• Thumbnail for Ciliary neurotrophic factor
    Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene. The protein encoded by this gene is a polypeptide hormone and neurotrophic...
    15 KB (1,748 words) - 16:47, 2 October 2024
  • unknown. The CNTF family of neurotrophic factors includes ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6),...
    16 KB (1,784 words) - 04:08, 6 January 2024
  • The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its cognate ligand support the...
    2 KB (146 words) - 00:52, 1 December 2023
  • Thumbnail for Glial scar
    also been shown to increase astrocyte proliferation in vitro. Ciliary neurotrophic factor (CNTF) is a cytosolic protein that is not secreted. CNTF has...
    24 KB (2,962 words) - 15:40, 7 June 2024
  • motility factor Bone morphogenetic proteins (BMPs) Ciliary neurotrophic factor family Ciliary neurotrophic factor (CNTF) Leukemia inhibitory factor (LIF)...
    10 KB (1,131 words) - 18:45, 6 May 2025
  • brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and ciliary neurotrophic factor (CNTF)...
    13 KB (1,184 words) - 07:26, 19 June 2025
  • Thumbnail for Nerve injury
    important role in not only producing neurotrophic factors such as nerve growth factor (NGF) and ciliary neurotrophic factor (CNTF), which promote growth, of...
    34 KB (4,120 words) - 18:50, 10 June 2025
  • Thumbnail for Neurotrophin
    to these four neurotrophins, the GDNF family of ligands, and ciliary neurotrophic factor (CNTF), among other biomolecules. Neurotrophin-6 and neurotrophin-7...
    28 KB (3,081 words) - 12:49, 24 May 2025
  • Thumbnail for Leukemia inhibitory factor receptor
    affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. Leukemia inhibitory factor receptor has been shown to interact...
    11 KB (1,325 words) - 16:37, 6 April 2024
  • Revakinagene taroretcel works by expressing recombinant human ciliary neurotrophic factor, which is a factor that may promote the survival and maintenance of the...
    7 KB (390 words) - 22:04, 29 May 2025
  • PKC pathways.[citation needed] CNTF: Ciliary neurotrophic factor is another protein that acts as a survival factor for motor neurons. CNTF acts via a receptor...
    53 KB (6,309 words) - 05:12, 9 June 2025
  • Thumbnail for Macular telangiectasia
    (neovascularisation), treatment with Anti-VEGF can be helpful. Ciliary neurotrophic factor (CNTF) is believed to have neuroprotective properties and could...
    20 KB (2,242 words) - 06:39, 2 June 2025
  • Thumbnail for Interleukin-6 receptor
    Interleukin-6 receptor has been shown to interact with Interleukin 6 and ciliary neurotrophic factor. Cluster of differentiation Anti-IL-6 Tocilizumab, a monoclonal...
    11 KB (1,446 words) - 18:05, 6 March 2025
  • Thumbnail for George Yancopoulos
    noteworthy from this period was the cloning of the receptor for the ciliary neurotrophic factor CNTF. The understanding of this receptor induced Yancopoulos...
    26 KB (2,634 words) - 13:07, 26 May 2025
  • Thumbnail for Retinal pigment epithelium
    insulin-like growth factor-1 (IGF-1), ciliary neurotrophic factor (CNTF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), lens...
    9 KB (1,193 words) - 03:55, 12 May 2025
  • Thumbnail for Interleukin 6
    Interleukin 6 (category Neurotrophic factors)
    Interleukin 27 (IL-27), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), leukemia inhibitory factor (LIF), oncostatin...
    63 KB (7,479 words) - 18:19, 9 June 2025
  • Thumbnail for CRLF1
    complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival...
    7 KB (931 words) - 16:56, 15 February 2024
  • Thumbnail for Paul A. Sieving
    group conducted the first human clinical trial of ciliary neurotrophic factor (CNTF) as a rescue factor for retinitis pigmentosa. His lab studies potential...
    8 KB (921 words) - 07:37, 3 December 2023
  • derived neurotrophic factor (GDNF), and ciliary neurotrophic factor (CNTF) was presented to Dorsal root ganglion cultures in vitro. One factor from each...
    106 KB (14,549 words) - 22:54, 1 July 2024
  • Thumbnail for Janus kinase 1
    IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R)...
    21 KB (2,343 words) - 03:15, 15 June 2025
  • include the cytokines interleukin 6 (IL-6), ciliary neurotrophic factor (CNTF), and leukemia inhibitory factor (LIF). Although many of these specific modulatory...
    30 KB (3,598 words) - 19:44, 13 July 2024
  • Zinc finger protein 91 homolog (mouse), ciliary neurotrophic factor transcription unit, also known as ZFP91-CNTF, is a human gene. The genes ZFP91 and...
    4 KB (509 words) - 09:07, 10 June 2024
  • Thumbnail for Interleukin 31
    includes IL-6, IL-11, IL-27, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like...
    10 KB (1,142 words) - 18:22, 2 October 2024
  • Thumbnail for Neurotrophin-3
    this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on...
    14 KB (1,820 words) - 07:02, 1 January 2025
  • Thumbnail for CLCF1
    closely related to other proteins called cardiotrophin-1 and ciliary neurotrophic factor. GRCh38: Ensembl release 89: ENSG00000175505 – Ensembl, May 2017...
    7 KB (861 words) - 23:29, 8 November 2023
  • Thumbnail for Interleukin 11 receptor alpha subunit
    receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure...
    8 KB (1,034 words) - 09:00, 2 November 2024
  • Thumbnail for Wallerian degeneration
    neurotrophic factor, ciliary neurotrophic factor, leukemia inhibitory factor, insulin-like growth factor, and fibroblast growth factor. These factors...
    42 KB (5,190 words) - 18:19, 10 June 2025
  • Thumbnail for Astrogliosis
    insult. Upregulation of GFAP, which is induced by FGF, TGFB, and ciliary neurotrophic factor (CNTF), is a classic marker for reactive gliosis. Axon regeneration...
    19 KB (2,176 words) - 12:51, 21 September 2024
  • and radial glial cells respond to extracellular trophic factors - like ciliary neurotrophic factor (CNTF), cytokines or neuregulin 1 (NRG1) - that can determine...
    18 KB (2,122 words) - 17:09, 23 February 2024
  • Successful experiments in animals have also been carried out using ciliary neurotrophic factor (CNTF), and CNTF is being used as a treatment in human clinical...
    40 KB (5,018 words) - 20:57, 29 May 2025