 | Cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme (EC 3.1.4.17) from the phosphodiesterase class. It is found in various tissues... 15 KB (1,824 words) - 02:11, 20 December 2023 |
 | by cAMP or cGMP by inhibition of their degradation by PDE. Sildenafil (Viagra) is an inhibitor of cGMP-specific phosphodiesterase type 5, which enhances... 14 KB (1,660 words) - 17:53, 12 February 2024 |
Type 5 To-Ku, an amphibious tank CGMP specific phosphodiesterase type 5 Hyper IgM Syndrome Type 5 PDE5 inhibitor, a vasodilator drug Peugeot Type 5 Dietrich-Bugatti... 972 bytes (160 words) - 13:59, 1 January 2024 |
 | PDE5 inhibitor (redirect from Phosphodiesterase V inhibitors) A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase... 16 KB (1,721 words) - 14:51, 11 March 2024 |
| (84% in humans), is another cGMP-specific phosphodiesterase inhibitor which inhibits PDE9, a cGMP preferring phosphodiesterase. PDE9 is expressed as high... 22 KB (2,348 words) - 07:30, 22 April 2024 |
 | (March 1997). "Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)". The Journal of Biological Chemistry. 272 (11): 6823–6... 17 KB (1,898 words) - 05:39, 29 August 2023 |
 | blood pressure. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis... 70 KB (6,742 words) - 14:09, 3 May 2024 |
dysfunction. One treatment for erectile dysfunction is cGMP-specific phosphodiesterase type 5 inhibitors, which enable patients to resume having sex despite... 22 KB (2,241 words) - 18:09, 11 February 2024 |
 | The US FDA approved sildenafil, a selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5), for the treatment of PAH in 2005. It is marketed... 89 KB (8,891 words) - 00:01, 1 May 2024 |
(EC 3.1.4.3) CGMP specific phosphodiesterase type 5 (EC 3.1.4.17) Phospholipase D (EC 3.1.4.50) Category:EC 3.1.21 Restriction enzyme Type 1 (EC 3.1.21... 33 KB (3,650 words) - 10:58, 5 May 2024 |
many types of molecules, including nucleotides, proteins, and alkaloids. Phosphodiesterase (PDE), inactivates the second messenger cAMP cGMP specific phosphodiesterase... 3 KB (293 words) - 18:49, 27 October 2023 |
 | Cyclic adenosine monophosphate (redirect from 3',5'-Cyclic adenylic acid) monophosphate (cGMP) 8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) Acrasin specific to chemotactic use in Dictyostelium discoideum. phosphodiesterase 4 (PDE... 16 KB (1,612 words) - 17:03, 22 January 2024 |
 | α-subunit activates cGMP phosphodiesterase. cGMP phosphodiesterase breaks down cGMP, an intracellular second messenger which opens cGMP-gated cation channels... 17 KB (1,991 words) - 19:50, 1 May 2024 |
 | signal is terminated when cGMP is broken down by the enzyme cGMP specific phosphodiesterase type 5 (PDE5), the enzyme that is targeted by sildenafil and other... 3 KB (345 words) - 17:20, 4 March 2024 |
 | Cyclic guanosine monophosphate (redirect from Cyclic guanosine 3'-5' monophosphate) Numerous cyclic nucleotide phosphodiesterases (PDE) can degrade cGMP by hydrolyzing cGMP into 5'-GMP. PDE 5, -6 and -9 are cGMP-specific while PDE1, -2, -3,... 11 KB (1,122 words) - 01:24, 20 February 2024 |
monophosphate (cGMP) which leads to several biological processes like effect on intracellular calcium level by the Ca2+ pathway. Phosphodiesterase 5 (PDE5) is... 42 KB (4,750 words) - 00:42, 24 August 2023 |
 | protecting cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum, allowing for... 29 KB (2,754 words) - 21:05, 23 January 2024 |
 | tone, insulin secretion, and peristalsis. Once formed, cGMP can be degraded by phosphodiesterases, which themselves are under different forms of regulation... 12 KB (1,414 words) - 11:49, 27 February 2024 |
 | rights within the United States. Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme found in various body tissues, primarily in the corpus... 8 KB (518 words) - 22:24, 7 January 2024 |
PDE1 (redirect from 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I) isoforms exhibit different affinities for cAMP and cGMP. The existence of the Ca2+-stimulated Phosphodiesterase 1 was first demonstrated by Cheung (1970), Kakiuchi... 22 KB (2,560 words) - 15:24, 27 September 2023 |
 | for impotence, which inhibits cGMP specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP, which is produced by guanylate... 6 KB (577 words) - 11:31, 17 January 2024 |
 | citation needed] The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP.[medical citation needed] Tadalafil... 36 KB (3,238 words) - 06:08, 28 March 2024 |
 | different substrate specificities. Some are cAMP selective hydrolases (PDE 4, -7 and -8), others are cGMP selective hydrolases (PDE 5, -6 and -9) and the... 25 KB (2,872 words) - 02:43, 7 March 2023 |
 | The enzyme PDE-5, found in the corpus cavernosum smooth muscle, is responsible for degrading cyclic guanosine monophosphate (cGMP) to 5-GMP. Inhibitors... 31 KB (3,350 words) - 00:44, 8 December 2023 |
 | transducin then activates the enzyme cGMP-specific phosphodiesterase (PDE). PDE then catalyzes the hydrolysis of cGMP to 5' GMP. This is the second amplification... 26 KB (2,933 words) - 10:12, 9 February 2024 |
bound GTP to GDP, and thus halts the action of phosphodiesterase, stopping the transformation of cGMP to GMP. This deactivation step of the phototransduction... 20 KB (2,366 words) - 13:12, 12 April 2024 |
 | Cyclic nucleotide–gated ion channel (redirect from CGMP-gated cation channel) activation of the enzyme phosphodiesterase, which hydrolyzes cGMP into 5’-GMP, decreasing the concentration of cGMP. In the absence of cGMP, the CNG channels... 39 KB (4,913 words) - 23:11, 11 January 2024 |
 | domain is named after some of the proteins it is found in: cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. The first structure of a GAF domain... 3 KB (364 words) - 04:52, 30 August 2021 |
 | The lab discovered that inhibiting phosphodiesterase type 5A(PDE5A), which degraded cyclic guanosine onophosphate (cGMP) and was inhibited by the drug sildenafil... 17 KB (2,176 words) - 15:25, 6 March 2024 |
 | Enzyme inhibitor (section Types) sildenafil (Viagra). This compound is a potent inhibitor of cGMP specific phosphodiesterase type 5, the enzyme that degrades the signalling molecule cyclic... 104 KB (11,575 words) - 10:05, 2 March 2024 |