serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases...
24 KB (2,850 words) - 04:05, 29 September 2022
to PKB alpha and Akt1 alone.[citation needed] Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce...
34 KB (3,754 words) - 20:14, 23 April 2024
for the disorder, Lindhurst et al. identified an activating mutation in AKT1 kinase in a mosaic state. Previous research had suggested the condition linked...
18 KB (1,926 words) - 15:43, 19 May 2024
set of transcription factors perturbed by AKT1 activation. These results incriminate somatic mutations of AKT1 as probable driver events in the pathogenesis...
12 KB (1,249 words) - 19:55, 3 December 2023
2-negative locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN-alterations, as detected by an FDA-approved test, following progression...
10 KB (608 words) - 22:53, 17 May 2024
and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP...
12 KB (1,431 words) - 17:47, 28 October 2022
isozymes, Akt1, Akt2 and Akt3. Small-molecule inhibitors of Akt1 could be especially useful to target tumors with a high prevalence of Akt1 E17K activating...
36 KB (4,322 words) - 16:42, 6 October 2023
in ovarian cancer subtypes Gene mutated Mutation type Subtype Prevalence AKT1 amplification 3% AKT2 amplification/mutation 6%, 20% ARID1A point mutation...
194 KB (20,745 words) - 23:11, 15 May 2024
ÄKT), a Finnish music organization Karat (airline) (ICAO: AKT), in Russia AKT1, AKT2, or AKT3, enzymes Erich Akt (1898–?), German politician Akolet language...
1 KB (180 words) - 08:25, 13 February 2022
L'histoire du soldat The Devil/Narrator Copenhagen Phil 2015 Danske Permafrost AKT1 Danmarks Lydteater Live in the Dome of Visions, Copenhagen The Evil Erik...
36 KB (2,054 words) - 11:13, 7 June 2024
COX-2, respectively. HoxA5 also upregulates the tumor suppressor p53 and Akt1 by downregulation of PTEN. Suppression of HoxA5 has been shown to attenuate...
42 KB (4,469 words) - 17:00, 1 April 2024
highly selective inhibitor of pan-Akt, namely, of all three Akt isoforms Akt1, Akt2, and Akt3. It is intended to be used with other cancer therapies that...
5 KB (376 words) - 06:37, 13 March 2023
resveratrol had been identified, including NQO2 (alone and in interaction with AKT1), GSTP1, estrogen receptor beta, CBR1, and integrin αVβ. It was unclear at...
40 KB (3,847 words) - 20:29, 9 May 2024
LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
64 KB (7,058 words) - 14:51, 14 May 2024
subfamily "PTHR24352:SF30" for AKT1. GO molecular function: This tell you what are the functions of your query gene; e.g. AKT1 has protein kinase activity...
21 KB (2,612 words) - 20:49, 10 March 2024
symbol for the gene v-akt murine thymoma viral oncogene homolog 1, which is AKT1, cannot be said to be an acronym for the name, and neither can any of its...
36 KB (4,143 words) - 17:22, 24 May 2024
spontaneous apoptosis (AKT1), severe diabetes (AKT2), small brains (AKT3), and growth deficiency (AKT1/AKT2). Mice heterozygous for AKT1 have increased lifespan...
119 KB (12,654 words) - 16:07, 28 May 2024
mutations in the PIK3CA gene and 2 had tumor cells with mutations in the AKT1 gene. The mutations occurred in these genes' hot spots, i.e. areas of a genes'...
17 KB (2,023 words) - 16:51, 23 February 2024
both proteins in the dimer. BRAF (gene) has been shown to interact with: AKT1, C-Raf, HRAS, and YWHAB. GRCh38: Ensembl release 89: ENSG00000157764 – Ensembl...
49 KB (5,394 words) - 20:02, 23 April 2024
present in about one-fourth of meningiomas. Mutations in the TRAF7, KLF4, AKT1, and SMO genes are commonly expressed in benign skull-base meningiomas. Mutations...
41 KB (4,201 words) - 07:23, 5 April 2024
sclerosis complex 2 (TSC2) - Akt1 destabilises the Rho GTPase, inhibits F-actin assembly and reduces cell migration Palladin - Akt1 phosphorylates the actin-binding...
37 KB (4,116 words) - 06:54, 21 May 2024
LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
45 KB (4,670 words) - 00:07, 2 June 2024
LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
46 KB (5,509 words) - 06:42, 23 May 2024
dysregulation of the PI3K pathway via PI3KCA/PI3KCB mutations (6% of tumors) or AKT1 (2% of tumors). Prostate cancer is the second-most frequently diagnosed cancer...
76 KB (8,852 words) - 17:03, 27 May 2024
LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
14 KB (1,385 words) - 10:32, 28 April 2024
LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
14 KB (1,626 words) - 20:50, 30 May 2024
LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
17 KB (1,819 words) - 16:52, 22 May 2024
involved with the uptake of K+, then between 10 and 200μM both HAK5 and AKT1 are involved with the uptake of K+. HAK5 is coupled with CBL9/CIPK23 kinase's...
20 KB (2,308 words) - 06:16, 13 May 2024
LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
27 KB (2,665 words) - 17:03, 6 April 2024