protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress...
42 KB (4,614 words) - 19:07, 4 August 2025
Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response...
46 KB (5,537 words) - 04:52, 15 July 2025
The AP-1 binding site, also known as the AP-1 promoter site, is a DNA sequence to which AP-1 transcription factors are able to bind. The AP-1 binding...
982 bytes (113 words) - 15:58, 19 September 2022
molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information...
75 KB (8,351 words) - 22:53, 24 June 2025
JUNB (category Transcription factors)
growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'. JUNB has been shown to interact with BRCA1, and SMAD3. AP-1 (transcription factor) GRCh38:...
9 KB (1,199 words) - 04:20, 15 July 2025
JunD (category Transcription factors)
with ATF3, MEN1, DNA damage-inducible transcript 3 and BRCA1. AP-1 (transcription factor) GRCh38: Ensembl release 89: ENSG00000130522 – Ensembl, May 2017...
13 KB (1,561 words) - 17:05, 17 July 2025
JNK is phosphorylated, which leads to the phosphorylation of AP-1 (transcription factor consisting of cFOS and Cjun). This results in the activation of...
8 KB (935 words) - 04:17, 28 May 2025
ATF1 (redirect from Activating transcription factor 1)
AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an activating transcription factor, which...
11 KB (1,380 words) - 03:53, 15 July 2025
BATF (gene) (category Transcription factors)
basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization...
7 KB (885 words) - 15:47, 17 July 2025
Lithium (medication) (section Neurotrophic factors)
mesencephalic astrocyte-derived neurotrophic factor (MANF), another neurotrophic factor, via the AP-1 transcription factor. MANF is able to regulate proteostasis...
106 KB (11,342 words) - 17:43, 6 August 2025
SV40 (redirect from Macaca mulatta polyomavirus 1)
of synthesis. This is done by binding (dimerization) with the AP-1 transcription factor to give a primary transcript that is 3' polyadenylated and 5'...
21 KB (2,522 words) - 18:30, 17 July 2025
FOSB (category Transcription factors)
of the JUN family (e.g., c-Jun, JunD), thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators...
57 KB (7,191 words) - 16:36, 17 July 2025
Psychiatry. 27 (1): 624–639. doi:10.1038/s41380-021-01256-1. PMC 8960411. PMID 34453125. Hope BT (May 1998). "Cocaine and the AP-1 transcription factor complex"...
201 KB (20,633 words) - 06:04, 25 July 2025
Activating transcription factor, ATF, is a group of bZIP transcription factors, which act as homodimers or heterodimers with a range of other bZIP factors. First...
3 KB (310 words) - 08:38, 6 November 2024
USF1 (redirect from Upstream Transcription Factor 1)
stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene. The upstream stimulatory factor (USF) gene encodes a transcription factor USF that...
41 KB (4,563 words) - 09:19, 18 July 2025
This list of manually curated human transcription factors is taken from Lambert, Jolma, Campitelli et al. It was assembled by manual curation. More detailed...
374 KB (81 words) - 11:17, 3 January 2025
BZIP domain (section bZIP transcription factors)
factors affecting reproductive functions, and several other phenomena that affect human health. AP-1 fos/jun heterodimer that forms a transcription factor...
7 KB (663 words) - 00:42, 13 March 2024
glucocorticoid hormone. This work led to the identification of AP-1 transcription factors, later found to be composed of Jun and Fos prototo- oncoproteins...
7 KB (674 words) - 13:16, 27 January 2025
The GATA transcription factor family consists of six DNA-binding proteins (GATA1-6) that regulates transcription of DNA due to their ability to bind to...
8 KB (995 words) - 06:20, 25 July 2024
FOSL2 (category Transcription factors)
dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators...
5 KB (678 words) - 06:36, 4 August 2025
ATF/CREB (category Transcription factors)
the transcription factors assigned to this group, some are more related to CREB-like, factors, whereas other exhibit closer similarity with the AP-1 transcription...
2 KB (225 words) - 20:32, 13 October 2022
Transcription factor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene. The protein encoded by this gene...
30 KB (3,441 words) - 08:44, 5 February 2025
General transcription factors (GTFs), also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific...
12 KB (1,319 words) - 16:40, 17 July 2025
the -60 position. There are several AP-1 transcription factor binding sites in the viral LTRs. The closest AP-1 binding site is bound by the Jun and...
30 KB (3,765 words) - 07:43, 19 July 2025
T-box transcription factor T, also known as Brachyury protein, is encoded for in humans and other apes by the TBXT gene. Brachyury functions as a transcription...
36 KB (4,178 words) - 20:39, 16 July 2025
Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene. Sp4 transcription factor has been shown to interact with E2F1. GRCh38:...
7 KB (920 words) - 07:21, 19 July 2025
Protein c-Fos (category Transcription factors)
(part of Jun family of transcription factors), resulting in the formation of AP-1 (Activator Protein-1) complex which binds DNA at AP-1 specific sites at the...
26 KB (3,991 words) - 05:29, 10 July 2024
POU class 1 homeobox 1, also known as pituitary-specific positive transcription factor 1 (PIT1), POU domain, class 1, transcription factor 1 (POU1F1) and...
11 KB (1,372 words) - 18:38, 30 January 2024