An enamine is an unsaturated compound derived by the condensation of an aldehyde or ketone with a secondary amine. Enamines are versatile intermediates...

The Stork enamine alkylation involves the addition of an enamine to a Michael acceptor (e.g., an α,β -unsaturated carbonyl compound) or another electrophilic...

pattern. Non-carbon nucleophiles such as water, alcohols, amines, and enamines can also react with an α,β-unsaturated carbonyl in a 1,4-addition. Some...

reactions. In 1963, G. Stork reported the first enamine alkylation reaction for ketones - Stork enamine alkylation reaction. In 1976, Meyers reported the...

ketone) initially forms a phenylhydrazone which isomerizes to the respective enamine (or 'ene-hydrazine'). After protonation, a cyclic [3,3]-sigmatropic rearrangement...

titanium tetrachloride. In the Stork enamine alkylation, secondary amines form enamines when exposed to ketones. These enamines then react (possibly enantio­selectively)...

aldehydes toward nucleophilic addition by formation of enamines (e.g. used in the Stork enamine alkylation): International Union of Pure and Applied Chemistry...

CH3), classified as an enamine. It is a colorless liquid. Primary and secondary enamines tend to isomerize, but tertiary enamines are kinetically stable...

Nitrogen Amine Enamine Ammonium Hydrazo Nitrene Imine Oxime Hydrazone Azo Amide Imidate Amidine Carbamate Imide Nitrile Isonitrile Cyanate Isocyanate...

isomerized to enamine 3 (94%). This enamine was then subjected to another isomerization, which yielded the more thermodynamically more stable enamine 4. NaIO4-oxidation...

ammonia or a primary amine gives an imine With secondary amine gives an enamine With Grignard and organolithium reagents to give, after aqueous workup...

Nitrogen Amine Enamine Ammonium Hydrazo Nitrene Imine Oxime Hydrazone Azo Amide Imidate Amidine Carbamate Imide Nitrile Isonitrile Cyanate Isocyanate...

electron delocalisation with the indole ring.[citation needed] LSD also has enamine-type reactivity because of the electron-donating effects of the indole...

is widely used to convert ketones to enamines. Enamines derived from piperidine are substrates in the Stork enamine alkylation reaction. Upon treatment...

the β carbon of the β-ketoesters (2), and eventually forming an enamine (3). The enamine then attacks the carbonyl carbon of the α-haloketone (4). This...

subsequent hydrolysis of the remaining aluminium and iron. Acetals, imines, and enamines can be converted back into ketones by treatment with excess water under...

and reduction by dihydroprecondylocarpine acetate synthase (DPAS), an enamine intermediate is formed. The intermediate undergoes fragmentation to produce...

from o-nitrotoluenes 1.[1][2][3] The first step is the formation of an enamine 2 using N,N-dimethylformamide dimethyl acetal and pyrrolidine.[4] The desired...

bonded are far more common. Isothiazones are produced by oxidation of enamine-thiones. The ring structure of isothiazole is incorporated into larger...

varying proportions. The active species is the hexafluoropropylamine; any enamine is converted into this by the hydrogen fluoride byproduct as the reaction...

R'_2CH-NHR}}} Similarly, secondary amines react with ketones and aldehydes to form enamines: R 2 NH + R ′ ( R ″ CH 2 ) C = O ⟶ R ″ CH = C ( NR 2 ) R ′ + H 2 O {\displaystyle...

the modern field of asymmetric organocatalysis. Researches on asymmetric enamine catalysis applied to important intermediates in steroids synthesis is due...

Nitrogen Amine Enamine Ammonium Hydrazo Nitrene Imine Oxime Hydrazone Azo Amide Imidate Amidine Carbamate Imide Nitrile Isonitrile Cyanate Isocyanate...

Betti reaction Kabachnik–Fields reaction Pictet–Spengler reaction Stork enamine alkylation Nitro-Mannich reaction Smith, Michael B.; March, Jerry (2007)...

Nitrogen Amine Enamine Ammonium Hydrazo Nitrene Imine Oxime Hydrazone Azo Amide Imidate Amidine Carbamate Imide Nitrile Isonitrile Cyanate Isocyanate...

treatment with trimethylsilylchloride in the presence of base. It forms an enamine with pyrrolidine. Treatment with nitrosyl chloride and ethanol in sulfur...

of proline in the transition state determine the reaction outcome. An enamine is formed during the reaction and only one proline molecule is involved...

Nitrogen Amine Enamine Ammonium Hydrazo Nitrene Imine Oxime Hydrazone Azo Amide Imidate Amidine Carbamate Imide Nitrile Isonitrile Cyanate Isocyanate...

reactions, and performed pioneering work on enamine chemistry, leading to development of the Stork enamine alkylation.: 111  It is believed he was responsible...

[3+3]cycloaddition between a cyclic enone and an enamine catalyzed by n-butyllithium is a Stork enamine / 1,2-addition cascade reaction: IronDiiminopyridine...