• Thumbnail for Low-affinity nerve growth factor receptor
    The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR...
    37 KB (4,235 words) - 04:17, 19 March 2025
  • Thumbnail for Nerve growth factor
    Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival...
    27 KB (3,110 words) - 06:33, 25 May 2025
  • neurotrophic factor receptors are the p75 and the "Trk" families of tyrosine kinase receptors. p75 is a low affinity neurotrophin receptor, to which all...
    5 KB (670 words) - 10:25, 10 April 2025
  • Thumbnail for Brain-derived neurotrophic factor
    responding to this growth factor, TrkB (pronounced "Track B") and the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). It may...
    50 KB (5,881 words) - 13:31, 5 May 2025
  • Thumbnail for Epidermal growth factor
    Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has...
    17 KB (1,716 words) - 11:48, 25 May 2025
  • agonist of the tropomyosin receptor kinase A (TrkA) and low-affinity nerve growth factor receptor (p75NTR). The most common side effects include eye pain...
    7 KB (389 words) - 08:54, 17 February 2025
  • Thumbnail for Tropomyosin receptor kinase A
    Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming...
    28 KB (3,328 words) - 15:54, 29 October 2024
  • Thumbnail for Tropomyosin receptor kinase C
    is one other NT-3 receptor family besides the Trks (TrkC & TrkB), called the "LNGFR" (for "low affinity nerve growth factor receptor"). As opposed to TrkC...
    30 KB (3,901 words) - 00:12, 24 May 2025
  • Thumbnail for Cell surface receptor
    High affinity neurotrophin receptors Ephrin receptors Integrins Low Affinity Nerve Growth Factor Receptor NMDA receptor Several Immune receptors Toll-like...
    22 KB (2,480 words) - 14:02, 24 March 2025
  • Thumbnail for Hepatocyte growth factor receptor
    Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity...
    59 KB (6,731 words) - 05:32, 23 May 2025
  • Thumbnail for George Yancopoulos
    receptor for BDNF, and showed that they were sufficient to mediate signaling without the requirement of the Low affinity Nerve Growth Factor receptor...
    26 KB (2,634 words) - 13:07, 26 May 2025
  • Thumbnail for Neurotrophin-3
    binds a second-receptor type besides Trk receptors, called the LNGFR (for "low affinity nerve growth factor receptor). TrkC is a receptor tyrosine kinase...
    14 KB (1,820 words) - 07:02, 1 January 2025
  • Thumbnail for Neurotrophin
    of receptors for neurotrophins: p75 and the "Trk" family of Tyrosine kinases receptors. Nerve growth factor (NGF), the prototypical growth factor, is...
    28 KB (3,081 words) - 12:49, 24 May 2025
  • Vascular endothelial growth factor (VEGF, /vɛdʒˈɛf/), originally known as vascular permeability factor (VPF), is a signal protein produced by many cells...
    40 KB (4,578 words) - 12:30, 10 September 2024
  • Thumbnail for Fibroblast growth factor receptor 2
    This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. FGFR2 has important...
    14 KB (1,745 words) - 09:02, 15 July 2024
  • Thumbnail for Tropomyosin receptor kinase B
    Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type...
    39 KB (4,393 words) - 05:21, 26 March 2025
  • Thumbnail for Placental growth factor
    Placental growth factor (PlGF) is a protein that in humans is encoded by the PGF gene. Placental growth factor is a member of the VEGF (vascular endothelial...
    15 KB (1,867 words) - 09:38, 20 April 2025
  • sufficient to mediate signaling without the requirement of the Low affinity Nerve Growth Factor receptor (LNGFR). Glass identified the E3 ubiquitin ligases, MuRF1...
    11 KB (1,056 words) - 22:59, 24 May 2025
  • Thumbnail for Olfactory ensheathing cell
    OECs have been identified with high or low cell surface expression of low-affinity nerve growth factor receptor (p75). Neuroscience Neuroglia Olfaction...
    18 KB (2,263 words) - 21:54, 8 March 2025
  • Thumbnail for Fibroblast growth factor receptor 3
    Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster...
    17 KB (1,844 words) - 17:02, 8 May 2025
  • inhibitory factor receptor Leukocyte extravasation Leukocyte-promoting factor Linear epitope Lipid A Lipopolysaccharide binding protein Low-affinity nerve growth...
    13 KB (1,237 words) - 01:24, 15 January 2024
  • Thumbnail for Somatostatin
    Pasireotide is somatostatin analog with a 40-fold increased affinity to somatostatin receptor 5 compared to other somatostatin analogs. Six somatostatin...
    23 KB (2,531 words) - 13:11, 14 April 2025
  • Thumbnail for NDN (gene)
    has been shown to interact with: E2F1, HNRNPU, IL1A, Low affinity nerve growth factor receptor, NUCB2, and P53 ENSG00000288364 GRCh38: Ensembl release...
    11 KB (1,275 words) - 09:54, 13 March 2025
  • Thumbnail for GRB2
    Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2...
    82 KB (9,365 words) - 09:44, 2 March 2025
  • Thumbnail for Μ-opioid receptor
    The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins...
    49 KB (4,886 words) - 04:07, 28 April 2025
  • Thumbnail for Pleiotrophin
    heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated...
    14 KB (1,649 words) - 07:53, 21 December 2023
  • Thumbnail for Co-receptor
    into co-receptors for p75, such as the sortilin co-receptor, has implicated sortilin in connection to neurotrophins, a type of nerve growth factor. The p75...
    21 KB (3,129 words) - 01:57, 6 February 2025
  • Thumbnail for Cannabinoid receptor
    function in keratinocytes. They are also expressed on peripheral nerve terminals. These receptors play a role in antinociception, or the relief of pain. In the...
    32 KB (3,086 words) - 18:05, 24 February 2025
  • Thumbnail for Leukotriene B4 receptor 2
    and therefore has been termed the low affinity LTB4 receptor. Sometime after its initial discovery, the BLT2 receptor was shown to bind and become activated...
    51 KB (6,698 words) - 08:55, 29 September 2024
  • Thumbnail for Eosinophil
    granules, which show their affinity for acids by their affinity to coal tar dyes: Normally transparent, it is this affinity that causes them to appear...
    29 KB (3,165 words) - 14:14, 27 March 2025