domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c is a protein that in humans is encoded by the ADAM10 gene. Members of the ADAM family are...

cells and anchored in the cell membrane. Several such proteins, notably ADAM10, have been identified as possessing alpha-secretase activity. Upon cleavage...

or shed extracellular portions of transmembrane proteins. For example, ADAM10 can cut off part of the HER2 receptor, thereby activating it. ADAM genes...

demultiply[clarification needed] the yield of agonists. Sheddase inhibitors active on ADAM10 and ADAM17 can potentiate anti-cancer therapy. It has been postulated that...

ADAM10 endopeptidase (EC 3.4.24.81, Kuzbanian protein, myelin-associated disintegrin metalloproteinase) is an enzyme. This enzyme catalyses the following...

target proteins of triptolide have been reported, including polycystin-2, ADAM10, DCTPP1, TAB1, and XPB. Multiple triptolide-resistant mutations exist in...

intracellular tail of approximately 60 amino acids. Its main binding partner is the ADAM10 protein, a sheddase that interacts with a variety of adhesion molecules...

contradicted by further research. More specifically, aderbasib is an inhibitor of ADAM10 and ADAM17. "STATEMENT ON A NONPROPRIETARY NAME ADOPTED BY THE USAN COUNCIL"...

HGNC:214 Q9H2U9 251 ADAM8 HGNC:215 P78325 252 ADAM9 HGNC:216 Q13443 253 ADAM10 HGNC:188 O14672 254 ADAM11 HGNC:189 O75078 255 ADAM12 HGNC:190 O43184 256...

the sequence for human ADAM10 can be retrieved by entering ADAM10, disintegrin, AF009615 (the GenBank accession number of ADAM10), or H69859 (the GenBank...

sheddases have been implicated in the proteolytic cleavage of LRP1 such as ADAM10, ADAM12, ADAM17 and MT1-MMP. LRP1 is also continuously endocytosed from...

ectodomain of FAT1 can also be shed from the cell surface by the sheddase ADAM10, with release of this ectodomain a possible new biomarker in pancreatic...

receptor-dependent LTP. Constitutive and activity-dependent cleavage of NG2 by ADAM10 releases the ectodomain, which contains two N-terminal LNS domains that...

pappalysin-1 EC 3.4.24.80: membrane-type matrix metalloproteinase-1 EC 3.4.24.81: ADAM10 endopeptidase EC 3.4.24.82: ADAMTS-4 endopeptidase EC 3.4.24.83: anthrax...

Petros; Foster, Brian L.; Simmer, James P.; Bartlett, John D. (2024-12-07). "ADAM10 Expression by Ameloblasts Is Essential for Proper Enamel Formation". International...

in the a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) gene. This association was first shown in 2013.[citation needed] Skin lesion...

regions, or through proteolytic cleavage of mRAGE by specific enzymes such as ADAM10 or matrix metalloproteinases (MMPs). Upon ligand binding, mRAGE recruits...

also begin expressing proteases capable of degrading cadherins such as ADAM10 and secreting matrix metalloproteinases (MMPs) that degrade the overlying...

extracellular domain interacts with a ligand, an ADAM-family metalloprotease called ADAM10, cleaves the notch protein just outside the membrane. This releases the...

"HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases". Molecular Cell. 49 (4): 668–79. doi:10.1016/j.molcel.2012.12...

Margaret; Buxbaum, Joseph D. (2012-02-01). "Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer disease". Neurobiology of Aging. 33 (2):...

Dempsey P, Lenhart PM, et al. (December 2007). "The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding...

same time. Part of the ectodomain of TREM2 can be processed by enzymes (ADAM10, ADAM17) and released as a soluble version, called soluble TREM2 (sTREM2)...

breast cancer cells, Paxillin phosphorylation at S272 and S274 activates ADAM10 protease, and STAT5 phosphorylation at S779 modulates BCL-ABL-mediated leukemogenesis...

and Tie-1 undergo proteolytic cleavage of the ectodomains by ADAM17 and ADAM10. This cleavage frees the cytoplasmic fragment for cellular signaling. In...

PMC 4354543. PMID 25650626. Kwon J, Jeong SM, Choi I, Kim NH (2016). "ADAM10 Is Involved in Cell Junction Assembly in Early Porcine Embryo Development"...

Haas IG, Schulte M, Ludwig A, Frank M, Saftig P (August 2006). "Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell...

TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10". J Immunol. 172 (10): 6362–72. doi:10.4049/jimmunol.172.10.6362. PMID 15128827...

Proteolytic cleavage of the AXL extracellular domain by the metalloproteinases ADAM10 and ADAM17 can downregulate this signalling activity. Signalling pathways...

pharmaceutical and biotech companies. Other AD genes Tanzi has discovered include ADAM10, UBQLN1, IDE, A2M, ITGB3, and ATXN1. In 2019, Tanzi, his ex-trainee, Jaehong...