• Thumbnail for Alpha-actinin-2
    Alpha-actinin-2 is a protein which in humans is encoded by the ACTN2 gene. This gene encodes an alpha-actinin isoform that is expressed in both skeletal...
    21 KB (2,601 words) - 17:21, 3 December 2023
  • Thumbnail for Alpha-actinin-3
    Alpha-actinin-3, also known as alpha-actinin skeletal muscle isoform 3 or F-actin cross-linking protein, is a protein that in humans is encoded by the...
    13 KB (1,559 words) - 14:02, 19 January 2024
  • coordinates contractions between sarcomeres in the horizontal axis. Alpha-actinin is a part of the spectrin superfamily. This superfamily is made of spectrin...
    13 KB (1,647 words) - 16:53, 29 November 2023
  • Thumbnail for Alpha-actinin-1
    Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse...
    12 KB (1,374 words) - 04:19, 8 March 2024
  • Thumbnail for Alpha-actinin-4
    Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse...
    12 KB (1,455 words) - 04:22, 8 March 2024
  • TRPP3 is abundant in mouse brain where it associates with alpha-actinin-2. Alpha-actinin attaches TRPP3 to the cytoskeleton and up-regulates its channel...
    11 KB (1,385 words) - 04:58, 3 September 2023
  • Thumbnail for LDB3
    targeting and clustering of membrane proteins. ZASP interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its...
    15 KB (1,591 words) - 05:43, 10 March 2024
  • Thumbnail for PDLIM3
    intercalated discs. ALP functions to enhance the crosslinking of actin by alpha-actinin-2 and also appears to be essential for right ventricular chamber formation...
    12 KB (1,420 words) - 01:33, 10 March 2024
  • Thumbnail for ADAM12
    muscle regeneration, to the muscle-specific actin-binding protein, alpha -actinin-2, is required for myoblast fusion". J. Biol. Chem. 275 (18): 13933–9...
    13 KB (1,579 words) - 07:19, 29 April 2024
  • Thumbnail for KCNA5
    interact with DLG4, PDZ domain-containing proteins such as SAP97, and Actinin, alpha 2. Voltage-gated potassium channel GRCh38: Ensembl release 89: ENSG00000130037...
    12 KB (1,460 words) - 21:07, 27 March 2024
  • Thumbnail for PDLIM1
    gene. PDLIM1 has been shown to interact with: Actinin alpha 4, Actinin, alpha 1, Estrogen receptor alpha, and RNF12. GRCh38: Ensembl release 89: ENSG00000107438...
    8 KB (1,069 words) - 11:40, 17 October 2022
  • Thumbnail for SYNPO2
    myopodin interacts with stress fibers prior to co-localizing with alpha actinin-2 at Z-discs in mature striated muscle cells. Myopodin has been shown...
    9 KB (1,055 words) - 23:25, 11 March 2024
  • Thumbnail for MYOT
    composed of 496 amino acids. Myotilin was originally identified as a novel alpha-actinin binding partner with two Ig-like domains, that localized to the Z-disc...
    17 KB (2,143 words) - 09:49, 10 March 2024
  • Thumbnail for Calcium/calmodulin-dependent protein kinase type II subunit alpha
    disability with growth retardation. CAMK2A has been shown to interact with: Actinin alpha 4, CDK5R1, and DLG1. GRCh38: Ensembl release 89: ENSG00000070808 – Ensembl...
    13 KB (1,466 words) - 02:09, 3 December 2023
  • Thumbnail for Zyxin
    that encode the same isoform. Zyxin has been shown to interact with: Actinin, alpha 1 ENAH, LASP1, LATS1, and Vasodilator-stimulated phosphoprotein. ENSG00000285443...
    11 KB (1,262 words) - 19:59, 23 December 2023
  • Thumbnail for LRRC7
    Laboratory. Identified interaction partners include: CaMKII-alpha, alpha-Actinin and NR2B (via CaMKII-alpha), Cav1.3 (L-type Ca2+) channels, MAGUIN-1, Shank, PSD-95...
    8 KB (1,106 words) - 20:34, 3 March 2023
  • Thumbnail for TRIM3
    TRIM3 has been shown to interact with Actinin alpha 4. TRIM3 binds to and ubiquitinates Estrogen receptor alpha (ERa) leading to receptor's stabilization...
    5 KB (678 words) - 01:22, 29 November 2023
  • Thumbnail for SORBS2
    muscle cells, pull-down experiments discovered ArgBP2 in complex with alpha actinin-2, vinculin, spectrin, paxillin, Pyk2 and flotillin, suggesting that...
    17 KB (2,094 words) - 12:16, 4 January 2024
  • Thumbnail for Integrin beta 1
    interaction between alpha-actinin and the beta 1 integrin subunit in vitro". The Journal of Cell Biology. 111 (2): 721–9. doi:10.1083/jcb.111.2.721. PMC 2116186...
    22 KB (2,600 words) - 22:18, 2 April 2024
  • proteins or receptors named A1 or Alpha-1 : Actin, alpha 1 Actinin, alpha 1 Adaptor-related protein complex 2, alpha 1 Aldehyde dehydrogenase 3 family...
    5 KB (667 words) - 18:06, 14 March 2022
  • Thumbnail for Tropomyosin
    muscle fibers. These electron-dense rod bodies are composed mainly of α-actinin and actin. The disorder is often clinically categorized into several groups...
    51 KB (6,192 words) - 19:26, 10 May 2024
  • Thumbnail for CSRP3
    with proteins at the: Z-line, including telethonin (T-cap), alpha-actinin (ACTN), cofilin-2 (CFL2), calcineurin, HDAC4, MLP-b as well as to MLP itself;...
    33 KB (4,114 words) - 00:22, 30 December 2023
  • Thumbnail for CDK5R2
    CDK5R2 (category Genes on human chromosome 2)
    kinase-activating proteins. CDK5R2 has been shown to interact with Actinin, alpha 1. GRCh38: Ensembl release 89: ENSG00000171450 – Ensembl, May 2017 GRCm38:...
    5 KB (632 words) - 20:58, 3 March 2023
  • Thumbnail for Gene doping
    growth factor, fibroblast growth factor, endorphin, enkephalin and alpha-actinin-3. The risks of gene doping would be similar to those of gene therapy:...
    32 KB (3,911 words) - 00:09, 27 February 2024
  • Thumbnail for Adherens junction
    studies.[citation needed] Tight junction Pardo, JV, Craig, SW (1979). "alpha-Actinin localization in the junctional complex of intestinal epithelial cells"...
    5 KB (505 words) - 05:55, 18 April 2024
  • Thumbnail for Sarcomere
    titin molecules are cross-linked in the Z-disc via the Z-line protein alpha-actinin. The M-band proteins myomesin as well as C-protein crosslink the thick...
    12 KB (1,553 words) - 21:43, 10 March 2024
  • Thumbnail for KCNA4
    and Kv1.4 potassium channels interacts with the spectrin repeats of alpha-actinin-2". FEBS Letters. 498 (1): 87–92. doi:10.1016/S0014-5793(01)02505-4....
    14 KB (1,787 words) - 21:07, 27 March 2024
  • Thumbnail for Smooth muscle
    Z-discs in striated muscle sarcomeres. Dense bodies are rich in alpha-actinin (α-actinin), and also attach intermediate filaments (consisting largely of...
    37 KB (4,704 words) - 11:19, 9 April 2024
  • Thumbnail for MYOZ2
    alpha-actinin at Z-discs, and inhibit the pathological cardiac hypertrophic response. This differs from the fast-skeletal muscle isoform, calsarcin-2...
    10 KB (1,255 words) - 22:36, 3 March 2023
  • Thumbnail for Α-Catenin
    Α-Catenin (redirect from Alpha-catenin)
    the actin binding proteins vinculin and α-actinin can bind to alpha-catenin. It has been suggested that alpha-catenin does not bind with high affinity...
    21 KB (2,888 words) - 11:43, 4 January 2024