N6-Methyladenosine (m6A) was originally identified and partially characterised in the 1970s, and is an abundant modification in mRNA and DNA. It is found...

The most common and well-understood mRNA modification at present is N6-Methyladenosine (m6A), which has been observed to occur an average of three times...

before DNA methylation in the early forms of life evolving on earth. N6-methyladenosine (m6A) is the most common and abundant methylation modification in...

In enzymology, a mRNA (2'-O-methyladenosine-N6-)-methyltransferase (EC 2.1.1.62) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine...

identify m5C modifications on mRNA instead of the original target N6-methyladenosine. The easy switch between different modifications as target is made...

subsequently discovered the first RNA demethylase that oxidatively reverses N6-methyladenosine (m6A) methylation in mammalian messenger RNA (mRNA) in 2011. The existence...

methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine (m6A). METTL3 forms the m6 a methyltransferase complex with METTL14...

Nagaraja; Wu, Li (March 2019). "HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication". Journal...

YTH N6-methyladenosine RNA binding protein 2 is a protein that in humans is encoded by the YTHDF2 gene. This gene encodes a member of the YTH (YT521-B...

even cytoplasmic (structural) heritable states. RNA methylation of N6-methyladenosine (m6A) as the most abundant eukaryotic RNA modification has recently...

gene. It is an RNA-binding protein that acts as a key regulator of N6-Methyladenosine (m6A) methylation of RNAs GRCh38: Ensembl release 89: ENSG00000162775...

3-methyluridine in single-stranded RNA, with low efficiency. The nucleoside N6-methyladenosine (m6A), an abundant modification in RNA, was then found to be a major...

5′(m7Gp)(ppAm)[pN]n), it can be further methylated at the N6 methyl position to form N6-methyladenosine, resulting in 5′(m7Gp)(ppm6Am)[pN]n. The mechanism of...

generated, including those for PTB, RbFox2, SFRS1, hnRNP C, and even N6-Methyladenosine (m6A) mRNA modifications. HITS-CLIP of the RNA-binding protein Argonaute...

Guerrero, P Xie, E He, B Shen#, C He#. YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs. elife 2017,6, e31311 H Shi*, X Wang*, Z Lu, B S...

protein, an enzyme responsible for removing the methylation from N6-methyladenosine in nucleic acids. The pharmacokinetics of rhein have not been intensively...

seven major classes of chemical modifications found in RNA molecules: N6-methyladenosine, 2'-O-methylation, N6,2'-O-dimethyladenosine, 5-methylcytidine,...

Eukaryotic mRNA contains chemically modified nucleotides such as N6-methyladenosine, 5-methylcytidine, and 2'-O-methylated nucleotides. Although only...

humans, is the first identified RNA demethylase. It demethylates N6-methyladenosine in mRNA. There is also another very different protein called AlkB...

splicing. More recently, SNORD90 has been suggested to be able to guide N6-methyladenosine (m6A) modifications onto target RNA transcripts. More specifically...

hosted on the UCSC Genome Browser MethDB DNA Methylation database N6-Methyladenosine Protein methylation D. B. Dunn, J. D. Smith: "The occurrence of 6-methylaminopurine...

when compared to control hepatocytes. In a 2015 study on the role of N6-methyladenosine (m6A) demethylation on adipogenesis, researchers treated porcine adipocytes...

member 1 is a protein that in humans is encoded by the YTHDF1 gene. N6-Methyladenosine GRCh38: Ensembl release 89: ENSG00000149658 – Ensembl, May 2017 GRCm38:...

RNA binding. The YTH domain proteins also serve as readers for the N6-methyladenosine (m6A) mRNA modification by scanning the mRNA to find the modified...

vacuolar protein sorting 37 homolog A WRN: Werner syndrome YTHDF3: YTH N6-methyladenosine RNA binding protein 3 ZFP41: encoding protein ZFP41 zinc finger protein...

demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation". J. Biol. Chem. 289 (25): 17299–311. doi:10.1074/jbc...

Gene ontology Molecular function N6-methyladenosine-containing RNA binding pre-mRNA intronic binding miRNA binding single-stranded telomeric DNA binding...

and that the RNA is found to be post-translationally modified by N6-methyladenosine (m6A) on its 5' ends or RNA acetylation ac4C. Recent work has shown...

Zhao, Mingmin (October 2022). "AlkB RNA demethylase homologues and N6 -methyladenosine are involved in Potyvirus infection". Molecular Plant Pathology....

Pseudo-seq, Ψ-seq, CeU-seq, Aza-IP, RiboMeth-seq). It contains ~124200 N6-Methyladenosines (m6A), ~9500 pseudouridine (Ψ) modifications, ~1000 5-methylcytosine...