Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three main classes of imidazoline receptor: I1...

it is now known that clonidine binds to imidazoline receptors with a much greater affinity than α2 receptors, which would account for its applications...

1016/S0022-3565(24)37390-2. PMID 9536007. Reis DJ, Piletz JE (1997). "The imidazoline receptor in control of blood pressure by clonidine and drugs". American Journal...

It acts as both a selective α2-adrenergic receptor antagonist, and an antagonist for the imidazoline receptor. Idazoxan has been under investigation as...

2-Imidazoline (Preferred IUPAC name: 4,5-dihydro-1H-imidazole) is one of three isomers of the nitrogen-containing heterocycle imidazoline, with the formula...

Moxonidine (INN) is a new-generation alpha-2/imidazoline receptor agonist antihypertensive drug licensed for the treatment of mild to moderate essential...

Rilmenidine is a imidazoline analog and shows greater selectivity for imidazoline receptors than for cerebral alpha2-adrenergic receptors, distinguishing...

hormone receptors are found in the nucleus, cytosol, and also on the plasma membrane of target cells. They are generally intracellular receptors (typically...

Catecholamines Cholinergic agonists and antagonists Heteroreceptor Imidazoline receptor Neuromuscular transmission Synaptic transmission Levitan, Irwin B...

In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain...

Efaroxan is an α2-adrenergic receptor antagonist and antagonist of the imidazoline receptor. The Darzens reaction between 2-fluorobenzaldehyde [57848-46-1]...

ATC code C02 Antihypertensives is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed...

their primary neurotransmitter, receptor or method of action. Many drugs act on more than one transmitter or receptor in the brain. Psychoactive drugs...

RAR-related orphan receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene. RORγ is a member of...

Tolonidine is an antihypertensive. It is an imidazoline receptor agonist, like moxonidine and rilmenidine. Clonidine Cosnier, D.; Duchene-Marullaz, P.;...

agmatinase. Agmatine binds to α2-adrenergic receptor and imidazoline receptor binding sites, and blocks NMDA receptors and other cation ligand-gated channels...

Voltage- gated Ca++ channel Synaptic vesicle Neurotransmitter transporter Receptor Neurotransmitter Axon terminal Synaptic cleft Dendrite A neurotransmitter...

used in glaucoma therapy. It is an α2 adrenergic receptor agonist and a weak α1 adrenergic receptor agonist.[citation needed] Topical apraclonidine is...

or placenta). Within those two classes are five types according to the receptors to which they bind: glucocorticoids and mineralocorticoids (both corticosteroids)...

examples are: Brimonidine Clonidine (mixed alpha2-adrenergic and imidazoline-I1 receptor agonist) Dexmedetomidine Fadolmidine Guanfacine, (preference for...

α2A-adrenergic receptor but also α2B- and α2C-adrenergic receptors and the imidazoline receptor. It is weaker than clonidine in producing hypotension and sedation...

pargyline has been found to bind with high affinity to the I2 imidazoline receptor. This receptor has been found to actually be an allosteric site on the monoamine...

acetylcholine receptor modulators Others: Imidazoline receptor modulators Purine receptor modulators Sigma receptor modulators Thyroid hormone receptor modulators...

is encoded by the NISCH gene. This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the inner layer of the plasma membrane...

bind with high affinity to the σ1 receptor (Ki = 3.2 nM) and with very high affinity to the I2 imidazoline receptor (Ki = 40 pM). Unlike selegiline, clorgiline...

effects appear on α adrenergic receptors, with little if any effect on β adrenergic receptors. Like other imidazolines, Oxymetazoline is readily absorbed...

Rilmenidine (imidazoline receptor agonist) Ganglion-blocking Mecamylamine (α3β4 nicotinic receptor antagonist) Trimethaphan (ganglion type receptor antagonist)...

candidate with a novel mechanism of action, acting as a ligand for the imidazoline receptor I2. It showed promising results in animal studies against various...

ingested the drug. There is no antidote for tetryzoline or other similar imidazoline analogue poisoning, but the symptoms can be alleviated. With treatment...

well-studied α2-adrenergic receptor antagonist in its structural family which does not antagonize any variant of the imidazoline receptor. It was shown to possess...