along its 5' → 3' direction. CpG sites occur with high frequency in genomic regions called CpG islands. Cytosines in CpG dinucleotides can be methylated...

methylated CpG site (a cytosine followed by guanine along its 5' → 3' direction and where the cytosine is methylated (5-mCpG)). A 5-mCpG site has the lowest...

occurs on the cytosine nucleotide in a CpG site, in plants the cytosine can be methylated at CpG, CpHpG, and CpHpH sites, where H represents any nucleotide...

CpG may refer to: CpG site - methylated sequences of DNA significant in gene regulation CpG island - regions of DNA that contain several CpG sites CpG...

CpG site). In mammals, DNA methyltransferases (which add methyl groups to DNA bases) exhibit a strong sequence preference for cytosines at CpG sites....

(CpG sites). In the mouse brain, 4.2% of all cytosines are methylated, primarily in the context of CpG sites, forming 5mCpG. Most hypermethylated 5mCpG...

methylated CpG site (a cytosine followed by guanine along its 5' → 3' direction and where the cytosine is methylated (5-mCpG)). A 5-mCpG site has the lowest...

transcription start site of a gene (proximal promoters) contain a CpG island. CpG islands are generally 200 to 2000 base pairs long, have a C:G base pair content...

differentially methylated CpG sites returned to the level of never-smokers within five years of smoking cessation. However, 2,568 CpGs among 942 genes remained...

along its 5' → 3' direction (at CpG sites). This forms a 5mCpG site. More than 98% of DNA methylation occurs at CpG sites in mammalian somatic cells. Thus...

mammalian brain, ~62% of CpGs are methylated. Methylation of CpG sites tends to stably silence genes. More than 500 of these CpG sites are de-methylated in...

diabetes. In a normal cell, the bulk genome is highly methylated at CpGs, whereas CpG islands (CPI) at gene promoter regions remain highly unmethylated...

a demethylation pathway shown in the second figure. The thousands of CpG sites being demethylated during memory formation depend on ROS in an initial...

majority of gene promoters contain a CpG island with numerous CpG sites. When many of a gene's promoter CpG sites are methylated the gene becomes inhibited...

occurs in the DNA sequence CpG, changing the DNA at the CpG site from CpG to 5-mCpG. Methylation of cytosines in CpG sites in promoter regions of genes...

guanine, a CpG site. The number of CpG sites in the human genome is about 28 million. Depending on the type of cell, about 70% of the CpG sites have a methylated...

Verbascoside) Calorically perfect gas Clopidogrel CpG ODN, a synthetic TLR9 agonist CpG site, a site in DNA CpG island, a specialized region of DNA Central...

of CpG dinucleotides (CpG sites), forming 5-methylcytosine (5mC). Thus, a CpG site may be methylated to form 5mCpG. The presence of 5mC at CpG sites in...

at a CpG site, which is a cytosine followed by a guanine. The “p” refers to the phosphate linker between them. DMR usually involves adjacent sites or a...

(G) within CpG sites. This is an important repair function since about 1/3 of all intragenic single base pair mutations in human cancers occur in CpG dinucleotides...

mammalian brain, ~62% of CpGs are methylated. Methylation of CpG sites tends to stably silence genes. More than 500 of these CpG sites are de-methylated in...

or 5-mCpG). Methylated cytosines within CpG sequences often occur in groups, called CpG islands. About 59% of promoter sequences have a CpG island while...

mouse sperm genome is 80–90% methylated at its CpG sites in DNA, amounting to about 20 million methylated sites.[citation needed] After fertilization, the...

difference (cytosine versus thymine) to measure methylation at a specific CpG site. The human disease sickle cell anemia is caused by a genetic mutation in...

sequence, a CpG site.) Methylation of CpG sites in a promoter region of a gene usually represses gene transcription, while methylation of CpGs in the body...

MECP2 (methyl CpG binding protein 2) is a gene that encodes the protein MECP2. MECP2 appears to be essential for the normal function of nerve cells. The...

the nervous system. This disruption leads to an elevation in methylated CpG sites, causing DNA hypermethylation. The mutations can either occur due to new...

DNA methylation dysregulation is the promoter hypermethylation where the CPGs islands in the promoter regions are methylated contributing or causing genes...

repressor. cosmid cpDNA See chloroplast DNA. CpG island A region of a genome in which CpG sites occur repetitively or with high frequency. CpG site A sequence...

methylation. DNA methylation of a CpG island in a promoter region may cause silencing of its downstream gene (see CpG site and regulation of transcription...