• Thumbnail for Glycogen synthase kinase-3 beta
    Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the Gsk3b gene...
    17 KB (1,819 words) - 16:52, 22 May 2024
  • Thumbnail for GSK-3
    Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino...
    50 KB (5,806 words) - 05:47, 25 May 2025
  • Thumbnail for Andrographolide
    activities mediated via glycogen synthase kinase-3 beta (GSK3β) inhibition" (PDF). Trop Biomed. 39 (3): 384–393. doi:10.47665/tb.39.3.008. PMID 36214435.{{cite...
    9 KB (799 words) - 11:50, 18 June 2025
  • Thumbnail for Yossef Av-Gay
    "Inhibition of glycogen synthase kinase-3-beta (GSK3β) blocks nucleocapsid phosphorylation and SARS-CoV-2 replication". Molecular Biomedicine. 3 (1): 43. doi:10...
    9 KB (948 words) - 10:51, 28 June 2025
  • Thumbnail for ILKAP
    may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway....
    3 KB (448 words) - 21:07, 3 March 2023
  • Thumbnail for Androgen receptor
    androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells". The Journal of Biological Chemistry. 279...
    88 KB (9,476 words) - 01:37, 24 June 2025
  • Thumbnail for Tau-protein kinase
    protein kinase PK40erk, cdk5/p20, CDK5/p23, glycogen synthase kinase-3beta, GSK, protein tau kinase, STK31, tau kinase, [tau-protein] kinase, tau-protein...
    4 KB (404 words) - 15:58, 26 August 2023
  • Thumbnail for Lipid emulsion
    the mitochondria. The Akt and ERK pathways converge to alter glycogen synthase kinase-3 beta (GSK-3β) activity. Specifically, Akt and ERK phosphorylate...
    12 KB (1,502 words) - 17:45, 10 June 2024
  • Thumbnail for Protein kinase A
    known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism...
    27 KB (2,665 words) - 16:53, 12 May 2025
  • Thumbnail for MTORC1
    also activates mTORC1. Activation of the Wnt pathway inhibits glycogen synthase kinase 3 beta (GSK3B). When the Wnt pathway is not active, GSK3B is able...
    69 KB (7,807 words) - 19:19, 19 September 2024
  • Thumbnail for Protein phosphatase 1
    Protein phosphatase 1 (category EC 3.1.3)
    active form and glycogen synthase in its inactive form. Separately from inhibition of PP1, glucagon will also keep phosphorylase kinase active via cAMP...
    18 KB (2,050 words) - 09:57, 6 February 2025
  • Thumbnail for AMP-activated protein kinase
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2/3 and activating phosphorylation of glycogen phosphorylase, and it inhibits glycogen synthesis through...
    65 KB (7,149 words) - 16:38, 9 June 2025
  • Thumbnail for HNRPD
    Tolnay M, Juang YT, Tsokos GC (2002). "Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator...
    12 KB (1,481 words) - 18:49, 28 May 2025
  • Thumbnail for Glucagon
    stimulation of PKA inactivates the glycolytic enzyme pyruvate kinase, inactivates glycogen synthase, and activates hormone-sensitive lipase, which catabolizes...
    26 KB (2,996 words) - 00:50, 2 May 2025
  • Thumbnail for Insulin receptor
    Insulin receptor (category Tyrosine kinase receptors)
    protein kinase, PKB (Akt), via phosphorylation. PKB then phosphorylates several target proteins, including glycogen synthase kinase 3 (GSK-3). GSK-3 is responsible...
    32 KB (3,920 words) - 18:44, 1 May 2025
  • Thumbnail for Emerin
    myocyte shape. This interaction appears to be regulated by glycogen synthase kinase 3 beta. Mutations in emerin cause X-linked recessive Emery–Dreifuss...
    20 KB (2,339 words) - 15:45, 23 May 2025
  • Thumbnail for Glycogen phosphorylase
    activates glycogen phosphorylase kinase. Glycogen phosphorylase kinase activates glycogen phosphorylase in the same manner mentioned previously. Glycogen phosphorylase...
    26 KB (2,918 words) - 07:33, 25 May 2025
  • Thumbnail for CRACD-like protein
    3' UTR of CRACDL is predicted to be a targeted by miRNA-132, which is depicted in the conceptual translation figure. Glycogen Synthase Kinase 3 Beta (GSK3B)...
    15 KB (1,339 words) - 13:33, 11 May 2025
  • Thumbnail for AXIN2
    polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. The AXIN proteins...
    11 KB (1,422 words) - 12:33, 24 December 2023
  • enzymes including pyruvate kinase, NADP+-dependent malate dehydrogenase, citrate lyase, acetyl CoA carboxylase, fatty acid synthase, as well as pyruvate dehydrogenase...
    18 KB (1,917 words) - 15:54, 9 January 2025
  • Thumbnail for Glycolysis
    mutations (glycogen storage diseases and other inborn errors of carbohydrate metabolism) are seen with one notable example being pyruvate kinase deficiency...
    82 KB (8,731 words) - 04:57, 2 June 2025
  • Thumbnail for AKT1
    AKT1 (category Protein kinases)
    "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase". Proc. Natl. Acad...
    24 KB (2,818 words) - 09:21, 25 January 2025
  • Thumbnail for FRAT1
    a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A." J. Biol. Chem. 281 (46): 35021–9...
    5 KB (653 words) - 01:31, 30 December 2023
  • Thumbnail for Granulin
    been shown to increase neurite outgrowth by regulating the glycogen synthase kinase-3 beta. Progranulin may function as an autocrine growth factor in...
    32 KB (3,334 words) - 03:20, 29 November 2023
  • Thumbnail for Low-density lipoprotein receptor-related protein 8
    phosphatidylinositol-3-kinase (PI3K). PI3K activation leads to inhibitory phosphorylation of the tau kinase glycogen synthase kinase 3 beta (GSK3B), which alters...
    27 KB (3,439 words) - 10:00, 27 March 2024
  • Thumbnail for Ribosomal s6 kinase
    Cytosolic substrates of p90rsk include protein phosphatase 1; glycogen synthase kinase 3 (GSK3); L1 CAM, a neural cell adhesion molecule; Son of Sevenless...
    5 KB (510 words) - 04:00, 14 April 2025
  • Thumbnail for AKT2
    AKT2 (redirect from RAC-BETA)
    "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase". Proceedings of...
    13 KB (1,538 words) - 09:28, 24 April 2025
  • Thumbnail for Chromosome 3
    propionyl Coenzyme A carboxylase, beta polypeptide PDCD10: programmed cell death 10 PIK3CA: phosphoinositide-3-kinase, catalytic, alpha polypeptide PISRT1:...
    34 KB (1,991 words) - 14:29, 20 April 2025
  • Thumbnail for Inborn errors of carbohydrate metabolism
    then glycogen synthase (GYS) can bind to the growing glycogen chain and add UDP-glucose to lengthen the glucogen chain. Branches are made by glycogen branching...
    59 KB (2,817 words) - 14:23, 9 June 2025
  • Thumbnail for Protein kinase B
    plasma membrane. Glycogen synthase kinase 3 (GSK-3) could be inhibited upon phosphorylation by Akt, which results in increase of glycogen synthesis. GSK3...
    35 KB (3,831 words) - 20:54, 25 May 2025