• Thumbnail for Alpha-1 antitrypsin
    Alpha-1 antitrypsin or α1-antitrypsin (A1AT, α1AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the SERPINA1...
    33 KB (3,410 words) - 19:54, 29 May 2025
  • Thumbnail for Alpha-1 antitrypsin deficiency
    Alpha-1 antitrypsin deficiency (A1AD or AATD) is a genetic disorder that may result in lung disease or liver disease. Onset of lung problems is typically...
    27 KB (2,912 words) - 21:05, 14 February 2025
  • Thumbnail for Serum protein electrophoresis
    albumin and the alpha-1 zone.[citation needed] Orosomucoid and antitrypsin migrate together but orosomucoid stains poorly so alpha 1 antitrypsin (AAT) constitutes...
    17 KB (2,212 words) - 18:02, 11 May 2025
  • Thumbnail for Panniculitis
    sarcoidosis with cutaneous involvement (seen in up to 20 percent); Alpha 1-antitrypsin deficiency Crohn's disease This is not a complete list of possible...
    12 KB (1,183 words) - 22:05, 22 July 2024
  • treat lung disease caused by alpha 1-antitrypsin deficiency. The active ingredient in the drug is the protein alpha-1 Antitrypsin (AAT). Glassia is indicated...
    7 KB (728 words) - 21:51, 13 March 2025
  • Thumbnail for Chronic obstructive pulmonary disease
    as dust from grains, cadmium dust or fumes, and genetics, such as alpha-1 antitrypsin deficiency. In developing countries, common sources of household...
    154 KB (16,633 words) - 20:21, 29 May 2025
  • Alpha 1 or Alpha-1 may refer to: Alpha-1 adrenergic receptor, a G protein-coupled receptor Alpha-1 antitrypsin, a protein Alpha-1 antitrypsin deficiency...
    764 bytes (138 words) - 10:58, 8 July 2024
  • Thumbnail for Emphysema
    develop with the effects of tobacco smoking and other risk factors. Alpha-1 antitrypsin deficiency is a genetic risk factor that may lead to the condition...
    43 KB (4,419 words) - 11:05, 24 May 2025
  • Thumbnail for Hepatitis
    causes of hepatitis include alpha-1-antitrypsin deficiency, hemochromatosis, and Wilson's disease. In alpha-1-antitrypsin deficiency, a co-dominant mutation...
    166 KB (16,950 words) - 04:51, 26 May 2025
  • Thumbnail for Serpin
    but it was not until the 1950s that the serpins antithrombin and alpha 1-antitrypsin were isolated, with the subsequent recognition of their close family...
    137 KB (14,375 words) - 02:07, 28 May 2025
  • medicine, protease inhibitor is often used interchangeably with alpha 1-antitrypsin (A1AT, which is abbreviated PI for this reason). A1AT is indeed the...
    20 KB (1,858 words) - 03:56, 20 October 2024
  • Thumbnail for Hypoalbuminemia
    suspected based on clinical suspicion, an alpha-1 antitrypsin test can be performed. If stool alpha-1 antitrypsin is elevated, this suggests excessive gastrointestinal...
    23 KB (2,560 words) - 12:43, 28 August 2024
  • Thumbnail for Alpha 1-antichymotrypsin
    amyloid-fibrils in this disease. Alpha 1-antichymotrypsin has been shown to interact with DNAJC1. Alpha-1 antitrypsin, another serpin that is analogous...
    4 KB (475 words) - 00:52, 10 September 2024
  • Thumbnail for Liver disease
    and Wilson's disease. Liver damage is also a clinical feature of alpha 1-antitrypsin deficiency and glycogen storage disease type II. In transthyretin-related...
    34 KB (3,337 words) - 22:52, 24 May 2025
  • Thumbnail for Dolly (sheep)
    gene for alpha 1-antitrypsin. The human gene was specifically activated in the ewe’s mammary gland, so Diana produced milk containing human alpha 1-antitrypsin...
    31 KB (2,923 words) - 19:41, 24 May 2025
  • Thumbnail for Cirrhosis
    copper in the liver Alpha-1 antitrypsin deficiency is an autosomal co-dominant disorder of low levels of the enzyme alpha-1 antitrypsin Cardiac cirrhosis...
    120 KB (12,524 words) - 13:49, 25 May 2025
  • Thumbnail for Bronchiectasis
    and recurrent lower respiratory tract infections. Individuals with alpha 1-antitrypsin deficiency have been found to be particularly susceptible to bronchiectasis...
    64 KB (6,716 words) - 21:52, 22 May 2025
  • Thumbnail for Focal lung pneumatosis
    sometimes be involved. Other conditions associated with lung bullae are: Alpha 1-antitrypsin deficiency Marfan syndrome Ehlers–Danlos syndromes Cocaine smoking...
    9 KB (780 words) - 23:07, 13 August 2024
  • Thumbnail for PAS diastase stain
    is also used to identify alpha-1 antitrypsin globules in hepatocytes, which is a characteristic finding of alpha-1 antitrypsin deficiency. PAS diastase...
    3 KB (295 words) - 12:29, 22 September 2024
  • Thumbnail for Alpha globulin
    HDL. α1-antitrypsin Alpha 1-antichymotrypsin Orosomucoid (acid glycoprotein) Serum amyloid A Alpha 1-lipoprotein Protein HC Haptoglobin Alpha-2u globulin...
    1 KB (119 words) - 19:37, 23 October 2023
  • Thumbnail for Neonatal jaundice
    intrahepatic cholestasis, bile duct paucity, Alagille syndrome, alpha 1-antitrypsin deficiency, and other pediatric liver diseases should be considered...
    31 KB (3,308 words) - 13:58, 23 May 2025
  • Thumbnail for Intellia Therapeutics
    candidates with potential applications in diseases including cancer, alpha-1 antitrypsin deficiency, and hemophilia. The company is also working on a variety...
    18 KB (1,662 words) - 16:31, 12 February 2025
  • Thumbnail for Fatty liver disease
    inflammatory bowel disease, HIV, hepatitis C (especially genotype 3), and alpha 1-antitrypsin deficiency The fatty change represents the intracytoplasmatic accumulation...
    38 KB (3,799 words) - 16:43, 10 May 2025
  • on obtaining Inhibrx's INBRX-101, an experimental treatment for Alpha-1 Antitrypsin Deficiency (AATD), an inherited rare disease that causes progressive...
    95 KB (9,124 words) - 22:07, 29 May 2025
  • Thumbnail for Neutrophil
    [citation needed] In alpha 1-antitrypsin deficiency, the important neutrophil elastase is not adequately inhibited by alpha 1-antitrypsin, leading to excessive...
    55 KB (5,866 words) - 12:36, 23 May 2025
  • Thumbnail for Orosomucoid
    alpha 1-acid glycoprotein levels where higher than those who's stay ended with death (1691 +/* 69 mg/l versus 1340 +/- 456 mg/l). Alpha-1 antitrypsin...
    16 KB (1,776 words) - 16:01, 23 May 2025
  • Thumbnail for Hep G2
    g., albumin, and the acute-phase proteins fibrinogen, alpha 2-macroglobulin, alpha 1-antitrypsin, transferrin and plasminogen.[citation needed] They have...
    5 KB (577 words) - 18:06, 6 May 2025
  • genetic liver disorder Alpha-1 antitrypsin deficiency (A1AD). His death increased awareness of this rare disorder, according to the Alpha-1 Foundation. "Brooke...
    7 KB (663 words) - 18:09, 15 May 2025
  • Thumbnail for Protein losing enteropathy
    quantifying protein loss in the bowel include faecal excretion of alpha 1-antitrypsin, a marker of protein losing enteropathy, as well as viral serologies...
    15 KB (1,647 words) - 19:30, 28 January 2025
  • Thumbnail for 23andMe
    Parkinson's disease, celiac disease, hereditary thrombophilia, alpha-1 antitrypsin deficiency, glucose-6-phosphate dehydrogenase deficiency, early-onset...
    77 KB (7,320 words) - 03:23, 31 May 2025