Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene. SOX-9 recognizes the sequence CCTTGAG along with other members of the...

that causes upregulation of other transcription factors, most importantly SOX9. Its expression causes the development of primary sex cords, which later...

nucleotide variants been identified involving the SOX9 gene that cause some form of CMD. The SOX9 gene codes for a protein transcription factor which...

tissue while the poles both contain ovarian tissue. Experiments involving the SOX9 gene, which is initiated by the SRY region of the Y chromosome, have shown...

during development. TDF functions by activating the SOX9 gene on chromosome 17, so mutations of the SOX9 gene can cause humans with an ordinary Y chromosome...

example, it has been proposed that mutations in the SOX9 gene may contribute to this syndrome, as SOX9 plays a role in testes differentiation during development...

the sex-determining region of the Y-chromosome, the SRY. The SRY activates Sox9, which forms feedforward loops with FGF9 and PGD2 in the gonads, allowing...

cases, the SOX9 gene, involved in the development of testes, can induce their development without the aid of SRY. In the absence of SRY and SOX9, no testes...

mutation was described by Bohlen et al. (2017) in a Kozak-like region in the SOX9 gene that created a new translation initiation codon in an out-of-frame open...

there are normal sex chromosomes in XX females, duplication or expression of SOX9 causes testes to develop. Gradual sex reversal in developed mice can also...

(possibly at the SOX9 gene or the KCNJ2 gene) have all been implicated in PRS. Some evidence suggests that genetic dysregulation of the SOX9 gene (which encodes...

violation. SRY acts on gene SOX9 which drives Sertoli cell formation and testis differentiation. An absence in SRY causes SOX9 to not be expressed at the...

structure. Sox9, L-Sox5 and Sox6 are needed for the osteochondroprogenitor to undergo chondrocytic differentiation. The transcription factor Sox9 can be found...

close to Hh-expressing ventral nerve cords and expresses ColA and SoxE, a Sox9 analog. This is also seen in gill cartilage tissue. In cephalopods, the models...

attributing specific cases of the condition to some form of duplication of the SOX9 gene; making this an incredibly rare cause. Note: The SRY gene has a 8 to...

receptor is encoded by the AMHR2 gene on chromosome 12. AMH is activated by SOX9 in the Sertoli cells of the male fetus. Its expression inhibits the development...

genes above, non-hypermutated samples also contain mutated CTNNB1, FAM123B, SOX9, ATM, and ARID1A. Progressing through a distinct set of genetic events, hypermutated...

series of events starting with the upregulation of the transcription factor (SOX9), and in other areas not being active (causing the growth of ovarian tissues)...

of the L-Sox5, Sox6, Sox9 and Nkx3.2. Sox9 and Nkx3.2 induce each other in a positive feedback loop where Nkx3.2 inactivates a Sox9 inhibitor. This loop...

determination by downstream regulation of sex-determining factors (such as GATA4, SOX9 and AMH), which lead to development of the male phenotype, including directing...

differentiation of pluripotent stem cells as well as the loss of DNA methylation. SOX9 recruits histone modification enzymes MLL3 and MLL4 to deposit H3K4me1 prior...

in Fluorescence Recovery After Photobleaching (FRAP) as an indicator of SOX9 transcription factor activity". Biochimica et Biophysica Acta (BBA) - Gene...

XY mice, there is less expression of SRY and a reduction in the amount of SOX9. Moreover, defects in vascularization are found. These occurrences result...

loop with Sox9, which is activated by the SRY of the Y chromosome. PGD2, in a different feedforward loop than FGF9, helps keep the level of SOX9 high enough...

cells, the treatment showed increased expression of the transcription factor Sox9, which plays a key role in chondrogenesis, the process of cartilage formation...

mandibular fossa develops from condylar cartilage. This may be stimulated by SOX9 or ALK2, as has been seen in mouse models. The condyloid process of the mandible...

"Serine racemase suppresses chondrogenic differentiation in cartilage in a Sox9-dependent manner". Journal of Cellular Physiology. 215 (2): 320–328. doi:10...

Tripuraneni, N; Hegde, NV; Lieberman, JR; Crump, JG; Mariani, FV (2019). "Sox9+ messenger cells orchestrate large-scale skeletal regeneration in the mammalian...

polymerization also regulates Sox9 expression via controlling transcriptional Sox9 activity. The expression and transcriptional activity of Sox9 is directly linked...

the morphogen sonic hedgehog, and transcription factors such as sox2 and sox9. Recent research has suggested that most foregut malformations are due to...