Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the Gsk3b gene...
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Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino...
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activities mediated via glycogen synthase kinase-3 beta (GSK3β) inhibition" (PDF). Trop Biomed. 39 (3): 384–393. doi:10.47665/tb.39.3.008. PMID 36214435.{{cite...
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"Inhibition of glycogen synthase kinase-3-beta (GSK3β) blocks nucleocapsid phosphorylation and SARS-CoV-2 replication". Molecular Biomedicine. 3 (1): 43. doi:10...
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may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway....
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androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells". The Journal of Biological Chemistry. 279...
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protein kinase PK40erk, cdk5/p20, CDK5/p23, glycogen synthase kinase-3beta, GSK, protein tau kinase, STK31, tau kinase, [tau-protein] kinase, tau-protein...
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the mitochondria. The Akt and ERK pathways converge to alter glycogen synthase kinase-3 beta (GSK-3β) activity. Specifically, Akt and ERK phosphorylate...
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known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism...
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MTORC1 (section Receptor tyrosine kinases)
also activates mTORC1. Activation of the Wnt pathway inhibits glycogen synthase kinase 3 beta (GSK3B). When the Wnt pathway is not active, GSK3B is able...
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Protein phosphatase 1 (category EC 3.1.3)
active form and glycogen synthase in its inactive form. Separately from inhibition of PP1, glucagon will also keep phosphorylase kinase active via cAMP...
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2/3 and activating phosphorylation of glycogen phosphorylase, and it inhibits glycogen synthesis through...
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Tolnay M, Juang YT, Tsokos GC (2002). "Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator...
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stimulation of PKA inactivates the glycolytic enzyme pyruvate kinase, inactivates glycogen synthase, and activates hormone-sensitive lipase, which catabolizes...
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Insulin receptor (category Tyrosine kinase receptors)
protein kinase, PKB (Akt), via phosphorylation. PKB then phosphorylates several target proteins, including glycogen synthase kinase 3 (GSK-3). GSK-3 is responsible...
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myocyte shape. This interaction appears to be regulated by glycogen synthase kinase 3 beta. Mutations in emerin cause X-linked recessive Emery–Dreifuss...
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activates glycogen phosphorylase kinase. Glycogen phosphorylase kinase activates glycogen phosphorylase in the same manner mentioned previously. Glycogen phosphorylase...
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3' UTR of CRACDL is predicted to be a targeted by miRNA-132, which is depicted in the conceptual translation figure. Glycogen Synthase Kinase 3 Beta (GSK3B)...
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polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. The AXIN proteins...
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enzymes including pyruvate kinase, NADP+-dependent malate dehydrogenase, citrate lyase, acetyl CoA carboxylase, fatty acid synthase, as well as pyruvate dehydrogenase...
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Glycolysis (section Pyruvate kinase)
mutations (glycogen storage diseases and other inborn errors of carbohydrate metabolism) are seen with one notable example being pyruvate kinase deficiency...
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AKT1 (category Protein kinases)
"Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase". Proc. Natl. Acad...
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a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A." J. Biol. Chem. 281 (46): 35021–9...
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been shown to increase neurite outgrowth by regulating the glycogen synthase kinase-3 beta. Progranulin may function as an autocrine growth factor in...
32 KB (3,334 words) - 03:20, 29 November 2023
phosphatidylinositol-3-kinase (PI3K). PI3K activation leads to inhibitory phosphorylation of the tau kinase glycogen synthase kinase 3 beta (GSK3B), which alters...
27 KB (3,439 words) - 10:00, 27 March 2024
Cytosolic substrates of p90rsk include protein phosphatase 1; glycogen synthase kinase 3 (GSK3); L1 CAM, a neural cell adhesion molecule; Son of Sevenless...
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propionyl Coenzyme A carboxylase, beta polypeptide PDCD10: programmed cell death 10 PIK3CA: phosphoinositide-3-kinase, catalytic, alpha polypeptide PISRT1:...
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then glycogen synthase (GYS) can bind to the growing glycogen chain and add UDP-glucose to lengthen the glucogen chain. Branches are made by glycogen branching...
59 KB (2,817 words) - 14:23, 9 June 2025
plasma membrane. Glycogen synthase kinase 3 (GSK-3) could be inhibited upon phosphorylation by Akt, which results in increase of glycogen synthesis. GSK3...
35 KB (3,831 words) - 20:54, 25 May 2025