Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate...

Nucleoside-diphosphate kinase Guanine nucleotide exchange factor Buday, L; Downward J (1993). "Epidermal growth factor regulates p21ras through the formation...

allows it to act as a guanine nucleotide exchange factor (GEF). The GPCR can then activate an associated G protein by exchanging the GDP bound to the G...

molecular biology, the EF1 guanine nucleotide exchange domain is a protein domain found in the beta and delta chains of elongation factors from eukaryotes and...

(about 45-60 nucleotides per second).[citation needed] In eukaryotes the rate is about two amino acids per second (about 6 nucleotides read per second)...

G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in...

Hansen SH, Casanova JE (1998). "ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6". J. Biol. Chem. 273 (1): 23–7. doi:10.1074/jbc...

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene. ARHGEF6 is commonly known as the p21-activated protein...

similar to eukaryotic EF-1B. EF-Ts serves as the guanine nucleotide exchange factor for EF-Tu (elongation factor thermo unstable), catalyzing the release of...

Guanine nucleotide Exchange Factor) is a 97 kDa protein involved in intracellular signalling networks. It functions as a guanine nucleotide exchange factor...

membrane-associated G-protein known as Ras. The guanine nucleotide exchange factor mediates Ras activation through the GDP-GTP exchange process. The active Ras protein...

guanine nucleotide exchange factor 3 also known as exchange factor directly activated by cAMP 1 (EPAC1) or cAMP-regulated guanine nucleotide exchange...

Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene. This protein is also called RhoGEF11 or PDZ-RhoGEF...

Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4), also known as exchange protein directly activated by cAMP 2 (EPAC2) is a protein that in humans...

complex. Finally, with the help of the guanine nucleotide exchange factor (GEF) eIF2B, the GDP in eIF2 is exchanged for a GTP and the ternary complex reforms...

hormone or neurotransmitter), the activated receptor acts as a guanine nucleotide exchange factor to promote GDP release from and guanosine triphosphate (GTP)...

Leukemia-associated Rho guanine nucleotide exchange factor (LARG). Rho guanine nucleotide exchange factor 12 is guanine nucleotide exchange factor (GEF) for the...

Gautel M (July 2001). "Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly". The Journal of Cell...

and PLEKHG2 having this domain also acts as a Rho-specific guanine nucleotide exchange factor (RhoGEF). Activation of RhoGTPase reconstitute the actin cytoskeleton...

link cell surface G protein-coupled receptors primarily to guanine nucleotide exchange factors for the Rho small GTPases to regulate the actin cytoskeleton...

proteins (GAPs) force ARF to hydrolyze bound GTP to GDP, and Guanine nucleotide exchange factors force ARF to adopt a new GTP molecule in place of a bound...

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene. This protein is also called RhoGEF1 or p115-RhoGEF...

Son of Sevenless (SOS) refers to a set of genes encoding guanine nucleotide exchange factors that act on the Ras subfamily of small GTPases. The gene...

a GPCR, the GPCR acquires GEF (guanine nucleotide exchange factor) ability, which activates the G-protein by exchanging the GDP on the alpha subunit to...

bind to a nuclear transport factor, where a Guanine Nucleotide Exchange Factor Protein can come to catalyze the exchange of GTP for GDP. We also see GTP...

ARHGEF11, and ARHGEF12. These ARHGEF proteins function as guanine nucleotide exchange factors for the Rho small GTPases to regulate the actin cytoskeleton...

states via the exchange of GDP to GTP (conducted simultaneously via guanine nucleotide exchange factors and GTPase activating factor). RhoA is activated...

factor (ARF) is a GTPase involved in membrane traffic. There are 6 mammalian ARFs which are regulated by over 30 guanine nucleotide exchange factors (GEFs)...

company Graphical Editing Framework, a software framework Guanine nucleotide exchange factor, a group of proteins Greek Expeditionary Force (Korea), during...

ARHGEF10L Rho guanine nucleotide exchange factor 10L ARHGEF11 Rho guanine nucleotide exchange factor 11 ARHGEF40 Rho guanine nucleotide exchange factor 40 ARHGEF7...