Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded non-coding RNA molecules, typically...
60 KB (7,300 words) - 14:35, 22 July 2025
including piwi-interacting RNA (piRNA) and its subspecies repeat associated small interfering RNA (rasiRNA). Small RNA "is unable to induce RNAi alone...
18 KB (1,916 words) - 17:51, 18 July 2025
ribonucleic acid (RNA) molecules, microRNA (miRNA) and small interfering RNA (siRNA), are central to components to the RNAi pathway. Once mRNA is degraded,...
140 KB (15,435 words) - 18:06, 31 July 2025
rasi/piRNA biogenesis.) Double-stranded RNAs capable of silencing repeat elements, then known as repeat associated small interfering RNA (rasiRNA), were...
44 KB (5,243 words) - 05:19, 29 October 2024
Telomerase (section Small interfering RNA (siRNA))
means of interfering with telomerase in cancer cells. Most of the harmful cancer-related effects of telomerase are dependent on an intact RNA template...
50 KB (5,791 words) - 07:29, 19 July 2025
example is RNA interference (RNAi), in which endogenously expressed microRNA (miRNA) or exogenously derived small interfering RNA (siRNA) induces the...
48 KB (5,498 words) - 13:11, 28 December 2024
Inclisiran (category Small interfering RNA)
and heterozygous familial hypercholesterolemia (HeFH). It is a small interfering RNA (siRNA) that acts as an inhibitor of a proprotein convertase, specifically...
23 KB (1,937 words) - 11:44, 3 June 2025
levels. Using single-stranded RNA (ssRNA) fragments, such as microRNA (miRNA), or double-stranded small interfering RNA (siRNA), the complex functions as...
36 KB (3,842 words) - 17:13, 25 November 2024
RNA polymerase IV (RNAP IV) is an enzyme that synthesizes small interfering RNA (siRNA) in plants, which silence gene expression. RNAP IV belongs to a...
15 KB (1,820 words) - 15:32, 18 July 2025
triggers mRNA degradation by 5' decapping, 3' poly(A) tail removal, or endonucleolytic cleavage. In metazoans, small interfering RNAs (siRNAs) processed...
52 KB (6,275 words) - 14:39, 28 July 2025
Trans-acting siRNA (abbreviated "ta-siRNA" or "tasiRNA") are a class of small interfering RNA (siRNA) that repress gene expression through post-transcriptional...
9 KB (1,153 words) - 05:22, 31 January 2024
and regulate RNA modification. It has been observed that small interfering RNA (siRNA) and micro RNA (miRNA) are generally used as target RNA sequences,...
30 KB (3,629 words) - 22:56, 17 July 2025
Gene silencing (category RNA)
by an enzyme called Dicer. These small fragments, which include small interfering RNAs (siRNA) and microRNA (miRNA), are approximately 21–23 nucleotides...
49 KB (5,674 words) - 17:24, 16 July 2025
Zilebesiran (category Small interfering RNA)
being evaluated for the treatment of high blood pressure. It is small interfering RNA that is administered subcutaneously twice annually to lower blood...
7 KB (227 words) - 13:15, 21 January 2025
Lepodisiran (category Small interfering RNA)
Lepodisiran (LY3819469) is a small interfering RNA that was developed to reduce lipoprotein(a) in people at risk of cardiovascular disease. It was developed...
4 KB (208 words) - 15:45, 27 June 2025
Olpasiran (category Antisense RNA)
Olpasiran (AMG890) is an experimental siRNA (short interfering RNA) therapy designed to lower the level of lipoprotein(a), which is believed to be a causal...
2 KB (234 words) - 20:21, 28 June 2025
Antibodies Fitusiran: An investigational therapy that utilizes small interfering RNA (siRNA) technology to reduce antithrombin levels, thereby increasing...
23 KB (2,535 words) - 23:00, 17 July 2025
Natural antisense short interfering RNA (natsiRNA) is a type of siRNA. They are endogenous RNA regulators which are between 21 and 24 nucleotides in length...
3 KB (319 words) - 05:05, 31 January 2024
transfer RNA (tRNA), microRNA (miRNA), small interfering RNA (siRNA), small nucleolar RNA (snoRNAs), Piwi-interacting RNA (piRNA), tRNA-derived small RNA (tsRNA)...
66 KB (7,680 words) - 17:02, 22 July 2025
Patisiran (category Small interfering RNA)
is estimated to affect 50,000 people worldwide. It is the first small interfering RNA-based drug approved by the U.S. Food and Drug Administration (FDA)...
15 KB (952 words) - 21:49, 29 May 2025
Glossary of cellular and molecular biology (M–Z) (redirect from Uncharged tRNA)
in vitro or in vivo. small interfering RNA (siRNA) small nuclear RNA (snRNA) small nucleolar RNA (snoRNA) A class of small RNA molecules whose primary...
302 KB (26,849 words) - 21:18, 31 July 2025
nanoparticle RNA therapeutics for nucleic acid medicines including small interfering RNA (siRNA), messenger RNA (mRNA), gene editing RNA, DNA, antisense...
19 KB (1,801 words) - 02:20, 29 June 2025
ncRNAs from small non-coding RNAs, such as microRNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs)...
99 KB (10,625 words) - 11:19, 19 July 2025
Vutrisiran (category Small interfering RNA)
adults. It is a double stranded small interfering RNA (siRNA; also called RNA interference or RNAi therapeutic) that interferes with the expression of the...
26 KB (2,601 words) - 17:51, 28 July 2025
for the different types of RNA are listed and explained. List of cis-regulatory RNA elements RNA: Types of RNA Non-coding RNA Gribaldo S, Brochier-Armanet...
20 KB (1,022 words) - 07:09, 12 July 2025
double-stranded RNAs that function as small interfering RNA (siRNA) in the RNA silencing system. By sequestering siRNA, p19 suppresses RNA silencing and...
11 KB (1,172 words) - 03:13, 29 January 2023
Argonaute (category RNA-binding proteins)
as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs)...
17 KB (2,024 words) - 13:42, 17 July 2025
the mRNA. miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts...
147 KB (16,651 words) - 18:23, 28 July 2025
the gene silencing typically associated with small interfering RNAs (siRNAs) in RNA interference. saRNAs offer a novel approach to upregulate genes of...
19 KB (2,085 words) - 17:08, 23 July 2025
Nucleic acid (redirect from DNA and RNA)
biological nucleic acid molecules range in size from 21 nucleotides (small interfering RNA) to large chromosomes (human chromosome 1 is a single molecule that...
24 KB (2,848 words) - 22:04, 15 July 2025