• Thumbnail for Catenin beta-1
    Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. β-Catenin is a dual function protein...
    107 KB (12,345 words) - 09:19, 30 April 2024
  • Thumbnail for Α-Catenin
    alpha-catenin. It has been suggested that alpha-catenin does not bind with high affinity to both actin filaments and the E-cadherin-beta-catenin complex...
    21 KB (2,888 words) - 11:43, 4 January 2024
  • Thumbnail for Adenomatous polyposis coli
    the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell...
    28 KB (3,225 words) - 01:48, 6 May 2024
  • Thumbnail for Catenin alpha-1
    αE-catenin, also known as Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. αE-catenin is highly expressed in cardiac muscle and...
    23 KB (2,782 words) - 21:55, 15 April 2024
  • Thumbnail for Dishevelled binding antagonist of beta catenin 1
    Dishevelled binding antagonist of beta catenin 1 (Dact1, previously known as Dapper, Dpr1, Frodo) is a protein that in humans is encoded by the DACT1 gene...
    9 KB (964 words) - 20:48, 3 December 2023
  • δ-Catenin is a subfamily of catenin proteins with ten armadillo-repeats and includes the proteins catenin delta-1 and catenin delta-2. Catenin delta-2...
    3 KB (359 words) - 00:44, 26 September 2023
  • Thumbnail for Glycogen synthase kinase-3 beta
    N, Dell'Oro A, et al. (September 2000). "Hot spots in beta-catenin for interactions with LEF-1, conductin and APC". Nature Structural Biology. 7 (9):...
    16 KB (1,777 words) - 09:28, 31 March 2024
  • Thumbnail for P120 catenin
    p120 catenin, or simply p120, also called catenin delta-1, is a protein that in humans is encoded by the CTNND1 gene. This gene encodes a member of the...
    18 KB (2,053 words) - 02:39, 16 April 2024
  • Thumbnail for Catenin
    became known as α-catenin and β-catenin. α-Catenin can bind to β-catenin and can also bind filamentous actin (F-actin). β-Catenin binds directly to the...
    29 KB (3,565 words) - 18:16, 8 May 2024
  • the protein beta-catenin (β-catenin) while a noncanonical pathway operates independently of it. The canonical Wnt pathway (or Wnt/β-catenin pathway) is...
    63 KB (7,427 words) - 04:01, 10 March 2024
  • Thumbnail for Lymphoid enhancer-binding factor 1
    target. Lymphoid enhancer-binding factor 1 has been shown to interact with: ALX4, AML-1, Catenin beta-1/β-catenin/CTNNB1, including transgenically, EP300...
    15 KB (1,797 words) - 07:24, 15 January 2024
  • Thumbnail for Plakoglobin
    Plakoglobin (redirect from Gamma catenin)
    gamma-catenin, is a protein that in humans is encoded by the JUP gene. Plakoglobin is a member of the catenin protein family and homologous to β-catenin. Plakoglobin...
    40 KB (4,695 words) - 21:17, 8 April 2024
  • mutations the adenomatous polyposis coli (APC), AXIN2, or rarely the beta-catenin genes. Wharton KA Jr, Zimmermann G, Rousset R, Scott MP. Vertebrate proteins...
    3 KB (359 words) - 18:30, 8 October 2023
  • Thumbnail for Cadherin-1
    region is vital to beta-catenin binding and, therefore, to E-cadherin function. Beta-catenin can also bind to alpha-catenin. Alpha-catenin participates in...
    55 KB (6,434 words) - 22:24, 2 May 2024
  • Thumbnail for CTNNBIP1
    CTNNBIP1 (category Genes on human chromosome 1)
    Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene. The protein encoded by this gene binds CTNNB1 and prevents...
    8 KB (973 words) - 03:26, 3 December 2023
  • Thumbnail for Presenilin-1
    Presenilin 1 has been shown to form a complex with beta-catenin, an important component in Wnt signaling, and stabilize beta-catenin. Mutant of presenilin-1 that...
    25 KB (3,113 words) - 11:23, 31 December 2023
  • Thumbnail for Zebrafish
    and Catenin beta-1/β-catenin/CTNNB1. Dorsky et al. 2002 investigated the developmental role of Wnt by transgenically expressing a Lef1/β-catenin reporter...
    106 KB (11,535 words) - 09:33, 25 April 2024
  • Thumbnail for Protein chibby homolog 1
    Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene. Beta-catenin is a transcriptional activator and oncoprotein involved...
    6 KB (836 words) - 10:56, 7 September 2023
  • Thumbnail for AXIN2
    presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat...
    11 KB (1,422 words) - 12:33, 24 December 2023
  • Thumbnail for AXIN1
    interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein) beta 1, glycogen synthase kinase 3 beta, protein phosphatase 2, and itself....
    17 KB (2,157 words) - 03:32, 9 May 2024
  • Thumbnail for BCL9
    BCL9 (category Genes on human chromosome 1)
    2), have been extensively studied for their role as transcriptional beta-catenin cofactors, fundamental for the transcription of Wnt target genes. Recent...
    11 KB (1,269 words) - 14:59, 26 January 2024
  • Thumbnail for Hepatoblastoma
    polyps and adenocarcinoma, frequently develop hepatoblastomas. Also, beta-catenin mutations have been shown to be common in sporadic hepatoblastomas, occurring...
    11 KB (1,031 words) - 16:42, 1 January 2023
  • Thumbnail for BTRC (gene)
    survival. βTrCP also associates with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional...
    28 KB (3,356 words) - 01:22, 22 March 2024
  • Thumbnail for DKK1
    DKK1 (redirect from Dkk-1)
    J, Reguart N, et al. (October 2004). "Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma". Biochemical and Biophysical...
    16 KB (1,959 words) - 10:25, 28 March 2024
  • Thumbnail for TCF/LEF family
    of the beta-catenin protein, which as a consequence translocated into the cell nucleus. However, since the protein structure of beta-catenin did not...
    17 KB (2,038 words) - 15:13, 11 December 2023
  • DisProt home page features examples of DisProt entries, i.e. p53 and Catenin beta-1, along with entries of proteins belonging to the SARS-CoV-2 virus, e...
    10 KB (948 words) - 13:37, 22 July 2023
  • Thumbnail for LRP6
    "Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades". Cancer Biol. Ther. 5 (9): 1059–64. doi:10...
    11 KB (1,411 words) - 12:13, 4 April 2024
  • Thumbnail for Hans Clevers
    cancer where the APC gene is doubly mutated, TCF family members activate catenin beta-1, which then enhances the expression of many genes that cause cancer...
    43 KB (3,314 words) - 00:00, 29 March 2024
  • Thumbnail for Dishevelled
    integral part of the Wnt canonical pathway (β-catenin dependent) and non-canonical pathway (β-catenin-independent). In either of these, DVL acts downstream...
    12 KB (1,374 words) - 15:08, 1 August 2023
  • Beta-keratin (β-keratin) is a member of a structural protein family found in the epidermis of reptiles and birds. Beta-keratins were named so because they...
    7 KB (847 words) - 14:56, 24 April 2024