• Retrosynthetic analysis is a technique for solving problems in the planning of organic syntheses. This is achieved by transforming a target molecule into...
    9 KB (986 words) - 22:18, 23 May 2025
  • In retrosynthetic analysis, a synthon is a hypothetical unit within a target molecule that represents a potential starting reagent in the retroactive...
    7 KB (816 words) - 21:30, 24 February 2025
  • processes. Key components of natural product synthesis include retrosynthetic analysis, which involves planning synthetic routes by working backward from...
    22 KB (2,203 words) - 21:09, 12 March 2025
  • Thumbnail for Elias James Corey
    the theory and methodology of organic synthesis", specifically retrosynthetic analysis. Regarded by many as one of the greatest living chemists, he has...
    56 KB (5,744 words) - 06:25, 14 June 2025
  • Thumbnail for Functional group
    groups nearby. Functional group interconversion can be used in retrosynthetic analysis to plan organic synthesis. A functional group is a group of atoms...
    32 KB (1,230 words) - 18:58, 12 June 2025
  • umpolung for reversed polarity) and E.J. Corey. Polarity analysis during retrosynthetic analysis tells a chemist when umpolung tactics are required to synthesize...
    14 KB (1,784 words) - 16:19, 18 November 2024
  • synthesis Petrochemistry Physical organic chemistry Polymer chemistry Retrosynthetic analysis Stereochemistry Alkane stereochemistry Total synthesis / Semisynthesis...
    20 KB (2,260 words) - 13:17, 23 May 2025
  • of the most stable products. Advanced Planning and Techniques: Retrosynthetic analysis is a strategy used to plan complex syntheses by breaking down the...
    11 KB (1,128 words) - 14:30, 25 May 2025
  • chemistry Organic reaction Organic compound Organic synthesis Retrosynthetic analysis Current trends in organic chemistry include (as of 2020): Biocatalysis...
    8 KB (574 words) - 12:46, 7 March 2025
  • sinus arrhythmia, the heart rate variation due to respiration Retrosynthetic analysis, in organic chemistry Rsa RNA, partially characterised non-coding...
    3 KB (420 words) - 00:59, 13 March 2025
  • Thumbnail for Chemical reaction
    often with a minus sign. Retrosynthetic analysis can be applied to design a complex synthesis reaction. Here the analysis starts from the products, for...
    66 KB (8,057 words) - 01:14, 16 June 2025
  • Thumbnail for Pinacolone
    fungicides, herbicides, and pesticides. Some derivatives include: retrosynthetic analysis of vibunazole showed that it was derived from pinacolone. It is...
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  • Thumbnail for Hyperforin
    enantioselective total synthesis of the correct enantiomer was disclosed. The retrosynthetic analysis was inspired by hyperforin's structural symmetry and biosynthetic...
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  • Thumbnail for Ene reaction
    F. M. (2012). "Alder-ene reaction: Aromaticity and activation-strain analysis". Journal of Computational Chemistry. 33 (5): 509–516. doi:10.1002/jcc...
    25 KB (3,164 words) - 08:36, 1 June 2025
  • Thumbnail for Retrometabolic drug design
    design was coined by Nicholas Bodor. The method is analogous to retrosynthetic analysis where the synthesis of a target molecule is planned backwards....
    23 KB (2,829 words) - 06:09, 15 August 2023
  • Thumbnail for Holton Taxol total synthesis
    Retrosynthetic analysis for the Holton Taxol total synthesis....
    16 KB (1,478 words) - 23:58, 18 February 2025
  • Thumbnail for Epothilone
    below and was described by the laboratory of K. C. Nicolaou. The retrosynthetic analysis revealed 1, 2, and 3 as the building blocks (Figure 1). As seen...
    21 KB (2,166 words) - 14:49, 24 May 2025
  • 19770600329. Zahedi Ehsan; Ali-Asgari Safa; Keley Vahid (2010). "NBO and NICS analysis of the allylic rearrangements (the Cope and 3-aza-Cope rearrangements)...
    50 KB (5,704 words) - 20:45, 22 July 2024
  • synthesis Petrochemistry Physical organic chemistry Polymer chemistry Retrosynthetic analysis Stereochemistry Alkane stereochemistry Total synthesis / Semisynthesis...
    10 KB (1,206 words) - 05:47, 31 January 2025
  • work has been instrumental in the development of computer-aided retrosynthetic analysis and had significant impact on the development of chemoinformatics...
    9 KB (849 words) - 17:18, 23 May 2025
  • B.; Watson, Stephen P.; Hann, Michael M. (1998). "RECAP-Retrosynthetic Combinatorial Analysis Procedure: A Powerful New Technique for Identifying Privileged...
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  • Steensma, David P (January 2013). "Elias James Corey—Nobel Prize for Retrosynthetic Analysis". Stamp Vignette on Medical Science. 88 (1): E7. Retrieved 2024-09-19...
    90 KB (3,983 words) - 01:24, 5 June 2025
  • Thumbnail for Thiostrepton
    C, Zécri FJ, Bulat S (2005). "Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks". J. Am. Chem. Soc. 127...
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  • Thumbnail for Kedarcidin
    by Hirama et al. Critical to the success of this endeavor was retrosynthetic analysis that focused on the convergent coupling of components with roughly...
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  • Thumbnail for Avasimibe
    degradation products.) Chemical modification of PD 138142-15 and retrosynthetic analysis found that avasimibe (then codenamed CI-1011) could be easily manufactured...
    11 KB (1,128 words) - 15:19, 24 October 2024
  • stereoselective synthesis. Many synthetic procedures are developed from a retrosynthetic framework, a type of synthetic design developed by Elias James Corey...
    25 KB (2,550 words) - 17:17, 25 May 2025
  • Thumbnail for LSD
    nature and are not formed during the synthesis from d-lysergic acid. Retrosynthetically, the C-5 stereocenter could be analysed as having the same configuration...
    236 KB (23,219 words) - 15:27, 12 June 2025
  • hydride, is a more favorable process. In broad strokes, and in a formal retrosynthetic sense, titanacyclopropane 1 behaves like a 1,2-dianion which adds into...
    16 KB (1,697 words) - 09:44, 25 May 2025
  • moieties from databases of chemical structures. RECAP (Retrosynthetic Combinatorial Analysis Procedure) uses SMARTS to define bond types. RECAP is a...
    14 KB (1,749 words) - 23:51, 23 March 2025
  • Thumbnail for Hong-Cai (Joe) Zhou
    metalation", "linker migration", "domino lattice rearrangement", and "retrosynthetic design". These contributions form the aforementioned "toolkit" for MOF...
    15 KB (1,606 words) - 00:13, 23 May 2025