mitochondrial is an enzyme that in humans is encoded by the ALDH2 gene located on chromosome 12. ALDH2 belongs to the aldehyde dehydrogenase family of enzymes...

"Asian flush" or "Asian glow". Around 30–50% of East Asians carry the rs671 (ALDH2*2) allele on chromosome 12, which results in a less functional acetaldehyde...

In all three classes, constitutive and inducible forms exist. ALDH1 and ALDH2 are the most important enzymes for aldehyde oxidation, and both are tetrameric...

there are three known genes which encode this enzymatic activity, ALDH1A1, ALDH2, and the more recently discovered ALDH1B1 (also known as ALDH5). These enzymes...

investigated in native Japanese who have a variant ALDH2 allele termed glu487lys, ALDH2*2 or ALDH2*504lys, which is a single nucleotide polymorphism allele...

ALDH2*2, and ALDH2*504lys. In the overall Japanese population, about 57% of individuals are homozygous for the normal allele (sometimes termed ALDH2*1)...

vessels. Individuals that have the ALDH2*2 allele, a variant that has a mutation when compared to the wild-type ALDH2 isozyme, are known to have higher...

another allele responsible for the flush reaction, the rs671 (ALDH2*2) of the ALDH2 is rare among Europeans and Sub-Saharan Black Africans, while 30%...

human ALDH2. Alda-1 has been proposed as a potential treatment for the alcohol flush reaction experienced by people with genetically deficient ALDH2. Ethanol...

conversion was only discovered to be mitochondrial aldehyde dehydrogenase (ALDH2) in 2002. Nitroglycerin is available in sublingual tablets, sprays, ointments...

is performed by aldehyde dehydrogenase (ALDH) enzymes. A mutation in the ALDH2 gene that encodes for an inactive or dysfunctional form of this enzyme affects...

now operating in the opposite direction. Many East Asian people have an ALDH2 mutation which makes them significantly less efficient at oxidizing acetaldehyde...

acetate mainly by aldehyde dehydrogenase (ALDH). ALDH2 is an isozyme of ALDH and ALDH2 has a polymorphism (ALDH2*2, Glu487Lys) that makes ADLH2 inactive; this...

original (PDF) on March 27, 2011. Eng, MY; Luczak, SE; Wall, TL (2007). "ALDH2, ADH1B, and ADH1C genotypes: A literature review". Alcohol Research & Health...

Sinica found that genes in alcohol metabolism pathway, especially ADH1B and ALDH2, conferred the major genetic risk for alcohol dependence in Taiwanese Han...

useful, but the root being likely harmful, as the latter is an inhibitor of ALDH2. Artichoke: Research shows that artichoke extract does not prevent the signs...

Griseofulvin (weak evidence) Hydrazines Isoniazid: causes headache via a non-ALDH2 mechanism Procarbazine Ketoconazole (weak evidence) Macrolide immunosuppressants...

in genes that encode the main enzymes of alcohol metabolism, ADH1B and ALDH2. These genetic factors influence the rate at which alcohol and its initial...

metabolizes ethanol to acetaldehyde too quickly for further processing by ALDH2 and thereby leads to the accumulation of acetaldehyde and rhinitis symptoms...

is catabolized by alcohol dehydrogenase ADH5 and aldehyde dehydrogenase ALDH2. Formaldehyde is a building block in the synthesis of many other compounds...

Facial flushing. Before (left) and after (right) drinking alcohol. A 22-year-old East Asian man who is ALDH2 heterozygous showing the reaction....

transformation from acetaldehyde to acetic acid is aldehyde dehydrogenase 2 family (ALDH2, EC 1.2.1.3). In humans, the gene coding for this enzyme is found on chromosome...

in the metabolism of ethanol. It has been shown that a mutation in the ALDH2 gene (one of 19 aldehyde dehydrogenase genes) is what leads to the common...

dendritic cell 2 unknown unknown thoracic thymus None None unknown None ALDH2, CD1C, CLEC10A, CTSH, GSN, HLA-DQA1, HAL-DQB1, JAML, LGALS2, MNDA cortical...

Increased activity of the mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2) has been shown to have a protective effect against cardiac ischemia in...

both enzymes may play a role. Several other enzymes, including MAO-B and ALDH2, further process the immediate metabolites of histamine for excretion or...

effect of APOE on Alzheimer's disease, and CHRNA5 on smoking behaviour, and ALDH2 (in individuals of East Asian ancestry) on alcohol use. On the other hand...

descent. According to the analysis by HapMap Project, the rs671 allele of the ALDH2 gene responsible for the flush reaction is rare among Europeans and Africans...

Miyamori; et al. (2015). "Tracing Jomon and Yayoi ancestries in Japan using ALDH2 and JC virus genotype distributions". Investigative Genetics. 6 (14): 14...

reduced electrophoretic DNA migration in peripheral blood leukocytes from ALDH2-deficient male Japanese?". Mutagenesis. 24 (4): 303–8. doi:10.1093/mutage/gep008...