• Thumbnail for Antithrombin
    Antithrombin (AT) is a small glycoprotein that inactivates several enzymes of the coagulation system. It is a 464-amino-acid protein produced by the liver...
    45 KB (5,331 words) - 23:48, 9 March 2024
  • Antithrombin III deficiency (abbreviated ATIII deficiency) is a deficiency of antithrombin III. This deficiency may be inherited or acquired. It is a rare...
    5 KB (474 words) - 23:41, 27 November 2023
  • Thrombin–antithrombin complex (TAT) is a protein complex of thrombin and antithrombin. It is a marker of net activation of coagulation. TAT is formed in...
    6 KB (648 words) - 03:34, 13 August 2023
  • Thumbnail for Coagulation
    levels of FVIII, also may lead to a thrombotic tendency.[citation needed] Antithrombin is a serine protease inhibitor (serpin) that degrades the serine proteases:...
    61 KB (5,960 words) - 15:41, 29 April 2024
  • Thumbnail for Anticoagulant
    approves Antithrombin as an anticoagulant for preventing clots before, during, or after surgery or birthing in patients with hereditary antithrombin deficiency...
    78 KB (8,726 words) - 15:18, 29 April 2024
  • and in vitro studies have demonstrated that protamine neutralizes the antithrombin activity of LMWHs, normalizing the aPTT and thrombin time. However, protamine...
    27 KB (3,061 words) - 15:16, 29 April 2024
  • Thumbnail for Fondaparinux
    direct factor Xa inhibitors, it mediates its effects indirectly through antithrombin III, but unlike heparin, it is selective for factor Xa. Fondaparinux...
    9 KB (711 words) - 10:19, 16 August 2023
  • Thumbnail for ATryn
    ATryn is the brand name of the anticoagulant antithrombin manufactured by the Massachusetts-based U.S. company rEVO Biologics (formerly known as GTC Biotherapeutics)...
    6 KB (521 words) - 21:10, 27 April 2023
  • Thumbnail for Fresh frozen plasma
    and rechecking laboratory values. Use in antithrombin III deficiency: FFP can be used as a source of antithrombin III in patients who are deficient of this...
    17 KB (1,769 words) - 09:45, 14 January 2024
  • Thumbnail for Thrombin
    the coagulation cascade. In human adults, the normal blood level of antithrombin activity has been measured to be around 1.1 units/mL. Newborn levels...
    26 KB (2,946 words) - 11:32, 24 March 2024
  • the Antithrombin molecules in neonates and children is larger than in adults. Antithrombin: the levels of antithrombin increase with age. Antithrombin levels...
    9 KB (1,184 words) - 13:48, 7 June 2022
  • Thumbnail for Thrombophilia
    first major form of thrombophilia to be identified by medical science, antithrombin deficiency, was identified in 1965, while the most common abnormalities...
    43 KB (5,067 words) - 17:24, 19 January 2024
  • Thumbnail for Serpin
    reported in the late 1800s, but it was not until the 1950s that the serpins antithrombin and alpha 1-antitrypsin were isolated, with the subsequent recognition...
    136 KB (14,251 words) - 15:12, 4 May 2024
  • Thumbnail for Heparin
    glycosaminoglycan. Heparin is a blood anticoagulant that increases the activity of antithrombin. It is used in the treatment of heart attacks and unstable angina. It...
    77 KB (7,861 words) - 06:21, 9 April 2024
  • Thumbnail for Hirudin
    principal inhibitor of thrombin in normal blood circulation is antithrombin. Similar to antithrombin, the anticoagulant activity of hirudin is based on its ability...
    7 KB (822 words) - 18:17, 11 April 2024
  • "Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational...
    25 KB (3,112 words) - 19:03, 28 February 2024
  • Thumbnail for CSL Limited
    Rhophylac (Rh(D) immunoglobulin G) Tetanus Immunoglobulin-VF Thrombotrol-VF (antithrombin III) Vivaglobin, sub-cutaneous human immune globulin indicated for the...
    30 KB (2,888 words) - 09:54, 3 March 2024
  • transaccional (Spanish for "transactional analysis"), a psychological method Antithrombin, a small protein molecule Ataxia–telangiectasia, an immunodeficiency...
    3 KB (434 words) - 01:47, 4 May 2024
  • Thumbnail for Protease
    excessive protease-triggered activation of its own complement system), antithrombin (which protects the body from excessive coagulation), plasminogen activator...
    26 KB (2,799 words) - 22:42, 25 April 2024
  • Thumbnail for Thrombus
    cascade. Heparin works by binding to and activating the enzyme inhibitor antithrombin III, an enzyme that acts by inactivating thrombin and factor Xa. In contrast...
    21 KB (2,280 words) - 19:04, 6 March 2024
  • Thumbnail for Enoxaparin sodium
    bleeding and neurological changes. Enoxaparin binds to and potentiates antithrombin (a circulating anticoagulant) to form a complex that irreversibly inactivates...
    22 KB (1,670 words) - 03:50, 31 March 2024
  • Thumbnail for Deep vein thrombosis
    VTE rates. Genetic factors include non-O blood type, deficiencies of antithrombin, protein C, and protein S and the mutations of factor V Leiden and prothrombin...
    144 KB (14,621 words) - 23:44, 23 January 2024
  • Human immunoglobulin for anti-tetanus use and antithrombin produced by Grifols....
    11 KB (940 words) - 15:22, 3 April 2024
  • Thumbnail for Virchow's triad
    Leiden mutation, coagulation factor II G2021A mutation, deficiency of antithrombin III, protein C or S deficiency, nephrotic syndrome, changes after severe...
    10 KB (707 words) - 12:59, 20 December 2023
  • transaminase ASX asymptomatic A-T ataxia-telangiectasia AT antithrombin angiotensin AT-III antithrombin III ATA antitransglutaminase antibodies ATB antibiotic...
    18 KB (4 words) - 21:02, 23 April 2024
  • lead to mutations through intrastrand and interstrand switching. The antithrombin III gene's coding region is an example of an imperfect inverted repeat...
    31 KB (3,443 words) - 04:34, 25 October 2023
  • Thumbnail for Fibrinogen
    reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting. Fibrin also mediates blood platelet and endothelial...
    37 KB (3,907 words) - 03:37, 23 November 2023
  • Thumbnail for Estrogen
    Increase circulating level of factors 2, 7, 9, 10, plasminogen Decrease antithrombin III Increase platelet adhesiveness Increase vWF (estrogen -> Angiotensin...
    72 KB (7,575 words) - 07:57, 13 April 2024
  • Thumbnail for Liver
    VII, VIII, IX, X, XI, XII, XIII, as well as protein C, protein S and antithrombin. The liver is a major site of production for thrombopoietin, a glycoprotein...
    85 KB (10,183 words) - 16:46, 1 May 2024
  • Thumbnail for Dalteparin sodium
    stroke or heart attack. Dalteparin acts by potentiating the activity of antithrombin III, inhibiting formation of both Factor Xa and thrombin. It is normally...
    6 KB (483 words) - 19:31, 5 January 2024