In immunology, peripheral tolerance is the second branch of immunological tolerance, after central tolerance. It takes place in the immune periphery (after...

site of induction, tolerance is categorized as either central tolerance, occurring in the thymus and bone marrow, or peripheral tolerance, taking place in...

marrow and T cells mature in the thymus. Central tolerance is not perfect, so peripheral tolerance exists as a secondary mechanism to ensure that T and...

and are released into the circulation. Additional mechanisms of peripheral tolerance exist to silence these cells, but if these fail, autoimmunity may...

Peripheral artery disease (PAD) is a vascular disorder that causes abnormal narrowing of arteries other than those that supply the heart or brain. PAD...

A malignant peripheral nerve sheath tumor (MPNST) is a form of cancer of the connective tissue surrounding peripheral nerves. Given its origin and behavior...

central tolerance mechanism in the thymus or better eliminate such self-reactive T cells on the other hand and thus contributing to peripheral tolerance – the...

Peripheral neuropathy, often shortened to neuropathy, refers to damage or disease affecting the nerves. Damage to nerves may impair sensation, movement...

regulatory T cells participating in peripheral immunity as a subset of CD4+ T cells. Tr1 cells regulate tolerance towards antigens of any origin. Tr1...

in peripheral tolerance against auto-reactive B lymphocytes include anergy, and antigen receptor desensitization. Like central tolerance, peripheral tolerance...

substances. This phenomenon involves the direct induction of peripheral lymphocyte tolerance. When an individual is in a state of anergy, it signifies that...

demyelinating polyneuropathy (CIDP) is an acquired autoimmune disease of the peripheral nervous system characterized by progressive weakness and impaired sensory...

of T cells. In regard to peripheral tolerance, peripheral tissue resting dendritic cells are able to promote self tolerance against cytotoxic T cells...

immune responses in the immune system. Tolerance can also be differentiated into "central" and "peripheral" tolerance, on whether or not the above-stated...

bloodstream or lymph nodes and serve mainly to confer tolerance to autoantigens. Induced (peripheral) T regulatory cells (iTregs, pTregs) arise under certain...

T-cell receptor, or TCR. Immune tolerance is maintained by central and peripheral tolerance. During central tolerance, T-cells are selected in the thymus...

in balance between tolerance and immune response. Tolerogenic DCs are essential in maintenance of central and peripheral tolerance through induction of...

for the induction of efferent CD8+ regulatory T cells needed for peripheral tolerance. EMR1 can serve as a therapeutic target for depletion of these cells...

PMC 1567700. PMID 16873544. Metzger, T.C. (2011). "Control of Central and Peripheral Tolerance by Aire". Immunological Reviews. 241 (1): 89–103. doi:10.1111/j.1600-065X...

activation of these T cells. Dendritic cells also play a role in peripheral tolerance, which contributes to prevention of auto-immune disease. Prior to...

be diagnosed by measuring hemoglobin A1c, fasting glucose, or glucose tolerance test. Many people may be diagnosed through routine screening tests. The...

The glucose tolerance test (GTT, not to be confused with GGT test) is a medical test in which glucose is given and blood samples taken afterward to determine...

adaptive immunity. They reside in the peripheral organs and induce different forms of antigen-specific peripheral tolerance. Antigens from the periphery are...

CTLs will not be activated in response to them due to central and peripheral tolerance mechanisms. When a cell expresses foreign proteins, such as after...

cause immune unresponsiveness to self-antigens via both central and peripheral tolerance. In the case of defective apoptosis, it may contribute to etiological...

anchor]. Both cTEC and mTEC participate in imposing central and peripheral tolerance. cTECs play a key role in the positive selection and mTECs eliminate...

may be one mechanism whereby peripheral tolerance is lost in SLE. Cluster of differentiation Co-stimulation Immune tolerance GRCh38: Ensembl release 89:...

expressing Tregs. Immune tolerance Central tolerance Peripheral tolerance regulatory T cells Immune response Immune tolerance in pregnancy Cobbold, S.;...

the growth and activation of self-reactive T cells and promotes peripheral tolerance. LRBA deficiency is inherited autosomal recessively and manifests...

strongly are induced to die. The second type of immunological tolerance is peripheral tolerance. Some self reactive T cells escape the thymus for a number...