The dopamine transporter (DAT, also sodium-dependent dopamine transporter) is a membrane-spanning protein coded for in the human by the SLC6A3 gene (also...
37 KB (4,635 words) - 06:51, 29 March 2024
by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dopamine not absorbed by the postsynaptic...
15 KB (1,568 words) - 05:51, 29 April 2024
neurotransmitters norepinephrine and dopamine by blocking the action of the norepinephrine transporter (NET) and the dopamine transporter (DAT), respectively. This...
6 KB (418 words) - 18:16, 10 October 2023
mediated either by the dopamine transporter or by the plasma membrane monoamine transporter. Once back in the cytosol, dopamine can either be broken down...
138 KB (14,161 words) - 05:06, 22 May 2024
sodium/chloride-dependent family of neurotransmitter transporters, including dopamine, epinephrine, serotonin and GABA transporters. A single-nucleotide polymorphism (SNP)...
31 KB (3,397 words) - 02:14, 21 December 2023
transport proteins for monoamines (i.e., the dopamine transporter, norepinephrine transporter, and serotonin transporter) in monoamine neurons. Other SLC18A2...
17 KB (2,015 words) - 05:34, 27 November 2023
and dopamine by blocking the actions of the serotonin transporter (SERT) and dopamine transporter (DAT), respectively. This in turn leads to increased...
16 KB (1,821 words) - 01:24, 30 March 2024
three major classes are serotonin transporters (SERTs), dopamine transporters (DATs), and norepinephrine transporters (NETs) and are responsible for the...
21 KB (2,342 words) - 01:36, 18 May 2024
Dopaminergic (category Dopamine)
facilitate dopamine-related activity. For example, certain proteins such as the dopamine transporter (DAT), vesicular monoamine transporter 2 (VMAT2),...
11 KB (1,161 words) - 01:41, 13 May 2024
binding site overlapping the substrate binding site. The Drosophila dopamine transporter, which displays a pharmacology similar to SERT, was crystallized...
30 KB (3,578 words) - 00:39, 27 December 2023
Dopamine transporter deficiency syndrome (DTDS), also known as infantile parkinsonism-dystonia, is a rare movement disorder that causes progressively worsening...
12 KB (1,211 words) - 17:47, 9 May 2024
Cocaine (category Serotonin–norepinephrine–dopamine reuptake inhibitors)
blocks the dopamine transporter, inhibiting reuptake of dopamine from the synaptic cleft into the pre-synaptic axon terminal; the higher dopamine levels in...
162 KB (17,679 words) - 05:13, 20 May 2024
and dopamine. It does this by concomitantly inhibiting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT)...
126 KB (15,216 words) - 22:05, 5 April 2024
uptake of dopamine (DA) by blocking dopamine transporters (DAT). The dopamine transporter controls the dynamics of the neurotransmitter dopamine. This neurotransmitter...
15 KB (1,530 words) - 22:09, 1 February 2024
been associated with Rage syndrome. A genetic polymorphism in the dopamine transporter gene has been linked to Rage syndrome, and dogs at risk of passing...
29 KB (3,114 words) - 07:11, 19 May 2024
monoamine transporters, with pure SSRIs having strong affinity for the serotonin transporter and only weak affinity for the norepinephrine and dopamine transporters...
127 KB (13,843 words) - 23:34, 28 April 2024
Adderall (category Norepinephrine-dopamine releasing agents)
membrane-bound monoamine transporters (i.e., the dopamine transporter, norepinephrine transporter, or serotonin transporter) to either stop transporting...
56 KB (19,815 words) - 16:38, 1 May 2024
Mesolimbic pathway (redirect from Mesolimbic dopamine pathway)
synaptic dopamine through blocking the presynaptic dopamine transporter. Another stimulant, amphetamine, reverses the dopamine transporter and induces...
29 KB (3,487 words) - 18:05, 24 September 2023
be due to a ratio between the dopamine transporter and VMAT2. Based on the understanding the increased cytosolic dopamine levels lead to dopaminergic cell...
43 KB (4,993 words) - 22:10, 12 March 2024
Methylphenidate (category Norepinephrine–dopamine reuptake inhibitors)
monoamine transporters when they are co-administered.[better source needed] Methylphenidate has both dopamine transporter and norepinephrine transporter binding...
139 KB (12,681 words) - 05:37, 22 May 2024
Neurotransmitter (redirect from Dopamine system)
medication. Cocaine blocks a dopamine transporter responsible for the reuptake of dopamine. Without the transporter, dopamine diffuses much more slowly from...
94 KB (8,335 words) - 05:54, 5 May 2024
norepinephrine, and dopamine by blocking the action of one or more of the respective monoamine transporters (MATs), which include the serotonin transporter (SERT)...
19 KB (1,337 words) - 20:21, 22 December 2023
However, PCP has little affinity for the human monoamine transporters, including the dopamine transporter (DAT). Instead, its inhibition of monoamine reuptake...
56 KB (5,322 words) - 21:46, 11 May 2024
Methamphetamine (category Norepinephrine-dopamine releasing agents)
the transport direction of the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT). When methamphetamine binds...
150 KB (14,837 words) - 17:20, 16 May 2024
CE-123 (category Dopamine reuptake inhibitors)
"A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes". Neuropharmacology...
5 KB (415 words) - 04:32, 15 November 2023
Janelle M.; Furrow, Eva (3 June 2021). "Association analysis of dopamine transporter gene ( SLC6A3 ) variants with risk for seizures and aggression in...
20 KB (1,825 words) - 22:52, 25 April 2024
may show reduced dopamine transporter activity. A DLB diagnosis may be warranted if other conditions with reduced dopamine transporter uptake can be ruled...
136 KB (14,526 words) - 20:29, 19 April 2024
DaT scan (category Dopamine reuptake inhibitors)
DaT Scan (DaT scan or Dopamine Transporter Scan) commonly refers to a diagnostic method, based on SPECT imaging, to investigate if there is a loss of dopaminergic...
6 KB (556 words) - 11:44, 13 January 2024
(dopamine receptor-interacting proteins) interactions. The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine...
50 KB (5,328 words) - 21:14, 21 April 2024
Dextroamphetamine (category Norepinephrine-dopamine releasing agents)
or reverses the transporter proteins for the monoamine neurotransmitters (namely the serotonin, norepinephrine and dopamine transporters) either via trace...
59 KB (18,936 words) - 09:48, 9 May 2024