• Thumbnail for Cholesterol side-chain cleavage enzyme
    Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage. P450scc is a mitochondrial...
    24 KB (2,657 words) - 13:17, 24 January 2024
  • Thumbnail for Steroidogenic enzyme
    present in other tissues in the body. Steroid desmolases Cholesterol side-chain cleavage enzyme (20,22-desmolase) – steroid synthesis 17,20-Lyase (17,20-desmolase)...
    6 KB (504 words) - 03:45, 23 November 2023
  • Thumbnail for Spironolactone
    Spironolactone (category Cholesterol side-chain cleavage enzyme inhibitors)
    weakly inhibit a broad array of steroidogenic enzymes including cholesterol side-chain cleavage enzyme, 17α-hydroxylase, 17,20-lyase, 5α-reductase, 3β-hydroxysteroid...
    186 KB (18,252 words) - 21:52, 1 April 2024
  • Thumbnail for Ketoconazole
    Ketoconazole (category Cholesterol side-chain cleavage enzyme inhibitors)
    Specifically, ketoconazole has been shown to inhibit cholesterol side-chain cleavage enzyme, which converts cholesterol to pregnenolone, 17α-hydroxylase and 17,20-lyase...
    50 KB (4,369 words) - 10:03, 6 April 2024
  • Thumbnail for Danazol
    Danazol (category Cholesterol side-chain cleavage enzyme inhibitors)
    varying extents, of a variety of steroidogenic enzymes, including cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase...
    46 KB (3,954 words) - 04:46, 8 April 2024
  • Thumbnail for Lipoid congenital adrenal hyperplasia
    22-desmolase, but now identified as cytochrome P450scc (cholesterol side chain cleavage enzyme). However, few cases of lipoid CAH due to a mutation and...
    20 KB (2,367 words) - 10:40, 5 March 2024
  • Thumbnail for Aminoglutethimide
    Aminoglutethimide (category Cholesterol side-chain cleavage enzyme inhibitors)
    enzymes such as cholesterol side-chain cleavage enzyme (CYP11A1, P450scc) and aromatase (CYP19A1), thereby inhibiting the conversion of cholesterol into...
    32 KB (2,828 words) - 01:55, 30 November 2023
  • Desmolase (category Enzymes)
    Examples of desmolases are: Cholesterol side-chain cleavage enzyme, also called 20,22-desmolase; converts cholesterol to pregnenolone. 17,20-Desmolase...
    1 KB (148 words) - 17:32, 15 August 2023
  • Thumbnail for Leydig cell
    pregnenolone formation from the translocated cholesterol via the cholesterol side-chain cleavage enzyme, which is found in the inner mitochondrial membrane...
    10 KB (1,037 words) - 12:01, 21 March 2024
  • toxicity caused by accumulation of desmosterol in tissues. Cholesterol side-chain cleavage enzyme (P450scc, CYP11A1) inhibitors such as aminoglutethimide...
    37 KB (2,107 words) - 11:12, 27 September 2022
  • Thumbnail for HPTE
    HPTE (category Cholesterol side-chain cleavage enzyme inhibitors)
    disruptor which has estrogenic activity, and also inhibits Cholesterol side-chain cleavage enzyme (P450scc, CYP11A1) and 3α-hydroxysteroid dehydrogenase (3α-HSD)...
    4 KB (254 words) - 00:17, 9 January 2023
  • Thumbnail for 22R-Hydroxycholesterol
    steroid hormones from cholesterol. Cholesterol ((3β)-cholest-5-en-3-ol) is hydroxylated by cholesterol side-chain cleavage enzyme (P450scc) to form...
    3 KB (186 words) - 16:33, 26 April 2023
  • Thumbnail for Inner mitochondrial membrane
    F-ATPase ATP–ADP translocase ATP-binding cassette transporter Cholesterol side-chain cleavage enzyme Protein tyrosine phosphatase Carnitine O-palmitoyltransferase...
    8 KB (908 words) - 22:54, 15 February 2024
  • Thumbnail for Levoketoconazole
    Levoketoconazole (category Cholesterol side-chain cleavage enzyme inhibitors)
    Levoketoconazole has also been found to inhibit CYP11A1 (cholesterol side-chain cleavage enzyme) and CYP51A1 (lanosterol-14α-demethylase), similarly but...
    8 KB (432 words) - 11:08, 3 December 2023
  • Thumbnail for Menstrual cycle
    normal menstrual cycles. In the corpus luteum, cholesterol side-chain cleavage enzyme converts cholesterol to pregnenolone, which is converted to progesterone...
    52 KB (6,259 words) - 18:41, 29 April 2024
  • Thumbnail for Mitotane
    Mitotane (category Cholesterol side-chain cleavage enzyme inhibitors)
    inhibitor of the adrenal cortex. It acts as an inhibitor of cholesterol side-chain cleavage enzyme (P450scc, CYP11A1), and also of 11β-hydroxylase (CYP11B1)...
    11 KB (813 words) - 04:40, 3 April 2024
  • Thumbnail for 20α,22R-Dihydroxycholesterol
    steroid hormones from cholesterol. Cholesterol ((3β)-cholest-5-en-3-ol) is hydroxylated by cholesterol side-chain cleavage enzyme (P450scc) to form...
    3 KB (177 words) - 05:24, 8 May 2023
  • cytochrome P450 modulators, or inhibitors and inducers of cytochrome P450 enzymes. In alphabetical order. List of steroid metabolism modulators Includes...
    9 KB (78 words) - 09:09, 12 November 2023
  • Thumbnail for Canrenone
    Canrenone (category Cholesterol side-chain cleavage enzyme inhibitors)
    spironolactone, canrenone inhibits steroidogenic enzymes such as 11β-hydroxylase, cholesterol side-chain cleavage enzyme, 17α-hydroxylase, 17,20-lyase, and 21-hydroxylase...
    14 KB (1,084 words) - 20:41, 17 December 2023
  • Thumbnail for Etomidate
    Etomidate (category Cholesterol side-chain cleavage enzyme inhibitors)
    synthesis in the adrenal cortex by reversibly inhibiting 11β-hydroxylase, an enzyme important in adrenal steroid production; it leads to primary adrenal suppression...
    31 KB (3,311 words) - 17:56, 21 March 2024
  • testosterone Cholesterol side-chain cleavage enzyme inhibitors (P450SCC/CYP11A1 inhibitors): inhibit the synthesis of pregnenolone from cholesterol, thereby...
    3 KB (266 words) - 18:40, 1 December 2023
  • Thumbnail for Trilostane
    Trilostane (category Cholesterol side-chain cleavage enzyme inhibitors)
    intended for breeding Side effects of trilostane in conjunction with a corticosteroid in humans include gastrointestinal side effects like gastritis...
    24 KB (1,897 words) - 03:30, 20 March 2024
  • estrogens Cholesterol side-chain cleavage enzyme inhibitors (P450SCC/CYP11A1 inhibitors): inhibit the synthesis of pregnenolone from cholesterol, thereby...
    2 KB (183 words) - 11:06, 27 September 2022
  • Thumbnail for Congenital adrenal hyperplasia
    Congenital adrenal hyperplasia (category Cholesterol and steroid metabolism disorders)
    CYP17A1 (17α-hydroxylase/17,20-lyase), CYP11A1 (P450scc; cholesterol side-chain cleavage enzyme), STAR (steroidogenic acute regulatory protein; StAR), CYB5A...
    43 KB (4,403 words) - 15:41, 30 March 2024
  • Thumbnail for Testosterone
    cholesterol . The first step in the biosynthesis involves the oxidative cleavage of the side-chain of cholesterol by cholesterol side-chain cleavage enzyme...
    149 KB (15,647 words) - 18:10, 15 April 2024
  • include: Cholesterol side-chain cleavage enzyme inhibitors (P450SCC/CYP11A1 inhibitors): inhibit the synthesis of pregnenolone from cholesterol, thereby...
    2 KB (186 words) - 11:06, 27 September 2022
  • Thumbnail for Dehydroepiandrosterone
    produced in the brain. DHEA is synthesized from cholesterol via the enzymes cholesterol side-chain cleavage enzyme (CYP11A1; P450scc) and 17α-hydroxylase/17...
    42 KB (3,935 words) - 13:26, 25 April 2024
  • Thumbnail for Cholesterol
    cholesterol contributes to the fluidity of the cell membrane, as the molecule is in a trans conformation making all but the side chain of cholesterol...
    79 KB (8,518 words) - 20:19, 27 April 2024
  • deficiency, 3β-hydroxysteroid dehydrogenase deficiency, and cholesterol side-chain cleavage enzyme or steroidogenic acute regulatory protein deficiency) and...
    25 KB (2,798 words) - 17:49, 30 August 2023
  • Thumbnail for Enzyme
    substrate interacts with the enzyme. As a result, the substrate does not simply bind to a rigid active site; the amino acid side-chains that make up the active...
    96 KB (9,774 words) - 02:03, 3 April 2024