 | Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as an electron donor, which can be... 40 KB (4,581 words) - 23:34, 26 January 2024 |
 | A dihydrofolate reductase inhibitor (DHFR inhibitor) is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate.... 4 KB (406 words) - 05:06, 3 December 2023 |
 | acid is a form of folic acid that does not require activation by dihydrofolate reductase to be useful to the body. Folinic acid was first made in 1945.... 17 KB (1,511 words) - 19:25, 17 March 2024 |
Dihydrofolate reductase deficiency (DHFR deficiency) is a rare inherited disorder of folate metabolism caused by defects in the DHFR gene. The disorder... 2 KB (261 words) - 14:25, 22 January 2023 |
 | Trimethoprim (category Bacterial dihydrofolate reductase inhibitors) animals but not humans. It works by blocking folate metabolism via dihydrofolate reductase in some bacteria, preventing creation of bacterial DNA and RNA... 18 KB (1,411 words) - 18:25, 13 April 2024 |
 | Dihydrofolic acid (redirect from Dihydrofolate) (conjugate base dihydrofolate) (DHF) is a folic acid (vitamin B9) derivative which is converted to tetrahydrofolic acid by dihydrofolate reductase. Since tetrahydrofolate... 3 KB (165 words) - 15:31, 5 June 2022 |
 | (PABA) in the biosynthesis of dihydrofolate. Trimethoprim serves as a competitive inhibitor of dihydrofolate reductase (DHFR), hence inhibiting the de... 48 KB (4,040 words) - 21:53, 12 May 2024 |
 | and two products. When enzymes bind multiple substrates, such as dihydrofolate reductase (shown right), enzyme kinetics can also show the sequence in which... 71 KB (9,346 words) - 13:26, 1 February 2024 |
 | include two amine groups on a pyrimidine ring. They include many dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and piritrexim... 1 KB (116 words) - 03:34, 23 October 2022 |
 | that acts as a powerful folate metabolism inhibitor by inhibiting dihydrofolate reductase, with hypoxanthine (a purine derivative) and thymidine (a deoxynucleoside)... 5 KB (638 words) - 02:17, 12 May 2024 |
 | 1970s with ethyl methanesulfonate to generate a cell line lacking dihydrofolate reductase (DHFR) activity, referred to as CHO-DXB11 (also referred to as... 16 KB (1,927 words) - 02:37, 1 February 2024 |
 | steps both catalyzed by the same enzyme, dihydrofolate reductase. Folic acid is first reduced to dihydrofolate and then to tetrahydrofolate. Each step... 100 KB (10,942 words) - 21:58, 9 May 2024 |
 | Cycloguanil is a dihydrofolate reductase inhibitor, and is a metabolite of the antimalarial drug proguanil; its formation in vivo has been thought to... 6 KB (517 words) - 22:12, 7 January 2024 |
 | competes with dihydrofolate at the binding site of dihydrofolate reductase (DHFR). The binding of Hydroxy-H2PteGlu to dihydrofolate reductase will block... 20 KB (1,801 words) - 16:44, 29 April 2024 |
 | substrate of dihydrofolate reductase, an enzyme that is potently inhibited by methotrexate. Methotrexate blocks the action of dihydrofolate reductase and thereby... 104 KB (11,575 words) - 10:05, 2 March 2024 |
 | derivative. Tetrahydrofolic acid is produced from dihydrofolic acid by dihydrofolate reductase. This reaction is inhibited by methotrexate. It is converted into... 7 KB (447 words) - 23:07, 4 November 2023 |
 | Methotrexate, a chemotherapeutic, acts as a competitive inhibitor at the dihydrofolate reductase active site. This interaction inhibits the synthesis of tetrahydrofolate... 27 KB (3,035 words) - 18:48, 4 November 2023 |
 | potent inhibitors of the enzymes enoyl-acyl carrier protein reductase, and dihydrofolate reductase. Since many oxidoreductases use NAD+ and NADH as substrates... 79 KB (8,992 words) - 04:22, 15 April 2024 |
 | Trimetrexate (category Mammalian dihydrofolate reductase inhibitors) Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor. It has been used with leucovorin in treating pneumocystis pneumonia... 4 KB (200 words) - 23:10, 1 April 2023 |
 | sometimes mixed with the drug trimethoprim, which acts against dihydrofolate reductase. As of 2013, the Republic of Ireland is the largest exporter worldwide... 18 KB (1,856 words) - 10:52, 21 November 2023 |
 | "Modulation of methylenetetrahydrofolate reductase activity by S-adenosylmethionine and by dihydrofolate and its polyglutamate analogues" (PDF). Advances... 34 KB (3,737 words) - 07:12, 15 April 2024 |
 | production of deoxyribonucleotides via inhibition of the enzyme ribonucleotide reductase by scavenging tyrosyl free radicals as they are involved in the reduction... 19 KB (1,767 words) - 04:36, 20 March 2024 |
the function of mitochondria in malaria while proguanil blocks dihydrofolate reductase. Atovaquone/proguanil was approved for medical use in the United... 12 KB (1,039 words) - 10:41, 4 March 2024 |
 | Gleisner, J. M.; Blakley, R. L. (2 December 1975). "Bovine liver dihydrofolate reductase: purification and properties of the enzyme". Biochemistry. 14 (24):... 34 KB (3,635 words) - 04:45, 2 April 2024 |
 | Methotrexate (category Mammalian dihydrofolate reductase inhibitors) different pathways. For cancer, methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis... 34 KB (3,112 words) - 09:16, 21 April 2024 |
 | though at least one study have shown slow and variable activity of dihydrofolate reductase in human liver. A diet rich in natural folate (350 μg/d) can show... 50 KB (5,814 words) - 16:48, 29 April 2024 |
 | drug known for use in cancer treatment, inhibits or shuts down dihydrofolate reductase (DHFR) pre-mRNA processing and/or nuclear mRNA stability in... 23 KB (3,023 words) - 12:36, 22 February 2024 |
 | Exposing cells to aminopterin (a folic acid analogue which inhibits dihydrofolate reductase) makes them unable to use the de novo pathway and become fully... 47 KB (4,794 words) - 19:52, 5 May 2024 |
Trimethoprim/polymyxin (category Bacterial dihydrofolate reductase inhibitors) The drug combination trimethoprim/polymyxin (INNs, trade name Polytrim) is an antimicrobial solution for topical ophthalmic use in the treatment of acute... 2 KB (45 words) - 20:40, 29 January 2023 |
 | synthetic form of folate, and must undergo enzymatic reduction by dihydrofolate reductase (DHFR) to become biologically active. It is synthesized in the... 14 KB (1,115 words) - 10:55, 22 April 2024 |