• The mitochondrial permeability transition pore (mPTP or MPTP; also referred to as PTP, mTP, or MTP) is a protein pore complex that forms in the inner...
    32 KB (3,472 words) - 23:00, 17 June 2025
  • Thumbnail for Antamanide
    shown that the compound inhibits mitochondrial permeability transition pore (MPTP) by inhibiting the activity of the pore regulator, cyclophilin D (CyP-D)...
    6 KB (696 words) - 13:05, 10 November 2024
  • Thumbnail for Ciclosporin
    change of permeability is considered a cellular catastrophe, leading to cell death. However, brief mitochondrial permeability transition pore openings...
    58 KB (5,376 words) - 15:25, 1 June 2025
  • Thumbnail for Mitochondrion
    hostile conditions. Anti-mitochondrial antibodies Mitochondrial metabolic rates Mitochondrial permeability transition pore Mitophagy Nebenkern Oncocyte...
    172 KB (18,906 words) - 16:53, 20 June 2025
  • Thumbnail for Cyclophilin
    structural component of the mitochondrial permeability transition pore. The pore opening raises the permeability of the mitochondrial inner membrane, allows...
    8 KB (883 words) - 03:16, 19 August 2024
  • protein, a liver protein linked to LDL release Mitochondrial permeability transition pore Mitochondrial trifunctional protein, a protein which catalyzes...
    3 KB (448 words) - 11:47, 18 June 2025
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    an ischemic event is termed “reperfusion injury”. The mitochondrial permeability transition pore (mPTP) is normally closed during ischemia, but calcium...
    12 KB (1,502 words) - 17:45, 10 June 2024
  • Thumbnail for ATP synthase subunit C
    c-subunit has been indicated as a critical component of the mitochondrial permeability transition pore. ATPase, Vo complex, proteolipid subunit C, InterPro: IPR000245...
    6 KB (797 words) - 20:13, 18 March 2025
  • Thumbnail for Mitochondrial membrane transport protein
    the tissues. Examples of mitochondrial transport proteins include the following: The mitochondrial permeability transition pore, which opens in response...
    30 KB (3,434 words) - 03:54, 2 December 2024
  • Thumbnail for PPIF
    mitochondrial permeability transition pore (MPTP) and, thus, highly involved in mitochondrial metabolism and apoptosis, as well as in mitochondrial diseases...
    13 KB (1,594 words) - 21:14, 9 April 2024
  • Thumbnail for Reperfusion injury
    so-called mitochondrial permeability transition pore (MPT pore) in the mitochondrial membrane of cardiac cells. The opening of the MPT pore leads to the...
    31 KB (3,212 words) - 17:50, 10 June 2025
  • Thumbnail for Voltage-dependent anion channel
    pore to release of apoptogenic factors such as cytochrome c. However, VDAC are not essential components of the mitochondrial permeability transition pore...
    15 KB (1,716 words) - 14:00, 9 June 2025
  • Thumbnail for Necroptosis
    the mitochondrial electron transport chain leads to additional mitochondrial damage and opening of the mitochondrial permeability transition pore, which...
    14 KB (1,667 words) - 09:21, 5 November 2024
  • Thumbnail for Adenine nucleotide translocator
    important modulatory and possible structural component of the Mitochondrial Permeability Transition Pore, a channel involved in various pathologies whose function...
    25 KB (2,730 words) - 14:51, 11 June 2025
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    Y (December 1998). "Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria"...
    34 KB (4,089 words) - 18:52, 28 May 2025
  • Thumbnail for Apoptosome
    The first involves the mitochondrial permeability transition pore (mPTP), which opens in response to elevated mitochondrial Ca2+ levels and oxidative...
    36 KB (4,346 words) - 05:11, 13 June 2025
  • Thumbnail for Phosphate carrier protein, mitochondrial
    involved in regulation of the mitochondrial permeability transition pore (mPTP). Mutations in this gene can cause mitochondrial phosphate carrier deficiency...
    13 KB (1,581 words) - 18:57, 8 April 2024
  • oxidative stress, p53 accumulates in the mitochondrial matrix and triggers mitochondrial permeability transition pore (PTP) opening. To the end of this, necrosis...
    12 KB (1,486 words) - 23:23, 4 October 2023
  • Thumbnail for Excitotoxicity
    excess calcium in the cytosol is the opening of the mitochondrial permeability transition pore, a pore in the membranes of mitochondria that opens when the...
    25 KB (2,853 words) - 18:04, 18 June 2025
  • Thumbnail for Conditions comorbid to autism
    intermediates, and regulate cell death through activation of the mitochondrial permeability transition pore (mtPTP). When they fail, less and less energy is generated...
    79 KB (8,674 words) - 10:08, 13 June 2025
  • Thumbnail for Bongkrek acid
    internal membrane channel of the mitochondrial permeability transition pore, known as MPTP. Bongkrek acid is permeable through this membrane and binds...
    16 KB (1,679 words) - 16:47, 18 April 2025
  • into mitochondria, which can prevent the opening of the mitochondrial permeability transition pore, it has been investigated as a therapeutic treatment for...
    4 KB (328 words) - 15:33, 20 June 2022
  • Thumbnail for Apoptosis regulator BAX
    suggests that activated BAX and/or Bak form an oligomeric pore, MAC in the MOM (mitochondrial outer membrane). This results in the release of cytochrome...
    18 KB (2,092 words) - 13:58, 29 November 2024
  • response can be exploited for detecting the opening of the mitochondrial permeability transition pore (mPTP) and for measuring cell volume changes. Calcein...
    8 KB (626 words) - 06:34, 9 June 2025
  • Mitochondrial outer membrane permeabilization (MOMP), also known as the mitochondrial outer membrane permeability, is one of two ways apoptosis (a type...
    4 KB (478 words) - 23:32, 24 April 2025
  • ATP-sensitive potassium channel, the mitochondrial ATP-sensitive potassium channel, the mitochondrial permeability transition pore, reactive oxygen species generation...
    10 KB (1,235 words) - 05:41, 26 May 2025
  • Thumbnail for Mitochondrial fusion
    coupled with outer mitochondrial membrane destabilization that is opportunistically employed during the mitochondrial permeability transition. Mutations in...
    21 KB (2,552 words) - 21:33, 5 June 2025
  • with the mitochondrial permeability transition pore (MPTP), a non-selective, high conductance channel spanning the inner and outer mitochondrial membrane...
    23 KB (2,645 words) - 23:33, 27 May 2025
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    genetic control of necrosis-like cell death through the mitochondrial permeability transition pore". Molecular and Cellular Biology. 20 (15): 5454–68. doi:10...
    21 KB (2,693 words) - 19:41, 18 March 2025
  • may refer to: Peak-to-peak, an amplitude of a signal Permeability transition pore, a mitochondrial channel protein complex Post-tetanic potentiation, a...
    2 KB (248 words) - 06:34, 25 November 2024