Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the...

condensation in late anaphase, to help chromosome segregation and the re-formation of the nucleus. Anaphase starts when the anaphase promoting complex marks an inhibitory...

Maturation-promoting factor (abbreviated MPF, also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin–Cdk complex that was discovered...

activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/CCdc20...

with the anaphase-promoting complex, SCF has important roles in the ubiquitination of proteins involved in the cell cycle. The SCF complex also marks...

triggers the abrupt shift to anaphase. This abrupt shift is caused by the activation of the anaphase-promoting complex and its function of tagging degradation...

(cdc20 homolog 1) is one of the substrate adaptor proteins of the anaphase-promoting complex (APC) in the budding yeast Saccharomyces cerevisiae. Functioning...

equatorial line. The protein complex cohesin holds sister chromatids together from the time of their replication until anaphase. In mitosis, the force of...

progression to anaphase. Any unattached or improperly attached kinetochores generate signals that prevent the activation of the anaphase promoting complex (cyclosome...

the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation". Genes & Development. 12 (12):...

Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene. A large protein complex, termed the anaphase-promoting...

cohesin complex which links the sister chromatids together. Without Cdc20, the anaphase-promoting complex (APC) cannot become activated and anaphase is not...

of this checkpoint is the stimulation of the anaphase-promoting complex by M-phase cyclin-CDK complexes, which in turn causes the proteolytic destruction...

of anaphase, securin is dephosphorylated by Cdc14 and other phosphatases. Dephosphorylated securin is recognized by the Anaphase-Promoting Complex (APC)...

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene. The anaphase-promoting complex (APC) consists of at least...

transcription factors downregulate expression of S phase cyclin genes; anaphase-promoting complex (APC) is activated, which targets and degrades S and M cyclins...

assembly checkpoint inhibits the anaphase promoting complex. Normally, activation of the anaphase promoting complex leads to the separation of sister...

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene. Multiple transcript variants encoding different isoforms...

anaphase-promoting complex". Gene. 262 (1–2): 51–9. doi:10.1016/S0378-1119(00)00511-4. PMID 11179667. "Entrez Gene: ANAPC1 anaphase promoting complex...

(or APC2), part of the Anaphase-promoting complex. CUL1, 2, 3, 4A, 4B, 5 and 7 each form part of a multi-subunit ubiquitin complex. Cullin-RING ubiquitin...

Geminin levels drop at the metaphase-anaphase transition of mitosis when it is degraded by the anaphase-promoting complex. During S phase, geminin is a negative...

cyclin. Cyclins are targeted for proteolytic degradation by the anaphase promoting complex (APC), also known as the cyclosome, a ubiquitin-ligase. The active...

Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene. ANAPC11 has been shown to interact with ANAPC2 and CDC27...

Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene. A large protein complex, termed the anaphase-promoting...

Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene. ANAPC10 has been shown to interact with CDC27, Mothers...

signal. This prevents premature progression into anaphase by inhibiting the anaphase-promoting complex until all kinetochores are attached and all the...

of anaphase-promoting complex (APC). This controls the rate of production of cyclin, and regulates cyclin levels and controls the S-phase-promoting factor...

checkpoint complex (MCC). Thereby it inhibits the activity of the anaphase-promoting complex/cyclosome (APC/C). Homologues of Mad1 are conserved in eukaryotes...

checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events". The Journal...

S-phase and is degraded at the metaphase-anaphase transition, possibly through ubiquination by anaphase promoting complex (APC). Various cell cycle checkpoints...