The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the...

prior to first dose, taking first dose at night (so avoiding falls, etc) and starting on low doses and titrating upwards. First pass effect Graham RM...

administration as well. In particular, the oral route is subject to a high first-pass effect, which results in high levels of testosterone in the liver and consequent...

rapid absorption, avoidance of first-pass metabolism, sustained plasma concentrations, and a local endometrial effect, while advantages of intravaginal...

high first-pass effect, which results in high levels of estradiol and consequent estrogenic effects in the liver and low potency due to first-pass hepatic...

administration are largely the same as with medicinal drugs: Bypassing the first-pass effect, fast onset, and a relatively high bioavailability with some drugs...

the gut. It has a total bioavailability of 10% due to an extensive first-pass effect, or up to 40% if taken after a fatty meal. Highest blood plasma levels...

dose. ADME Partition coefficient Bioavailability Drug metabolism First pass effect Polar surface area IVIVC Mehta M (2016). Biopharmaceutics Classification...

gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to...

method of treatment, as vascular delivery suffers from a "pulmonary first pass effect" where intravenous injected cells are sequestered in the lungs. Further...

tranquillisers Ethanol (alcohol) Diazoxide Drugs subject to a strong first-pass effect such as beta blockers may increase the bioavailability of hydralazine...

intake slows down absorption, but does not decrease it. Due to its first-pass effect, bioavailability is lower: about 24–30% according to different sources...

administration (first pass effect is avoided and therefore no amount drug is lost). A drug must be lipophilic (lipid soluble) in order to pass through biological...

established. Idebenone is well absorbed from the gut but undergoes excessive first pass metabolism in the liver, so that less than 1% reach the circulation. This...

the liver before reaching general circulation. This is known as the first pass effect. As a consequence, certain drugs can only be taken via certain routes...

producing complete abortion in a period of 24 hours due to the liver's first-pass effect which reduces the bioavailability of the misoprostol. Vaginal and...

first-pass effect. Less than 20% is eliminated by renal excretion. Ethylenediamine-derived antihistamines are the oldest of the five classes of first-generation...

than 40% of the oral dose, on average, is removed by the hepatic first-pass effect. Clearance of olanzapine appears to vary by sex; women have roughly...

the distal one-third of the rectum at least partially avoid the "first pass effect" through the liver, which allows for greater bio-availability of many...

mucosa bypass gastrointestinal enzymatic degradation and hepatic first-pass effect", prescribing buccal tablets is increasingly common among healthcare...

depot effect when administered by intramuscular or subcutaneous injection. Because CICs are administered parenterally, they bypass the first-pass effect in...

Dunning–Kruger effect is a cognitive bias in which people with limited competence in a particular domain overestimate their abilities. It was first described...

the gut, independently of food intake. It undergoes no measurable first-pass effect in the liver. Highest blood plasma concentrations are reached after...

absorbed after oral administration and is subject to a pronounced first-pass effect. The conversion of tilidine into the more active metabolite nortilidine...

sound effect, which had originally been recorded for the film Indiana Jones and the Temple of Doom (1984), to the Wilhelm scream sound effect. He was...

prodrug that is hydrolysed to linsidomine (SIN-1) in the liver via first-pass effect, which subsequently releases NO. 44–59% of molsidomine reach the bloodstream...

after oral administration a more pronounced metabolic clearance (high first pass effect) is responsible for a low bioavailability. The elimination after inhalation...

practically completely absorbed from the gut and undergoes no relevant first-pass effect. Highest blood plasma concentrations are reached after one hour. When...

Exemestane is quickly absorbed from the gut, but undergoes a strong first-pass effect in the liver. Highest blood plasma concentrations are reached after...

The Doppler effect (also Doppler shift) is the change in the frequency of a wave in relation to an observer who is moving relative to the source of the...