(+)-Discodermolide is a polyketide natural product found to stabilize microtubules. (+)-discodermolide was isolated by Gunasekera and his co-workers at...

has been employed in many total syntheses in the literature, such as discodermolide Evans–Tishchenko reaction Yang, Jaemoon (2008). "Diastereoselective...

chemists due to its production of a potent chemical compound called (+)-discodermolide, which has potential therapeutic applications for cancer treatment....

starting blocks for the synthesis of many targets including dictyostatin, discodermolide and spongidepsin. Shin, Youseung; Fournier, Jean-Hugues; Fukui, Yoshikazu;...

multidrug resistant cell lines. Discodermolide was initially found to have immunosuppressive and antifungal activities. Discodermolide is a polyhydroxylated alketetraene...

Kosan Biosciences was acquired by Bristol-Myers Squibb for $190M. Discodermolide is a recently discovered polyketide natural product found to be a potent...

dissoluta and the compound derived from it is Discodermolide. Pomponi and others researched if Discodermolide could also work as an immune suppressant and...

mechanisms still remain to be similar. One in particular is called, discodermolide. Dr. Horwitz and her team were interested in not only the binding site...

family (HSP90 inhibitors) The cholesterol lowering agent lovastatin Discodermolide Aflatoxin Usnic acid Anthracimycin Anthramycin Olivetolic acid (intermediate...

second methyl group was integrated by a C-methyl-transferase domain. Discodermolide Rosenberg, Steven; DeVita, Vincent T.; Hellman, Samuel (2005). Cancer:...

under investigation as possible therapies include the antitumour agents discodermolide (from the sponge Discodermia dissoluta), eleutherobin (from the coral...

is of interest to bio and organic chemists because it produces (+)-discodermolide, a polyketide natural product with immunosuppressive and cancer killing...

molecular glues took a significant turn in 1996 with the discovery that discodermolide stabilized the association of alpha and beta tubulin monomers, functioning...