Thymic involution is the shrinking (involution) of the thymus with age, resulting in changes in the architecture of the thymus and a decrease in tissue...

thymic involution. After the first year of life the amount of T cells produced begins to fall. Fat and connective tissue fills a part of the thymic volume...

by the high levels of circulating sex hormones. Proportional to thymic size, thymic activity (T cell output) is most active before maturity. Upon atrophy...

relevant outcome. Thymus involution is probably the most relevant factor responsible for immunosenescence. Thymic involution is common in most mammals;...

including reduced lifespan, liver cancer, muscle atrophy, cataracts, thymic involution, haemolytic anemia, and a very rapid age-dependent decline in female...

rest of a male's adult life. Physical changes during puberty such as thymic involution also affect immunological response. Ecoimmunology, or ecological immunology...

(sarcopenia), early development of cataracts, macular degeneration, thymic involution, hepatocellular carcinoma, and shortened lifespan. Research suggests...

graying, hair loss, kyphosis (rounded upper back), osteoporosis and thymic involution. Furthermore, there are dramatic reductions with age in tissue-specific...

FGF21 protects against immune senescence by delaying age-related thymic involution". Proceedings of the National Academy of Sciences of the United States...

homeobox gene, HB24, inhibits development of CD4+ T cells and impairs thymic involution in transgenic mice". The Journal of Biological Chemistry. 268 (5):...

mouth, pharynx and the terminal part of the rectum (which are lined by involutions of the ectoderm), the lining cells of all the glands which open into...

but are a different T cell subset (Treg, regulatory T cells; RTE, Recent Thymic emigrant). The majority of human naive T cells are produced very early in...

thought to be the result of either a failure of descent or a failure of involution of normal thymus tissue. It may be diagnosed with radiology, such as an...