A chromosomal fragile site is a specific heritable point on a chromosome that tends to form a gap or constriction and may tend to break when the cell is...
21 KB (2,523 words) - 00:04, 21 December 2024
unusual "marker X chromosome" in association with intellectual disability. In 1970, Frederick Hecht coined the term "fragile site". And, in 1985, Felix...
59 KB (6,789 words) - 23:17, 17 July 2025
Causal fermion systems, a fundamental physics theory Chromosomal fragile site, a part of the chromosome prone to breakage Chronic fatigue syndrome, a chronic...
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simple crossover model, the two homologous chromosomes overlap on or near a common Chromosomal fragile site (CFS). This leads to a double-strand break...
12 KB (1,499 words) - 17:57, 16 July 2025
WWOX (category Genes on human chromosome 16)
Gardner A, Venter D, Baker E, Richards RI (Sep 2000). "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D...
12 KB (1,436 words) - 20:42, 18 July 2025
expression in the posterior fin bud. This enhancer is located near a chromosomal fragile site—a sequence of DNA that is likely to be broken and thus more likely...
53 KB (6,035 words) - 02:48, 17 March 2025
gene with brain-specific expression and also maps to an unstable chromosomal fragile site. The large gene instability hypothesis puts the DNA damage mechanism...
75 KB (9,007 words) - 12:41, 24 June 2025
neighbouring chromosomes. Minisatellites have been associated with chromosome fragile sites and are proximal to a number of recurrent translocation breakpoints...
9 KB (1,119 words) - 12:25, 4 March 2025
structures are present in higher density within and surrounding chromosomal fragile sites, which are segments of DNA that experience replication stress...
28 KB (3,447 words) - 16:00, 30 March 2024
Deletion (genetics) (redirect from Chromosomal deletion)
Causes include the following: Losses from translocation Chromosomal crossovers within a chromosomal inversion Unequal crossing over Breaking without rejoining...
14 KB (1,537 words) - 04:35, 17 July 2025
the Rankin et al., Strul et al., and Hsaio et al., the inherently fragile chromosome was stabilized by discovering the necessary autonomously replicating...
18 KB (1,982 words) - 19:00, 16 July 2025
Genome instability (category Chromosomes)
accumulation of extra copies of DNA or chromosomes, chromosomal translocations, chromosomal inversions, chromosome deletions, single-strand breaks in DNA...
38 KB (4,560 words) - 08:35, 19 June 2025
Professor in 2017. While at WCH, Sutherland's principal focus was on chromosomal fragile sites. Large family studies of genetic diseases revealed unexpected...
18 KB (1,808 words) - 15:53, 12 May 2025
Sex linkage (redirect from X chromosome disorders)
methylation status. Earlier cytogenetic methods, such as detecting "fragile sites" on the X chromosome, have largely been replaced due to low reliability, particularly...
91 KB (9,957 words) - 18:36, 16 July 2025
repeat protein 2 FOXP1: Forkhead Box Protein P1 FRA3A encoding protein Fragile site, aphidicolin type, common, fra(3)(p24.2) FRMD4B encoding protein FERM...
34 KB (1,991 words) - 05:25, 19 July 2025
Repeated sequence (DNA) (section Fragile X syndrome)
which protect the ends of chromosomal DNA from degradation. Repetitive elements are enriched in the middle of chromosomes as well. Centromeres are the...
32 KB (3,832 words) - 20:58, 13 April 2025
FHIT (redirect from Fragile histidine triad)
involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations...
6 KB (747 words) - 05:49, 19 July 2025
C3orf14 (redirect from C3orf14-Chromosome 3 open reading frame 14)
The human gene Chromosome 3 open reading frame 14 is a gene of uncertain function located at 3p14.2 near fragile site FRBA3—which falls between this gene...
8 KB (895 words) - 22:52, 2 December 2023
FMR1 (redirect from Fragile X mental retardation 1)
FMR1 (Fragile X Messenger Ribonucleoprotein 1) is a human gene that codes for a protein called fragile X messenger ribonucleoprotein, or FMRP. This protein...
28 KB (3,412 words) - 11:12, 9 July 2025
excision repair, cross-linking, alkali-labile sites, point mutations, and structural and numerical chromosomal aberrations. The compromised integrity of the...
29 KB (3,529 words) - 10:48, 12 July 2025
KIAA1109 (category Genes on human chromosome 4)
a function that is not yet understood. KIAA1109 has 3 aliases, FSA (fragile site-associated) protein, MGC110967 and DKFZp781P0474. An ortholog of KIAA1109...
16 KB (1,586 words) - 03:35, 20 July 2025
865 – trinucleotide repeat expansion MeSH G14.340.024.189.610 – chromosome fragile sites MeSH G14.340.024.220 – dna, intergenic MeSH G14.340.024.220.150...
33 KB (3,088 words) - 06:22, 19 July 2025
Chromomere Chromosomal crossover Chromosomal deletion Chromosome Chromosome aglet Chromosome banding Chromosome painting Chromosome region p Chromosome region...
33 KB (2,519 words) - 19:29, 23 July 2025
David L. Nelson (section Fragile X syndrome)
isolation of specific chromosomal regions, Nelson et al. identified chromosomal locations of large fragments of the human X chromosome; Nelson contributed...
33 KB (2,391 words) - 17:04, 16 July 2025
AFF2 (redirect from Fragile XE mental retardation)
is also known as FMR2 (Fragile Mental Retardation 2) after this condition. This gene is located on the long arm of chromosome X (Xq27.3-Xq28) It has 22...
9 KB (1,210 words) - 15:34, 17 July 2025
2021). "Biology before the SOS Response-DNA Damage Mechanisms at Chromosome Fragile Sites". Cells. 10 (9): 2275. doi:10.3390/cells10092275. ISSN 2073-4409...
28 KB (2,866 words) - 16:03, 23 May 2025
Basics | Wisconsin State Laboratory of Hygiene". "ISCN rules for listing chromosomal rearrangements". Current Protocols in Human Genetics. Appendix 4: Appendix...
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RNA 1 FMO3: flavin containing monooxygenase 3 FRA1J encoding protein Fragile site, 5-azacytidine type, common, fra(1)(q12) G0S2: encoding G0/G1 switch...
47 KB (3,307 words) - 21:26, 10 June 2025
Origin of replication (redirect from Replication origin site)
yeast and mammalian cells. Most bacterial chromosomes are circular and contain a single origin of chromosomal replication (oriC). Bacterial oriC regions...
113 KB (12,563 words) - 21:58, 15 June 2025
FRAXD (category Genes on human chromosome X)
symbol for fragile site, aphidicolin type, common, fra(X)(q27.2) D. The locus of the gene is located on fragile site of the q arm of chromosome X at position...
2 KB (109 words) - 20:55, 19 July 2025