Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded...

Hemochromatosis type 4 is a hereditary iron overload disorder that affects ferroportin, an iron transport protein needed to export iron from cells into circulation...

low such as in hemochromatosis, iron overload occurs due to increased ferroportin mediated iron efflux from storage and increased gut iron absorption....

mammals, ferroportin. Hephaestin, a ferroxidase that can oxidize Fe2+ to Fe3+ and is found mainly in the small intestine, helps ferroportin transfer iron...

marrow by the transmembrane ferroportin transporter. In response to elevated plasma iron levels, hepcidin inhibits the ferroportin transporter leading to decreased...

African people carry a unique ferroportin mutation that predisposes them iron overload, making it a kind of ferroportin disease. African-Americans, who...

concentrations in excess of 5 μg Mn/m3 can lead to Mn-induced symptoms. Increased ferroportin protein expression in human embryonic kidney (HEK293) cells is associated...

and release from the liver. Hepcidin production and release shuts down ferroportin, a protein that controls export of iron from the gut and from iron storing...

mammals, ferroportin. Hephaestin, a ferroxidase that can oxidize Fe2+ to Fe3+ and is found mainly in the small intestine, helps ferroportin transfer iron...

for ferroportin, prove the rule: these people have plenty of hepcidin, but their cells lack the proper response to it. So, in people with ferroportin proteins...

iron efflux from ferroportin has come under scrutiny. One model suggests that APP acts to stabilize the iron efflux protein ferroportin in the plasma membrane...

inhibiting microbe iron uptake Hepcidin Stimulates the internalization of ferroportin, preventing release of iron bound by ferritin within intestinal enterocytes...

expression of hepcidin in the liver which targets the iron transporter ferroportin on the basolateral membrane of enterocytes and cell membrane of macrophages...

the enterocyte to Fe2+ ferroportin allows the passage of iron through the cell membrane for export. In the blood, ferroportin is then converted to transferrin...

stored internally in ferritin or is released into the circulation via ferroportin. In cases where systemic iron levels are raised, or where inflammation...

raising questions about efficacy of this form of treatment. Increased ferroportin protein expression in human embryonic kidney (HEK293) cells is associated...

gland Release GH from anterior pituitary 35 Hepcidin HAMP Peptide liver ferroportin inhibits iron export from cells 36 Human Chorionic Gonadotropin HCG Peptide...

blood cell production). Hepcidin binds to and induces the degradation of ferroportin, which is responsible for exporting iron from cells and mobilizing it...

Palis J, Fleming MD, Andrews NC, Zon LI. Positional cloning of zebrafish ferroportin 1 identifies a conserved vertebrate iron exporter. Nature 2000; 403:776-81...

investigators to the discovery of a gene polymorphism in the gene for ferroportin, which predisposes some people of African descent to iron overload. Secondary...

alleged criminal offence Federated portal network, a software architecture Ferroportin, a protein Filtered-popping network in computer science Fixed-pattern...

efflux most likely in cooperation with the basolateral iron transporter, ferroportin 1. To a lesser extent hephaestin has been detected in colon, spleen,...

Meta-Analysis". ASN-Online. 2020-10-22. Retrieved 2022-05-20. "Oral ferroportin inhibitor ameliorates ineffective erythropoiesis in a model of β-thalassemia"...

encode iron metabolism genes, including ferritin, transferrin receptor 1, ferroportin, HIF2 alpha, and several other transcripts. IRP1 acquires an iron-sulfur...

occur through a simpler channel-like mechanism. Solute carrier family Ferroportin Vastermark A, Wollwage S, Houle ME, Rio R, Saier MH (October 2014). "Expansion...

raising questions about efficacy of this form of treatment. Increased ferroportin protein expression in human embryonic kidney (HEK293) cells is associated...

hepcidin, ERFE increases the function of the cellular iron export channel, ferroportin. This then results in increased iron absorption from the intestine and...

(February 2004). "The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1)". Pflügers Archiv. 447 (5): 801–806. doi:10.1007/s00424-003-1102-3...

the cells that line the small intestine (enterocytes). From there, the ferroportin/IREG1 transporter exports it across the cell membrane where is it oxidized...

ACO2, Hao1, SLC11A2 (encoding DMT1), NDUFS1, SLC40A1 (encoding the ferroportin) CDC42BPA , CDC14A, EPAS1. In humans, 12 genes have been shown to be...