protein Msh2 also known as MutS homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. MSH2 is a tumor...

helicase, single-stranded-DNA binding-protein (RPA), and DNA polymerases. MSH2 protein dimerizes with MSH6 protein, which identifies mismatches via a sliding...

such as keratoacanthomas and sebaceous tumors. The genes affected are MLH1, MSH2, and more recently, MSH6, and are involved in DNA mismatch repair. Muir–Torre...

mismatch repair (MMR) system. MSH3 typically forms the heterodimer MutSβ with MSH2 in order to correct long insertion/deletion loops and base-base mispairs...

genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–08. doi:10.1093/carcin/bgl079...

13%-100% for the DNA repair genes BRCA1, WRN, FANCB, FANCF, MGMT, MLH1, MSH2, MSH4, ERCC1, XPF, NEIL1 and ATM. These epigenetic defects occurred in various...

– particularly early-onset prostate cancer – including BRCA1, ATM, NBS1, MSH2, MSH6, PMS2, CHEK2, RAD51D, and PALB2. Additionally, variants in the genome...

site. In eukaryotes, MutS homologs form two major heterodimers: Msh2/Msh6 (MutSα) and Msh2/Msh3 (MutSβ). The MutSα pathway is involved primarily in base...

identified in the budding yeast S. cerevisiae because of its homology to MSH2. The identification of the human GTBP gene and subsequent amino acid sequence...

proteins. The seven DNA mismatch repair proteins in humans are MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2. In addition, there are Exo1-dependent and Exo1-independent...

similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in DNA mismatch repair and homologous recombination...

with H2O2 for 30 minutes causes the mismatch repair protein heterodimer MSH2-MSH6 to recruit DNA methyltransferase 1 (DNMT1) to sites of some kinds of...

Carvalho L (2014). "Promoter hypermethylation of DNA repair genes MLH1 and MSH2 in adenocarcinomas and squamous cell carcinomas of the lung". Revista Portuguesa...

genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079...

the gene that increases the risk for a common type of colon cancer. The MSH2 gene and later the MLH1 gene (also by DFCI investigators) are linked to hereditary...

coli) 1:3500 APC Lynch syndrome 5–10% of all cases of bowel cancer MLH1, MSH2, MSH6, PMS2 Fanconi anemia 1:130000 births FANCC Neurological conditions...

Lynch syndrome is caused by mutations in mismatch repair genes, including MSH2, MLH1, MLH6, PMS1, and PMS2. The risk of ovarian cancer for an individual...

applications included the detection of exon deletions in the human genes BRCA1, MSH2 and MLH1, which are linked to hereditary breast and colon cancer. Now MLPA...

potential cancer driver. Studies in mice indicate it drives transformation of MSH2-deficient colon epithelial cells. Owing to the importance of butyrate as...

Park CS, Juhng SW, Lee JH (2011). "Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma-carcinoma sequence"...

constitutional mismatch repair-deficiency (CMMR-D), it has been mapped to MLH1, MSH2, MSH6 or PMS2. Monoallelic mutations of these genes are observed in the condition...

HGNC:56248 A0A1W2PQ72 9905 MSC HGNC:7321 O60682 9906 MSGN1 HGNC:14907 A6NI15 9907 MSH2 HGNC:7325 P43246 9908 MSH3 HGNC:7326 P20585 9909 MSH4 HGNC:7327 O15457 9910...

genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–2408. doi:10.1093/carcin/bgl079...

pituitary gland, and related to skin pigmentation DNA mismatch repair genes: MSH2 MSH3 MSH4 MSH5 MSH6 Multiple system atrophy Mycothiol, an unusual thiol that...

and activation of oncogenes. (e.g., p53 and DNA mismatch repair protein 2 (MSH2)). Certain genes can also act as tumor suppressors and oncogenes. Dubbed...

recombination occur. CHEK2 has been shown to interact with: BRCA1 GINS2 MDC1 MSH2 MUS81 PLK1 PLK3 GRCh38: Ensembl release 89: ENSG00000183765 – Ensembl, May...

with H2O2 for 30 minutes causes the mismatch repair protein heterodimer MSH2-MSH6 to recruit DNA methyltransferase 1 (DNMT1) to sites of some kinds of...

localization soon led them and other groups to identify repair genes such as MSH2 and MLH1 that are responsible for most cases of this syndrome. In the early...

Lynch syndrome is caused by mutations in DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2; see main article Hereditary nonpolyposis colorectal cancer...

Dystrophy Multiple dominant or recessive 1:14,500-123,000 Lynch syndrome MSH2, MLH1, MSH6, PMS2, PMS1, TGFBR2, MLH3 1:279 lipoprotein lipase deficiency...