• Thumbnail for Adenylyl cyclase
    Adenylate cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylyl cyclase, abbreviated AC) is an enzyme with systematic name ATP diphosphate-lyase...
    23 KB (2,568 words) - 14:08, 17 April 2024
  • Soluble adenylyl cyclase (sAC) is a regulatory cytosolic enzyme present in almost every cell. sAC is a source of cyclic adenosine 3’,5’ monophosphate (cAMP)...
    16 KB (1,834 words) - 16:41, 14 September 2023
  • of molecular biology, the cAMP-dependent pathway, also known as the adenylyl cyclase pathway, is a G protein-coupled receptor-triggered signaling cascade...
    11 KB (1,386 words) - 01:44, 28 March 2024
  • Thumbnail for Photoactivated adenylyl cyclase
    Photoactivated adenylyl cyclase (PAC) is a protein consisting of an adenylyl cyclase enzyme domain directly linked to a BLUF (blue light receptor using...
    10 KB (987 words) - 03:51, 29 November 2023
  • Thumbnail for Pituitary adenylate cyclase-activating peptide
    S2CID 5739004. Waschek JA (2002). "Multiple actions of pituitary adenylyl cyclase activating peptide in nervous system development and regeneration"...
    15 KB (1,728 words) - 20:37, 8 April 2024
  • Thumbnail for Guanylate cyclase
    and stimulating cone photoreceptor death. Adenylyl cyclase Cyclic guanosine monophosphate Guanylyl cyclase activator (protein) Martin, Emil; Berka, Vladimir;...
    12 KB (1,414 words) - 11:49, 27 February 2024
  • Thumbnail for Gs alpha subunit
    protein Gs that stimulates the cAMP-dependent pathway by activating adenylyl cyclase. Gsα is a GTPase that functions as a cellular signaling protein. Gsα...
    7 KB (782 words) - 01:11, 25 October 2023
  • Thumbnail for GNAS complex locus
    subunit Gs-α, a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways. GNAS stands for Guanine Nucleotide binding...
    14 KB (1,688 words) - 12:12, 21 December 2023
  • reaction to form a cyclic compound. Important cyclase enzymes include: Adenylyl cyclase, which forms cyclic AMP from adenosine triphosphate (EC 4.6.1.1) ADCY1...
    885 bytes (123 words) - 13:49, 23 September 2019
  • Thumbnail for Neurofibromatosis
    of adenylyl cyclase and its activity. Adenylyl cyclase plays an essential role in cognition. Neurofibromin's role in the activity of adenylyl cyclase explains...
    25 KB (2,366 words) - 09:02, 19 April 2024
  • Thumbnail for Forskolin
    study and research of cell physiology. Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP. cAMP is an important second...
    10 KB (907 words) - 09:13, 14 January 2024
  • Thumbnail for Oogenesis
    The cyclic AMP is generated by the oocyte by adenylyl cyclase in the oocyte membrane. The adenylyl cyclase is kept active by a constitutively active G-protein-coupled...
    30 KB (3,472 words) - 14:19, 16 April 2024
  • Thumbnail for Alfred G. Gilman
    on the cell surface. Cyclic AMP is formed from ATP by the enzymes adenylyl cyclase. In 1970 Martin Rodbell found that hormones did not directly influence...
    35 KB (3,668 words) - 11:39, 8 April 2024
  • Thumbnail for Glucagon
    separates from Gβ𝛾 and interacts with the transmembrane protein adenylyl cyclase. Adenylyl cyclase catalyzes the conversion of ATP to cAMP. cAMP binds to protein...
    24 KB (2,820 words) - 02:59, 22 November 2023
  • dissociates from the G protein, and associates with adenylyl cyclase. This causes the inactivation of adenylyl cyclase, resulting in a decrease of cAMP produced...
    25 KB (2,226 words) - 23:08, 28 April 2024
  • Thumbnail for ADCY5
    Adenylyl cyclase type 5 is an enzyme that in humans is encoded by the ADCY5 gene. ADCY5 has been shown to interact with RGS2. Mutations in ADCY5 are known...
    8 KB (997 words) - 14:15, 24 January 2024
  • Thumbnail for HA-tag
    IA, Lerner RA, Wigler M (1988). "Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition...
    3 KB (398 words) - 20:22, 19 October 2023
  • Thumbnail for ADCY6
    Adenylyl cyclase type 6 is an enzyme that in humans is encoded by the ADCY6 gene. This gene encodes adenylyl cyclase 6, which is a membrane-associated...
    7 KB (926 words) - 11:06, 1 August 2023
  • Thumbnail for Serotonin
    Signalling via Gαs activation of adenylyl cyclase. 5-HT5A 251.2 Memory consolidation. Signals via Gi/o inhibition of adenylyl cyclase. 5-HT6 98.41 Cognition (antagonists...
    127 KB (13,724 words) - 11:37, 24 March 2024
  • Thumbnail for Bithionol
    flukes). Bithionol has been shown to be a potent inhibitor of soluble adenylyl cyclase, an intracellular enzyme important in the catalysis of adenosine triphosphate...
    7 KB (660 words) - 22:16, 7 January 2024
  • Thumbnail for Somatostatin
    Inhibiting the release of thyroid-stimulating hormone (TSH) Inhibiting adenylyl cyclase in parietal cells Inhibiting the release of prolactin (PRL) Somatostatin...
    23 KB (2,566 words) - 00:09, 5 April 2024
  • proteins primarily inhibit the cAMP dependent pathway by inhibiting adenylyl cyclase activity, decreasing the production of cAMP from ATP, which, in turn...
    12 KB (931 words) - 18:23, 14 August 2023
  • Thumbnail for Melanocortin 1 receptor
    It is coupled to Gαs and upregulates levels of cAMP by activating adenylyl cyclase in cells expressing this receptor. It is normally expressed in skin...
    33 KB (3,753 words) - 12:46, 21 April 2024
  • Thumbnail for GABA receptor agonist
    receptor belongs to the class of G-Protein coupled receptors that inhibit adenylyl cyclase, therefore leading to decreased cyclic adenosine monophosphate (cAMP)...
    8 KB (740 words) - 19:39, 11 March 2024
  • are inhibited with an antagonist, ethanol consumption is reduced. Adenylyl cyclase (AC) plays a role in ethanol induced signaling pathways. Acute ethanol...
    48 KB (6,687 words) - 08:04, 21 September 2023
  • Thumbnail for Beta-adrenergic agonist
    increase the breakdown of lipids in obese patients. β1 agonists stimulate adenylyl cyclase activity and opening of calcium channel (cardiac stimulants; used to...
    9 KB (798 words) - 00:24, 30 December 2022
  • Thumbnail for Cyclic nucleotide
    nucleotidyl cyclases, such that production of cAMP is catalyzed by adenylyl cyclase and production of cGMP is catalyzed by guanylyl cyclase. Adenylyl cyclase has...
    21 KB (2,416 words) - 10:27, 3 December 2023
  • Thumbnail for Mushroom bodies
    synergistic increase in cAMP is mediated by and dependent on rutabaga adenylyl cyclase (rut AC), which is sensitive to both calcium (which results from voltage-gated...
    29 KB (3,400 words) - 23:32, 26 April 2024
  • Thumbnail for Heterotrimeric G protein
    inhibit adenylyl cyclase. The alpha subunit of a stimulatory G protein activated by receptors for stimulatory hormones could stimulate adenylyl cyclase, which...
    13 KB (1,237 words) - 18:10, 26 April 2024
  • Thumbnail for Dopamine receptor
    protein Gsα. D1 is also coupled to Golf. Gsα subsequently activates adenylyl cyclase, increasing the intracellular concentration of the second messenger...
    50 KB (5,328 words) - 21:14, 21 April 2024