymphatic vessels, and cancer-associated fibroblasts (i.e., fibroblasts located in cancer tissues). The binding of PLAG-3/PLAG-4 to...

microenvironment that inhibits immune detection and blocks anti-cancer immunity. Cancer associated fibroblasts secrete fibrous tissue (desmoplasia) consisting of matrix...

cell migration. For example, cancer- associated fibroblasts (CAFS) produce substances that remodel the ECM and promote cancer progression. Intravastation...

non-profit organisation Calcium fluoride (CaF 2), a chemical compound Cancer-associated fibroblast, a tumorous cell type Cellular angiofibroma, a benign tumor of...

(December 2009). "The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma". Cell Cycle. 8 (23): 3984–4001. doi:10...

Breast cancer is a cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling...

These include fibroblasts and endocrine cells. The symptoms of a sex-cord or stromal ovarian tumor can differ from other types of ovarian cancer. Common signs...

Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster...

Ghorani E, Munir H, Martins CP, Shields JD (March 2018). "Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect...

carcinoma of the head and neck and who have moderate or high cancer associated fibroblast (CAF) density tumours. This trial follows on from promising pre-clinical...

whose ligands are specific members of the fibroblast growth factor family. FGFR-1 has been shown to be associated with Pfeiffer syndrome, and clonal eosinophilias...

Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene. Prolyl endopeptidase...

Fibroblast growth factor 18 (FGF-18) is a protein that is encoded by the FGF18 gene in humans. The protein was first discovered in 1998, when two newly-identified...

Cholangiocarcinoma, also known as bile duct cancer, is a type of cancer that forms in the bile ducts. Symptoms of cholangiocarcinoma may include abdominal...

migrating tumor cells, mesenchymal (fibroblast-like) and amoeboid, can be observed in various patterns of cancer cell invasion. This article describes...

Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by the macrophages. They are involved in a wide variety of processes...

proliferation of keratinocytes, fibroblasts and other cells in the skin. Activation of other growth factor receptors such as fibroblast growth factor receptors...

be extrapolated to the cancer-associated fibroblasts which communicate with tumour cells via IL-6/STAT3 and this regulates cancer stem cell maintenance...

Fibroblast growth factor 8 (FGF-8) is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene belongs to the fibroblast...

Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene...

(January 2002). "Cancer cell-associated fibronectin induces release of matrix metalloproteinase-2 from normal fibroblasts". Cancer Research. 62 (1)....

can be suppressed by B cells regulation of TAM phenotypes. Cancer-associated fibroblasts (CAFs) have multiple TME functions, in part through extracellular...

to be significantly associated with nodal involvement and overall survival in patients with different types of cancer. Fibroblast growth factor receptor...

indicates a crucial role for the upregulation of FGFR2, part of the fibroblast growth factor receptor immunoglobin family, in cSCC cell progression....

function, leading to cirrhosis, liver failure, and liver cancer. The condition is strongly associated with or caused by type 2 diabetes, insulin resistance...

Worldwide, EBV infection is associated with 1% to 1.5% of all cancers. The vast majority of these EBV-associated cancers are LPD. The non-malignant, premalignant...

Distinct Mutational Profiles Including Oncogenic Fibroblast Growth Factor Receptor 3". Clinical Cancer Research. 23 (15): 4501–4510. doi:10.1158/1078-0432...