• Thumbnail for Subtilisin
    Subtilisin is a protease (a protein-digesting enzyme) initially obtained from Bacillus subtilis. Subtilisins belong to subtilases, a group of serine proteases...
    12 KB (1,203 words) - 19:42, 29 August 2024
  • Thumbnail for PCSK9
    Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1. It is the 9th member of the proprotein...
    72 KB (7,711 words) - 04:35, 2 June 2025
  • Thumbnail for Serine protease
    categories based on their structure: chymotrypsin-like (trypsin-like) or subtilisin-like. The MEROPS protease classification system counts 16 superfamilies...
    22 KB (2,366 words) - 02:44, 31 May 2025
  • Thumbnail for Nattokinase
    (and should not be pronounced as such), but a serine protease of the subtilisin family (99.5% identical with aprE). Rather, it is named for the fact that...
    6 KB (644 words) - 23:38, 6 May 2025
  • Thumbnail for Proprotein convertase 1
    substrate). It is related to the bacterial enzyme known as subtilisin. There are nine subtilisin homologs in mammals; in addition to proprotein convertase...
    5 KB (600 words) - 15:33, 26 August 2023
  • Thumbnail for SSI protease inhibitor
    In molecular biology the protein SSI is a Subtilisin inhibitor-like which stands for Streptomyces subtilisin inhibitor. This is a protease inhibitor. These...
    4 KB (448 words) - 01:44, 10 June 2024
  • a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is a protein that targets LDL receptors for...
    18 KB (1,637 words) - 20:48, 29 May 2025
  • Thumbnail for Prion
    sp, subtilisin-like pernisine from Aeropyrum pernix, alkaline protease from Nocardiopsis sp, nattokinase from B. subtilis, engineered subtilisins from...
    104 KB (11,322 words) - 11:57, 31 May 2025
  • Thumbnail for Subtilase
    Subtilases are a family of subtilisin-like serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad...
    5 KB (645 words) - 22:56, 25 April 2024
  • Thumbnail for Boronic acid
    site serines and are part of inhibitors for porcine pancreatic lipase, subtilisin and the protease Kex2. Furthermore, boronic acid derivatives constitute...
    26 KB (2,605 words) - 19:58, 19 December 2024
  • Thumbnail for Coprophagia
    bacterial dysentery; its efficacy (probably attributable to the antibiotic subtilisin from Bacillus subtilis) was anecdotally confirmed by German soldiers in...
    23 KB (2,226 words) - 14:00, 3 June 2025
  • Thumbnail for Furin
    family S8, furin is a subtilisin-like peptidase. The protein encoded by this gene is an enzyme that belongs to the subtilisin-like proprotein convertase...
    17 KB (2,288 words) - 15:22, 19 March 2024
  • Thumbnail for PCSK5
    Proprotein convertase subtilisin/kexin type 5 is an enzyme that in humans is encoded by the PCSK5 gene, found in chromosome 9q21.3 Two alternatively spliced...
    8 KB (1,065 words) - 17:37, 21 May 2024
  • Thumbnail for Klenow fragment
    DNA polymerase I from E. coli is enzymatically cleaved by the protease subtilisin. First reported in 1970, it retains the 5' → 3' polymerase activity and...
    4 KB (473 words) - 22:46, 25 November 2024
  • Thumbnail for Bacillus licheniformis
    licheniformis one of the most important bacteria in industrial enzyme production. Subtilisin Carlsberg (P00780) secreted by B. licheniformis is used as a detergent...
    18 KB (1,854 words) - 21:19, 22 May 2025
  • Searching for "Subtilisin" returns the protein, "Subtilisin from Bacillus subtilis, carlsberg", with the following lineage. Subtilisin from Bacillus subtilis...
    22 KB (2,564 words) - 19:34, 16 August 2024
  • Thumbnail for PCSK6
    Proprotein convertase subtilisin/kexin type 6 is an protease that in humans is encoded by the PCSK6 gene which is located in chromosome 15. Pcsk6 is a...
    18 KB (2,148 words) - 18:47, 4 January 2024
  • Thumbnail for Catalytic triad
    Simultaneously, the structures of the evolutionarily unrelated papain and subtilisin proteases were found to contain analogous triads. The 'charge-relay' mechanism...
    58 KB (5,858 words) - 03:53, 26 May 2025
  • Thumbnail for List of biophysically important macromolecular crystal structures
    preventing the enzyme from sucking in the chain past the first residue. 1969 – Subtilisin (PDB file 1sbt ) was a second type of serine protease with a near-identical...
    23 KB (2,701 words) - 13:30, 24 January 2025
  • killer toxin precursors. The human homolog is PCSK4. It is a family of subtilisin-like peptidases. Even though there are a few prokaryote kexin-like peptidases...
    5 KB (504 words) - 22:17, 1 September 2023
  • Thumbnail for Proprotein convertase 2
    gene. It is related to the bacterial enzyme subtilisin, and altogether there are 9 different subtilisin-like genes in mammals: furin, PACE4, PC4, PC5/6...
    10 KB (1,274 words) - 04:35, 10 March 2025
  • Thumbnail for Proteolysis
    similar strategy of employing an inactive zymogen or prezymogen is used. Subtilisin, which is produced by Bacillus subtilis, is produced as preprosubtilisin...
    35 KB (4,339 words) - 14:45, 26 May 2025
  • Thumbnail for Taraxacum
    2019. Bogacheva AM, Rudenskaya GN, Preusser A, et al. (1999). "A new subtilisin-like proteinase from roots of the dandelion Taraxacum officinale Webb...
    53 KB (5,058 words) - 22:50, 3 June 2025
  • Thumbnail for Convergent evolution
    organisation of acid-base-nucleophile in different protease superfamilies. Shown are the triads of subtilisin, prolyl oligopeptidase, TEV protease, and papain....
    59 KB (5,817 words) - 19:16, 21 May 2025
  • Thumbnail for Protein
    Ottesen M, Richards FM (February 1955). "Degradation of ribonuclease by subtilisin". Biochimica et Biophysica Acta. 16 (2): 297–299. doi:10.1016/0006-3002(55)90224-9...
    105 KB (10,957 words) - 13:53, 25 May 2025
  • Thumbnail for Membrane-bound transcription factor site-1 protease
    factor site-1 protease, or site-1 protease (S1P) for short, also known as subtilisin/kexin-isozyme 1 (SKI-1), is an enzyme (EC 3.4.21.112) that in humans is...
    2 KB (342 words) - 16:52, 28 October 2022
  • Thumbnail for PCSK4
    Proprotein convertase subtilisin/kexin type 4 is an enzyme that in humans is encoded by the PCSK4 gene. GRCh38: Ensembl release 89: ENSG00000115257 – Ensembl...
    4 KB (572 words) - 23:33, 15 November 2022
  • Phytaspase is a member of the plant subtilisin-like protease family, and is commonly distinguished from the other members by its unusual and extremely...
    6 KB (688 words) - 06:13, 1 April 2025
  • Thumbnail for Proteinase K
    for its broad specificity. This enzyme belongs to Peptidase family S8 (subtilisin). The molecular weight of Proteinase K is 28,900 daltons (28.9 kDa). Activated...
    10 KB (1,063 words) - 20:45, 11 September 2024
  • domain at the N-terminus of peptidases belonging to MEROPS family S8A, subtilisins. The propeptide is removed by proteolytic cleavage; removal activating...
    20 KB (1,858 words) - 03:56, 20 October 2024