• Thumbnail for AKT1
    serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases...
    24 KB (2,850 words) - 04:05, 29 September 2022
  • Thumbnail for Protein kinase B
    to PKB alpha and Akt1 alone.[citation needed] Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce...
    34 KB (3,754 words) - 20:14, 23 April 2024
  • Thumbnail for Proteus syndrome
    for the disorder, Lindhurst et al. identified an activating mutation in AKT1 kinase in a mosaic state. Previous research had suggested the condition linked...
    18 KB (1,926 words) - 15:43, 19 May 2024
  • Thumbnail for Granulosa cell tumour
    set of transcription factors perturbed by AKT1 activation. These results incriminate somatic mutations of AKT1 as probable driver events in the pathogenesis...
    12 KB (1,249 words) - 19:55, 3 December 2023
  • Thumbnail for Capivasertib
    2-negative locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN-alterations, as detected by an FDA-approved test, following progression...
    10 KB (608 words) - 22:53, 17 May 2024
  • and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP...
    12 KB (1,431 words) - 17:47, 28 October 2022
  • Thumbnail for PI3K/AKT/mTOR pathway
    isozymes, Akt1, Akt2 and Akt3. Small-molecule inhibitors of Akt1 could be especially useful to target tumors with a high prevalence of Akt1 E17K activating...
    36 KB (4,322 words) - 16:42, 6 October 2023
  • Thumbnail for GAB2
    GAB2 (section AKT1)
    GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. GAB2 is a docking protein with a conserved...
    26 KB (3,189 words) - 21:28, 2 December 2023
  • Thumbnail for Ovarian cancer
    in ovarian cancer subtypes Gene mutated Mutation type Subtype Prevalence AKT1 amplification 3% AKT2 amplification/mutation 6%, 20% ARID1A point mutation...
    194 KB (20,745 words) - 23:11, 15 May 2024
  • ÄKT), a Finnish music organization Karat (airline) (ICAO: AKT), in Russia AKT1, AKT2, or AKT3, enzymes Erich Akt (1898–?), German politician Akolet language...
    1 KB (180 words) - 08:25, 13 February 2022
  • Thumbnail for Claes Bang
    L'histoire du soldat The Devil/Narrator Copenhagen Phil 2015 Danske Permafrost AKT1 Danmarks Lydteater Live in the Dome of Visions, Copenhagen The Evil Erik...
    36 KB (2,054 words) - 11:13, 7 June 2024
  • Thumbnail for Homeobox
    COX-2, respectively. HoxA5 also upregulates the tumor suppressor p53 and Akt1 by downregulation of PTEN. Suppression of HoxA5 has been shown to attenuate...
    42 KB (4,469 words) - 17:00, 1 April 2024
  • Thumbnail for MK-2206
    highly selective inhibitor of pan-Akt, namely, of all three Akt isoforms Akt1, Akt2, and Akt3. It is intended to be used with other cancer therapies that...
    5 KB (376 words) - 06:37, 13 March 2023
  • Thumbnail for Resveratrol
    resveratrol had been identified, including NQO2 (alone and in interaction with AKT1), GSTP1, estrogen receptor beta, CBR1, and integrin αVβ. It was unclear at...
    40 KB (3,847 words) - 20:29, 9 May 2024
  • Thumbnail for AMP-activated protein kinase
    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
    64 KB (7,058 words) - 14:51, 14 May 2024
  • subfamily "PTHR24352:SF30" for AKT1. GO molecular function: This tell you what are the functions of your query gene; e.g. AKT1 has protein kinase activity...
    21 KB (2,612 words) - 20:49, 10 March 2024
  • symbol for the gene v-akt murine thymoma viral oncogene homolog 1, which is AKT1, cannot be said to be an acronym for the name, and neither can any of its...
    36 KB (4,143 words) - 17:22, 24 May 2024
  • Thumbnail for MTOR
    spontaneous apoptosis (AKT1), severe diabetes (AKT2), small brains (AKT3), and growth deficiency (AKT1/AKT2). Mice heterozygous for AKT1 have increased lifespan...
    119 KB (12,654 words) - 16:07, 28 May 2024
  • mutations in the PIK3CA gene and 2 had tumor cells with mutations in the AKT1 gene. The mutations occurred in these genes' hot spots, i.e. areas of a genes'...
    17 KB (2,023 words) - 16:51, 23 February 2024
  • Thumbnail for BRAF (gene)
    both proteins in the dimer. BRAF (gene) has been shown to interact with: AKT1, C-Raf, HRAS, and YWHAB. GRCh38: Ensembl release 89: ENSG00000157764 – Ensembl...
    49 KB (5,394 words) - 20:02, 23 April 2024
  • Thumbnail for Meningioma
    present in about one-fourth of meningiomas. Mutations in the TRAF7, KLF4, AKT1, and SMO genes are commonly expressed in benign skull-base meningiomas. Mutations...
    41 KB (4,201 words) - 07:23, 5 April 2024
  • sclerosis complex 2 (TSC2) - Akt1 destabilises the Rho GTPase, inhibits F-actin assembly and reduces cell migration Palladin - Akt1 phosphorylates the actin-binding...
    37 KB (4,116 words) - 06:54, 21 May 2024
  • Thumbnail for Titin
    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
    45 KB (4,670 words) - 00:07, 2 June 2024
  • LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
    46 KB (5,509 words) - 06:42, 23 May 2024
  • Thumbnail for Prostate cancer
    dysregulation of the PI3K pathway via PI3KCA/PI3KCB mutations (6% of tumors) or AKT1 (2% of tumors). Prostate cancer is the second-most frequently diagnosed cancer...
    76 KB (8,852 words) - 17:03, 27 May 2024
  • LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
    14 KB (1,385 words) - 10:32, 28 April 2024
  • Thumbnail for C-Jun N-terminal kinases
    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
    14 KB (1,626 words) - 20:50, 30 May 2024
  • Thumbnail for Glycogen synthase kinase-3 beta
    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
    17 KB (1,819 words) - 16:52, 22 May 2024
  • Thumbnail for High Affinity K+ transporter HAK5
    involved with the uptake of K+, then between 10 and 200μM both HAK5 and AKT1 are involved with the uptake of K+. HAK5 is coupled with CBL9/CIPK23 kinase's...
    20 KB (2,308 words) - 06:16, 13 May 2024
  • Thumbnail for Protein kinase A
    LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3...
    27 KB (2,665 words) - 17:03, 6 April 2024