• Thumbnail for ICAM-1
    ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene...
    19 KB (2,409 words) - 16:20, 11 December 2023
  • and monocytes. As of 2007, LFA-1 has 6 known ligands: ICAM-1, ICAM-2, ICAM-3, ICAM-4, ICAM-5, and JAM-A. LFA-1/ICAM-1 interactions have recently been...
    8 KB (946 words) - 18:38, 10 March 2023
  • Thumbnail for Intercellular adhesion molecule
    events. The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1...
    2 KB (156 words) - 10:59, 24 June 2024
  • Thumbnail for Ulcerative colitis
    specifically to the human ICAM-1 messenger RNA through Watson-Crick base pair interactions in order to subdue expression of ICAM-1. ICAM-1 propagates an inflammatory...
    143 KB (16,298 words) - 22:27, 29 May 2025
  • Thumbnail for Inflammatory bowel disease
    specifically to the human ICAM-1 messenger RNA through Watson-Crick base pair interactions in order to subdue expression of ICAM-1. ICAM-1 propagates an inflammatory...
    103 KB (11,366 words) - 12:28, 29 May 2025
  • Thumbnail for Addressin
    Addressin (redirect from MadCAM-1)
    It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1. Addressin is a lesser-used term to describe the group of adhesion...
    15 KB (1,785 words) - 06:26, 21 August 2024
  • Thumbnail for ICAM2
    ICAM2 (redirect from ICAM-2)
    by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like...
    10 KB (1,211 words) - 21:12, 5 April 2023
  • in cellular adhesion, binding to the intercellular adhesion molecule-1 (ICAM-1). CR3 causes phagocytosis and destruction of cells opsonized with iC3b...
    9 KB (1,147 words) - 01:46, 25 November 2024
  • Thumbnail for Alicaforsen
    therapeutic that targets the messenger RNA for the production of human ICAM-1 receptor and is being developed for the treatment of acute disease flares...
    17 KB (1,302 words) - 08:23, 7 November 2023
  • with ICAM-1 is achieved through the DBLβ domain adjacent to the head structure. However, many PfEMP1s having DBLβ domain do not bind to ICAM-1, and it...
    52 KB (6,604 words) - 10:36, 23 May 2025
  • Thumbnail for Leukocyte extravasation
    LFA-1 is found on circulating leukocytes, and binds ICAM-1 and ICAM-2 on endothelial cells Mac-1 is found on circulating leukocytes, and binds ICAM-1 on...
    27 KB (3,333 words) - 12:34, 12 December 2024
  • The Zicam name is derived from a portmanteau of the words "zinc" and "ICAM-1" (the receptor to which a rhinovirus binds in order to infect cells). It...
    16 KB (1,685 words) - 22:36, 29 May 2025
  • Thumbnail for Spermatogenesis
    adhesion molecules ICAM-1 and soluble ICAM-1 have antagonistic effects on the tight junctions forming the blood-testis barrier. ICAM-2 molecules regulate...
    34 KB (3,809 words) - 23:14, 23 May 2025
  • Thumbnail for VCAM-1
    Furthmayr H, Sanchez-Madrid F (Jun 2002). "Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent...
    6 KB (789 words) - 21:12, 7 December 2024
  • Thumbnail for Poly (ADP-ribose) polymerase
    expression of inflammatory genes: PARP1 is required for the induction of ICAM-1 gene expression by cardiac myocytes and smooth muscle cells, in response...
    25 KB (3,104 words) - 05:51, 28 March 2025
  • Thumbnail for Inflammation
    Cytokines also induce the expression of integrin ligands such as ICAM-1 and VCAM-1 on endothelial cells, which mediate the adhesion and further slow...
    96 KB (9,751 words) - 10:45, 15 May 2025
  • Thumbnail for Integrin alpha L
    intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory...
    10 KB (1,239 words) - 08:31, 10 June 2024
  • Thumbnail for Eosinophil
    bone marrow by lining vessel walls with adhesion molecules such as VCAM-1 and ICAM-1. When eosinophils are activated, they undergo cytolysis, where the breaking...
    29 KB (3,165 words) - 14:14, 27 March 2025
  • Thumbnail for List of therapeutic monoclonal antibodies
    pharmaceutical substances (INN): recommended INN: list 57". WHO Drug Information. 21 (1). hdl:10665/74004. World Health Organization (1998). "International nonproprietary...
    142 KB (4,345 words) - 21:22, 29 May 2025
  • Thumbnail for Common cold
    rhinovirus is typically acquired by direct contact; it binds to humans via ICAM-1 receptors and the CDHR3 receptor through unknown mechanisms to trigger the...
    58 KB (6,106 words) - 13:43, 20 April 2025
  • Upregulation of intercellular adhesion molecule-1 (ICAM-1) and cytokines associated with T-helper 1 immune response, may also play an important role...
    63 KB (7,080 words) - 19:14, 24 May 2025
  • interaction occurs between LFA-1 present in the p-SMAC of a T-cell, and non-specific adhesion molecules (such as ICAM-1 or ICAM-2) on a target cell. When bound...
    15 KB (1,808 words) - 07:15, 24 March 2025
  • Thumbnail for Golimumab
    protein (CRP) levels, interleukin (IL)-6, intercellular adhesion molecules (ICAM)-1, matrix metalloproteinase (MMP)-3, and vascular endothelial growth factor...
    14 KB (1,034 words) - 04:11, 24 January 2025
  • Thumbnail for Rhinovirus
    tract (mouth and nose). Rhinovirus A and B use "major" ICAM-1 (Inter-Cellular Adhesion Molecule 1), also known as CD54 (Cluster of Differentiation 54),...
    31 KB (3,449 words) - 18:27, 19 May 2025
  • best known for discovering the first integrins, LFA-1, and intercellular adhesion molecules (ICAMs), and for elucidating how these cell adhesion molecules...
    29 KB (2,150 words) - 18:05, 23 May 2025
  • endothelial cells express the adhesion molecules GlyCAM-1 (in mucosal HEV this is MAdCAM-1), ICAM-1 and CD34. They also secrete the chemokine CCL21. Naïve...
    10 KB (1,336 words) - 04:05, 26 March 2025
  • Thumbnail for Integrin beta 2
    lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1)". The Journal of Biological Chemistry...
    11 KB (1,299 words) - 10:15, 11 December 2023
  • Thumbnail for Sinusitis
    formulation of 0.73 mg of Tremacamra (a soluble intercellular adhesion molecule 1 [ICAM-1] receptor) reduced the severity of illness. A 2018 review has found that...
    82 KB (7,332 words) - 22:11, 29 May 2025
  • Thumbnail for Integrin
    formed by differential RNA splicing; for example, four variants of the beta-1 subunit exist. Through different combinations of the α and β subunits, 24...
    36 KB (3,928 words) - 22:54, 6 February 2025
  • Thumbnail for Endothelium
    characterized by the expression of molecules such as E-selectin, VCAM-1 and ICAM-1, which stimulate the adhesion of immune cells. Additionally, transcription...
    28 KB (3,076 words) - 04:38, 19 May 2025