field of molecular biology, the peroxisome proliferator–activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription...
18 KB (1,885 words) - 06:27, 15 April 2025
proliferator-activated receptor delta and peroxisome proliferator-activated receptor gamma, PPAR-alpha is part of the subfamily of peroxisome proliferator-activated receptors...
22 KB (2,602 words) - 18:54, 1 May 2025
Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone reverse insulin resistance receptor, or NR1C3 (nuclear...
19 KB (2,091 words) - 16:26, 26 May 2025
Peroxisome proliferator-activated receptor delta (PPAR-delta), or (PPAR-beta), also known as Nuclear hormone receptor 1 (NUC1) is a nuclear receptor that...
18 KB (1,963 words) - 10:40, 5 February 2025
PPAR agonist (redirect from Peroxisome proliferator-activated receptor agonist)
PPAR agonists are drugs which act upon the peroxisome proliferator-activated receptor. They are used for the treatment of symptoms of the metabolic syndrome...
10 KB (1,227 words) - 21:57, 29 May 2025
expression of GLUT1 and SLC1A5. Acadesine GFT505 GW0742 Irisin Peroxisome proliferator-activated receptor Sodelglitazar SR9009 Koh B (2013-03-22). "Anti-doping...
21 KB (2,027 words) - 03:42, 10 May 2025
Telmisartan (category Angiotensin II receptor antagonists)
from PPAR-γ. Telmisartan's activity at the peroxisome proliferator-activated receptor delta (PPAR-δ) receptor has prompted speculation around its potential...
19 KB (1,699 words) - 20:43, 1 April 2025
used as the lysine dihydrate salt. It is a peroxisome proliferator-activated receptor delta (PPARδ) receptor agonist. The compound was licensed from Janssen...
9 KB (563 words) - 22:08, 29 May 2025
proposed to be the peroxisome proliferator-activated receptor alpha (PPAR-α). PEA also has affinity to cannabinoid-like G-coupled receptors GPR55 and GPR119...
47 KB (5,040 words) - 12:26, 11 January 2025
metabolite GFT1007 are peroxisome proliferator-activated receptor (PPAR) agonists, both of which activate PPAR-alpha, PPAR-gamma, and PPAR-delta in vitro. In June...
15 KB (984 words) - 20:41, 29 May 2025
Thiazolidinediones or TZDs act by activating PPARs (peroxisome proliferator-activated receptors), a group of nuclear receptors, specific for PPARγ (PPAR-gamma...
20 KB (2,167 words) - 13:56, 24 May 2025
Roberts-Thomson SJ (July 2004). "Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons"...
9 KB (827 words) - 19:19, 6 May 2024
increased risk of rhabdomyolysis. Fibrates stimulate peroxisome proliferator activated receptor (PPAR) alpha, which controls the expression of gene products...
10 KB (1,091 words) - 01:14, 8 October 2024
German assessment notes that a 2005 study found PFOA to be genotoxic via a peroxisome proliferation pathway that produced oxygen radicals in HepG2 cells, and...
125 KB (13,081 words) - 01:14, 25 May 2025
cord injury. Another unusual activity is inhibition of the sweet taste receptor. After oral administration, peak serum concentration is reached after 1–2 hours...
67 KB (6,232 words) - 21:08, 29 May 2025
"15-deoxy-delta12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-gamma, induces neuronal apoptosis". NeuroReport. 12 (4):...
23 KB (3,054 words) - 23:44, 29 November 2024
agonist at the subtypes α (alpha) and γ (gamma) of the peroxisome proliferator-activated receptor (PPAR). Agonist action on PPARα lowers high blood triglycerides...
9 KB (767 words) - 21:52, 3 March 2025
Another potential target of antiepileptic drugs is the peroxisome proliferator-activated receptor alpha. Some anticonvulsants have shown antiepileptogenic...
71 KB (5,805 words) - 19:59, 29 May 2025
lipolysis. It does so by activating peroxisome proliferator-activated receptor alpha (PPARα) 'transcription factor ligand', a receptor that is involved in...
12 KB (927 words) - 02:17, 2 December 2024
Berberine (category M2 receptor agonists)
WY-14643 Antagonists: GW-6471 MK-886 PPARδTooltip Peroxisome proliferator-activated receptor delta Agonists: 15-HETE 15-HpETE Arachidonic acid Bezafibrate...
14 KB (1,166 words) - 03:10, 4 May 2025
Pemafibrate, sold under the brand name Parmodia, is a peroxisome proliferator-activated receptor alpha (PPARα) agonist. It is developed and marketed by...
4 KB (91 words) - 06:25, 16 December 2024
ester. It lowers lipid levels by activating peroxisome proliferator-activated receptor alpha (PPARα). PPARα activates lipoprotein lipase and reduces apoprotein...
27 KB (2,560 words) - 20:50, 29 May 2025
Arachidonic acid (section PLA2 activation)
arachidonic acid. Receptors that activate this pathway include: A1 receptor D2 receptor α2 adrenergic receptor 5-HT1 receptor PLC may also be activated by MAP kinase...
21 KB (1,890 words) - 17:15, 31 May 2025
(February 1996). "The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones"...
6 KB (424 words) - 18:34, 28 May 2025
Cannabigerol (category Alpha-2 adrenergic receptor agonists)
concentration = 160 nM). It is also a weak agonist of the peroxisome proliferator-activated receptor PPAR-γ (EC50 = 1,270–15,700 nM). CBG is a voltage-gated sodium...
22 KB (1,769 words) - 20:15, 29 May 2025
Schwammenthal E, Adler Y, Goldenberg I, et al. (May 2004). "Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus...
8 KB (728 words) - 08:11, 23 January 2025
Aleglitazar is a peroxisome proliferator-activated receptor agonist (hence a PPAR modulator) with affinity to PPARα and PPARγ, which was under development...
3 KB (85 words) - 08:26, 11 September 2024
selective PPAR modulator (SPPARM) is a selective receptor modulator of the peroxisome proliferator-activated receptor (PPAR). Examples include SPPARMs of the PPARγ...
3 KB (303 words) - 11:20, 31 October 2023
of drugs and an agonist of peroxisome proliferator-activated receptor-γ (PPAR-γ), an orphan member of the nuclear receptor superfamily of transcription...
3 KB (196 words) - 11:44, 10 February 2025
Pioglitazone selectively stimulates the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) and to a lesser extent PPAR-α. It...
28 KB (2,661 words) - 21:54, 29 May 2025