Vesicle fusion is the merging of a vesicle with other vesicles or a part of a cell membrane. In the latter case, it is the end stage of secretion from...

After the synaptic vesicles initially dock, they must be primed before they can begin fusion. Priming prepares the synaptic vesicle so that they are able...

cell biology, a vesicle is a structure within or outside a cell, consisting of liquid or cytoplasm enclosed by a lipid bilayer. Vesicles form naturally...

Kiss-and-run fusion is a type of synaptic vesicle release where the vesicle opens and closes transiently. In this form of exocytosis, the vesicle docks and...

vesicle fusion is in close proximity to calcium channels and that vesicle fusion is adjacent to postsynaptic receptors. This close proximity vesicle fusion...

to mediate the fusion of vesicles with the target membrane; this notably mediates exocytosis, but can also mediate the fusion of vesicles with membrane-bound...

specialized SNARE protein complexes that enable vesicle docking and fusion. Following release, synaptic vesicles are recycled through multiple pathways to maintain...

the fusion complex. SNAPs are involved in the priming of the vesicle fusion complex during assembly, as well as in the disassembly following a vesicle fusion...

facilitator of synaptic vesicle fusion and neurotransmitter release. In one conformation, it clamps SNAREpin complexes, preventing vesicle fusion, while in a different...

vesicle transport, earning the Nobel Prize in Physiology or Medicine in 2013. Their research elucidated the mechanisms of vesicle trafficking, fusion...

where secretory vesicles transiently dock in the process of vesicle fusion and secretion. The transient fusion of secretory vesicle membrane at a porosome...

in vitro with synthetic lipid vesicles. These studies have shown that divalent cations play a critical role in the fusion process by binding to negatively...

footprint (bright spots in the top cell in the right panel). An example of vesicle fusion in chromaffin cells using IRM is shown in movie 1. Upon stimulation...

involved in vesicle trafficking, specifically the tethering and spatial targeting of post-Golgi vesicles to the plasma membrane prior to vesicle fusion. It is...

insulin is cleaved from proinsulin in the secretory vesicles). Eventually, there is vesicle fusion with the cell membrane at porosomes, by a process called...

Vesicle associated membrane proteins (VAMPs) are a family of SNARE proteins with similar structure, and are mostly involved in vesicle fusion. VAMP1 and...

proteins have been identified as essential components of the synaptic vesicle fusion protein complex and are crucial for the regulated exocytosis of neurons...

nanoheater at the interface between two membrane vesicles, or two cells, leads to immediate fusion of the two verified by both content and lipid mixing...

localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. VAMP-7 has been shown to interact...

accounts for membrane fusion specificity and directly executes fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes...

ions bind to sensor proteins (synaptotagmins) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release...

proteins underlying vesicle fusion. This cell line has been used to understand the role of synaptotagmin in vesicle-cell membrane fusion. Their embryological...

the vesicle for the neuron cytosol, where it cleaves vesicle associated membrane protein (VAMP) synaptobrevin, which is necessary for membrane fusion of...

nervous system tissues. Vesicle fusion events involved in neurotransmitter trafficking also relies on the catalytic activity of fusion proteins. The SNARE...

the calcium-dependent triggering of synaptic vesicle fusion with plasma membrane. These synaptic vesicles contain acetylcholine, which is released into...

increasing cytosolic Ca2+ concentration, resulting in vesicle fusion and release of secretory vesicles containing premade growth hormone. Some Ca2+ influx...

for NSF binding. Synaptobrevin is an integral V-SNARE necessary for vesicle fusion to membranes. The final target of TeNT is the cleavage of synaptobrevin...

synaptic vesicle docking to the presynaptic membrane via interaction with β-neurexin or SNAP-25 Late steps of Ca2+-evoked synaptic vesicle fusion with the...

by motor proteins. Once the vesicle arrives at its destination it joins with the bi-lipid layer in a process called fusion, and then releases its contents...

encoded protein may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. It is...