High-mobility group AT-hook 2, also known as HMGA2, is a protein that, in humans, is encoded by the HMGA2 gene. This gene encodes a protein that belongs...

related to the cell cycle and proliferation, such as MYC, RAS, cyclin D, HMGA2, and CDC25A. Knockdown of these proteins by let-7 prevents proliferation...

rearrangements of the ALK gene, and occasionally with rearrangements of the HMGA2 gene. Tenosynovial giant cell tumor (not a sarcoma, but a non-metastasizing...

mobility AT-hook 2 gene (HMGA2) locus is significantly associated with variation in beak size (Lamichhaney et al. 2016). HMGA2 codes for a transcription...

suggests the involvement of other unknown genes. Chromosomal imbalances of HMGA2 (high mobility AT-hook 2) located on chromosome 12 have been implicated...

altering the chromatin architecture". Mammals have two orthologs: HMGA1 and HMGA2. In mouse embryonic stem cells it has been demonstrated that both HMGA proteins...

chromosomal architecture (caused by inappropriate expression of proteins such as HMGA2 or HMGA1). Each of these alterations regulates gene expression without altering...

the species became distinct. Genes for beak shape (ALX1) and beak size (HMGA2) have been determined to be crucial in separating the hybridized species...

caused by a loss of function (LOF) mutation in the High mobility AT-hook 2 (HMGA2) gene, spanning 12.1Kb from 44,709,089 bp to 44,721,236 bp that removes...

recurrence and it is currently regarded as a non-metastasizing benign tumor. HMGA2 rearrangement by translocation t(12;21)(q15;q21.1) by translocation t(11;12)(q23;q15)...

Hehir K, Fusil F, et al. (September 2010). "Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia". Nature. 467 (7313):...

characteristic functional domain: HMGA – contains an AT-hook domain HMGA1 HMGA2 HMGB – contains a HMG-box domain HMGB1 HMGB2 HMGB3 HMGB4 HMGN – contains...

PMID 12441356. Lemke I, Rogalla P, Grundmann F, et al. (2003). "Expression of the HMGA2-LPP fusion transcript in only 1 of 61 karyotypically normal pulmonary chondroid...

Hehir K, Fusil F, et al. (September 2010). "Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia". Nature. 467 (7313):...

Papillary thyroid carcinoma commonly metastasizes to cervical lymph nodes. HMGA2 has been proposed as a marker to identify malignant tumors. Treatment is...

repair enzyme MGMT may be a causal factor. HMGA proteins (HMGA1a, HMGA1b and HMGA2) are implicated in cancer, and expression of these proteins is regulated...

inactivate Rb family proteins. p16Ink4a and p19Arf expression are inhibited by Hmga2-dependent chromatin regulation. Many young adult stem cells are quiescent...

chromosomal architecture (caused by inappropriate expression of proteins such as HMGA2 or HMGA1) and changes caused by microRNAs. Each of these epigenetic alterations...

over the other, causing birds of the unfavorable bill size to die off. The HMGA2 gene locus is responsible for the evolution of beak size and plays an important...

decreased in cancers, rather than increased. HMGA2 protein could also have an effect on DNA-PKcs. HMGA2 delays the release of DNA-PKcs from sites of double-strand...

"The 12q14 microdeletion syndrome: six new cases confirming the role of HMGA2 in growth". European Journal of Human Genetics. 19 (5): 534–539. doi:10...

intermediary step involving the HMGA2 gene. The let-7a miRNA normally represses the HMGA2 gene, and in normal adult tissues, almost no HMGA2 protein is present. (See...

CDK4 genes, this band 13–15 chromosome area also contains the TSPAN31 and HMGA2 genes which, when overexpressed, are associated with various tumors and/or...

through alterations of chromosome architecture caused by proteins such as HMGA2. A further source of epimutation is due to increased or decreased expression...

cell growth. NFKB1 has been shown to interact with: BCL3, C22orf25, HDAC1, HMGA2 IKK2, ITGB3BP, IκBα, LYL1, MAP3K7IP2, MAP3K8, MEN1, NFKB2, NFKBIE, NOTCH1...

HGNC:5001 Q9NP66 7117 HMG20B HGNC:5002 Q9P0W2 7118 HMGA1 HGNC:5010 P17096 7119 HMGA2 HGNC:5009 P52926 7120 HMGB1 HGNC:4983 P09429 7121 HMGB2 HGNC:5000 P26583...

ENSG00000137309 AT hook Known motif – In vivo/Misc source [361] WATTWW HMGA2 ENSG00000149948 AT hook Known motif – In vivo/Misc source [362] ATATTSSSSDWWAWT...

intermediate size and shape. IGF1R (Insulin-like growth factor 1 receptor) and HMGA2 (High-mobility group AT-hook 2) are incomplete dominant with delicate dwarfs...

double-strand break and PARP-1 was involved in replacing histone H1 by HMGB1/HMGA2, which can promote transcription. Topo IIβ and PARP-1 increased at the site...

to the "identification of the first gene implicated in uterine fibroids, HMGA2." Dr. Morton’s research focuses on using genetic information to differentiate...