Thymidylate synthase (TS) (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate...
16 KB (1,902 words) - 00:29, 10 March 2024
In enzymology, a thymidylate synthase (FAD) (EC 2.1.1.148) is an enzyme that catalyzes the chemical reaction 5,10-methylenetetrahydrofolate + dUMP + FADH2...
3 KB (244 words) - 21:45, 25 April 2025
Thymidylate synthase inhibitors are chemical agents which inhibit the enzyme thymidylate synthase and have potential as an anticancer chemotherapy. This...
4 KB (380 words) - 00:05, 20 March 2025
Raltitrexed (category Thymidylate synthase inhibitors)
antimetabolite drug used in cancer chemotherapy. It is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca. Used in treatment of colorectal...
5 KB (311 words) - 21:24, 14 July 2024
Fluorouracil (category Thymidylate synthase inhibitors)
entirely clear, but it is believed to involve blocking the action of thymidylate synthase and thus stopping the production of DNA. Fluorouracil was patented...
34 KB (3,131 words) - 16:55, 29 March 2025
Capecitabine is metabolised to 5-FU which in turn is a thymidylate synthase inhibitor, hence inhibiting the synthesis of thymidine monophosphate...
17 KB (1,401 words) - 16:39, 12 January 2025
(where uracil is used instead), inhibition of thymidine synthesis via thymidylate synthase selectively inhibits DNA synthesis over RNA synthesis. Due to their...
11 KB (1,239 words) - 19:07, 30 January 2025
with the alpha-subunit of tryptophan (TSA) synthase to yield indole. The beta-subunit of tryptophan synthase (TSB) catalyzes condensation of indole with...
25 KB (2,517 words) - 19:48, 6 March 2025
methyl group onto the uracil base of dUMP to generate dTMP. The thymidylate synthase reaction, dUMP + 5,10-methylenetetrahydrofolate ⇔ dTMP + dihydrofolate...
61 KB (6,770 words) - 20:03, 8 March 2025
Kitamura H, Nomura N, Danenberg PV, Kubota Y (2005). "Expression of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate...
28 KB (3,560 words) - 20:45, 22 July 2024
pyrimidines. Nucleobase analogues Fluorouracil (5FU), which inhibits thymidylate synthase Floxuridine (FUDR) 6-azauracil (6-AU) Nucleoside analogues Cytarabine...
1 KB (83 words) - 04:27, 4 June 2024
2CCJ, 2CCK, 2PBR, 2TMK, 3TMK, 4TMK, and 5TMP. Thymidine kinase Thymidylate synthase Thymidine kinase in clinical chemistry Li C, Huang SH, Tang A, Drisco...
4 KB (350 words) - 06:28, 29 November 2023
aspartate transporter Pyrimidine metabolism Dihydroorotate dehydrogenase Thymidylate synthase (FAD) HtrA serine peptidase 2 Adrenodoxin reductase Heme biosynthesis...
9 KB (908 words) - 06:53, 28 February 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
24 KB (2,138 words) - 03:59, 28 April 2025
aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease...
41 KB (4,582 words) - 05:09, 1 April 2025
Fluorodeoxyuridylate (category Thymidylate synthase inhibitors)
5-fluorouracil and 5-fluorodeoxyuridine. FdUMP acts as a suicide inhibitor of thymidylate synthase (TS). By inhibiting the deoxynucleotide biosynthesis, FdUMP stops...
11 KB (1,304 words) - 20:08, 18 October 2024
used instead. dTTP is synthesized via the methylation of dUMP via thymidylate synthase. It can be used by DNA ligase to create overlapping "sticky ends"...
3 KB (159 words) - 23:24, 17 July 2024
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
11 KB (865 words) - 18:55, 13 April 2025
ribonucleotide reductase (see next section). dUMP is then methylated by thymidylate synthase to produce thymidine monophosphate (TMP). The regulation of pyrimidine...
14 KB (1,511 words) - 19:28, 25 March 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
33 KB (3,152 words) - 18:41, 25 April 2025
It bypasses several metabolic steps in the body and better binds thymidylate synthase with FdUMP, a metabolite of the drug fluorouracil. In March 2012...
14 KB (1,131 words) - 19:48, 29 April 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
20 KB (1,816 words) - 04:09, 22 March 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
17 KB (1,666 words) - 18:58, 5 May 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
13 KB (921 words) - 16:50, 12 January 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
12 KB (1,037 words) - 20:00, 30 January 2025
carbamoyltransferase that is not present in plants, and plants have a fusion of thymidylate synthase and dihydrofolate reductase not present in the opisthokonts. Animals...
20 KB (1,418 words) - 03:00, 5 May 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
18 KB (1,740 words) - 08:32, 17 April 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
32 KB (2,944 words) - 16:04, 9 January 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
63 KB (6,259 words) - 02:46, 7 April 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
12 KB (1,281 words) - 11:43, 11 February 2025