Platelet transfusion refractoriness is the repeated failure to achieve the desired level of blood platelets in a patient following a platelet transfusion...

types), febrile non-hemolytic transfusion reaction, cytomegalovirus infection, and platelet-transfusion refractoriness. Pathogen reduction treatment that...

characterized by abnormally low levels of platelets (also known as thrombocytes) in the blood. Low levels of platelets in turn may lead to prolonged or excessive...

to demonstrate an adequate post-transfusion increment, this is termed platelet transfusion refractoriness. Platelets, either apheresis-derived or random-donor...

CCI is less than 5,000/μL, patients are said to have "refractoriness" to platelet transfusion. The separation of individual blood components is done...

one of the causes of hemolytic disease of the newborn Transfusion reaction to blood transfusions Mechanical trauma to red blood cells Microangiopathic...

not requiring a transfusion). Romiplostim and eltrombopag are thrombopoeitin receptor agonists which act on megakaryocytes (platelet precursor cells)...

cases of platelet transfusion refractoriness to infusion of donor platelets. A nomenclature was devised by International Society of Blood Transfusion (ISBT)...

Platelet-rich plasma (PRP), also known as autologous conditioned plasma, is a concentrate of plasma protein derived from whole blood, centrifuged to remove...

remedies. Platelet transfusion alone is normally not recommended except in an emergency and is usually unsuccessful in producing a long-term platelet count...

treatment of massive bleeding, in exchange transfusion, and when people donate blood to themselves (autologous transfusion). One unit of whole blood (approximately...

2015). "Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people...

Immunosuppressants, such as glucocorticoids, and rituximab may also be used. Platelet transfusions are generally not recommended. About 1 per 100,000 people are affected...

the equivalent of between six and ten random platelet concentrates. Quality control demands the platelets from apheresis be equal to or greater than 3...

amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness". Blood. 79 (11): 3086–3090. doi:10.1182/blood.V79.11.3086...

(ed.). "Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people...

pronounced effect in reducing mitral regurgitation Patients will need dual anti-platelet therapy for 6 months or more. Within the next 6 months, patients will need...

physician-scientist whose work on platelet and red blood cell transfusion and cord blood transplantation earned her transfusion medicine’s three highest honors:...

inhibitor of the protein-protein interaction between fibrinogen and the platelet integrin receptor GP IIb/IIIa and is the first drug candidate whose origins...

and oxygen supplementation for hypoxia. Blood transfusion may also be required, or exchange transfusion in severe cases. When treating avascular necrosis...

and megakaryocytes. The latter are responsible for the production of platelets. Signs and symptoms include fever, night sweats, bone pain, fatigue, and...

spherocytosis (in cases of direct Coombs test, DCT, positive haemolytic anaemia). Platelet counts may be reduced, increased or normal. Haemoglobin levels are usually...

multiple platelet transfusions, continued to exhibit low platelet levels. This condition is known as refractoriness to platelet transfusion. Subsequent...

2015). "Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people...

Vincent, Jean-Louis; Creteur, Jacques; Taccone, Fabio Silvio (2018). "Platelet indices and outcome after cardiac arrest". BMC Emergency Medicine. 18 (1):...

(ed.). "Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people...

activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system (HPA15), implicated in refractoriness to platelet transfusion, neonatal...

Sherrill Slichter is an American physician whose work on platelet biology earned her transfusion medicine’s three highest honors: the AABB Karl Landsteiner...

Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with...

headache, and trouble sleeping. Severe side effects include low blood platelets, low white blood cells, and blood clots. The dose may need to be adjusted...