The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic...

anchoring of chromosomes to MTs in the spindle, verification of anchoring, activation of the spindle checkpoint and participation in the generation of...

the G2/M checkpoint; and the metaphase-to-anaphase transition, also known as the spindle checkpoint. Progression through these checkpoints is largely...

Mad2 (mitotic arrest deficient 2) is an essential spindle checkpoint protein. The spindle checkpoint system is a regulatory system that restrains progression...

prevent deleterious nondisjunction events, a key cell cycle checkpoint, the spindle checkpoint, verifies this evenly balanced alignment and ensures that...

cyclins. CDC20 is also a part of, and regulated by, the spindle assembly checkpoint (SAC). This checkpoint ensures that anaphase proceeds only when the centromeres...

damage checkpoint M spindle checkpoint, prevents anaphase onset until all chromosomes are properly attached to the spindle Immune checkpoint Application...

one of three main cell cycle checkpoints, the other two being the G2-M DNA damage checkpoint and the spindle checkpoint. Originally, Howard Martin Temin...

to the mitotic spindle by the time of this checkpoint, the onset of anaphase will be delayed. Failure of this spindle assembly checkpoint can result in...

BubR1, this protein is recognized for its mitotic roles in the spindle assembly checkpoint (SAC) and kinetochore-microtubule interactions that facilitate...

the spindle checkpoint system contributes to the delay if it needs to correct the bi-orientation of chromosomes. Though how the spindle checkpoint system...

Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene. Bub3 is a protein involved with the regulation of the Spindle Assembly...

localization to the cleavage furrow and disrupts spindle midzone organization. The spindle assembly checkpoint inhibits progression of mitosis from metaphase...

yeast has a function in the spindle assembly checkpoint (SAC). This checkpoint monitors chromosome attachment to spindle microtubules and prevents cells...

purpose for this checkpoint is to check for appropriate cell size and any DNA damage . The second check point is in the G2 phase, this checkpoint also checks...

for spindle checkpoint. Types include: Also those genes are associated with that disorder: BUB3 and BUB1. BUB1, BUB1B and BUB3 participates in spindle checkpoint...

role in the establishment of the mitotic spindle checkpoint and chromosome congression. The mitotic checkpoint kinase is evolutionarily conserved in organisms...

are three checkpoints in the cell cycle: the G1/S Checkpoint or the Start checkpoint in yeast; the G2/M checkpoint; and the spindle checkpoint. During G1...

Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene. MAD2L1 is a component of the mitotic spindle assembly...

when most of the other chromosomes have lined up, will trigger the spindle checkpoint signal. This prevents premature progression into anaphase by inhibiting...

Following bi-orientation of chromosome pairs and inactivation of the spindle checkpoint system, the underlying regulatory system, which includes securin,...

cell cycle, defective DNA or chromatin metabolism, failure in the spindle checkpoint, etc.) would generate a failure in cell division, an increase in ploidy...

system such that we have three designated checkpoints to account for this: G1/S, G2/M, and the spindle checkpoint. Irreversible hysteresis in this context...

of cell division at the spindle assembly checkpoint (SAC). However, as numerous and varied as they are, spindle poisons are not yet 100% effective at ending...

biochemical feature of this checkpoint is the activation of M-phase cyclin-CDK complexes, which phosphorylate proteins that promote spindle assembly and bring...

arrest at the G2 phase. Chk1 has a role in the spindle checkpoint during mitosis thus interacts with spindle assembly proteins Aurora A kinase and Aurora...

and MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity. Humans...

Mitotic spindle assembly checkpoint protein MAD1 is a protein that in humans is encoded by the MAD1L1 gene. MAD1L1 is also known as Human Accelerated...

important protein of the spindle checkpoint. Also, VHL colocalizes with the microtubule. Thus VHL loss leads to a weakened checkpoint and subsequently chromosome...

The spindle checkpoint (also referred to as the mitotic checkpoint) ensures proper separation of chromosomes. Broadly, the mitotic checkpoint promotes...