The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the...

prior to first dose, taking first dose at night (so avoiding falls, etc) and starting on low doses and titrating upwards. First pass effect Graham RM...

rapid absorption, avoidance of first-pass metabolism, sustained plasma concentrations, and a local endometrial effect, while advantages of intravaginal...

administration as well. In particular, the oral route is subject to a high first-pass effect, which results in high levels of testosterone in the liver and consequent...

high first-pass effect, which results in high levels of estradiol and consequent estrogenic effects in the liver and low potency due to first-pass hepatic...

fluid. ADME Partition coefficient Bioavailability Drug metabolism First pass effect Polar surface area IVIVC Mehta M (2016). Biopharmaceutics Classification...

the liver before reaching general circulation. This is known as the first pass effect. As a consequence, certain drugs can only be taken via certain routes...

producing complete abortion in a period of 24 hours due to the liver's first-pass effect which reduces the bioavailability of the misoprostol. Vaginal and...

the gut. It has a total bioavailability of 10% due to an extensive first-pass effect, or up to 40% if taken after a fatty meal. Highest blood plasma levels...

method of treatment, as vascular delivery suffers from a "pulmonary first pass effect" where intravenous injected cells are sequestered in the lungs. Further...

tranquillisers Ethanol (alcohol) Diazoxide Drugs subject to a strong first-pass effect such as beta blockers may increase the bioavailability of hydralazine...

administration(first pass effect is avoided and therefore no amount drug is lost). A drug must be lipophilic (lipid soluble) in order to pass through biological...

established. Idebenone is well absorbed from the gut but undergoes excessive first pass metabolism in the liver, so that less than 1% reach the circulation. This...

gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to...

first-pass effect. Less than 20% is eliminated by renal excretion. Ethylenediamine-derived antihistamines are the oldest of the five classes of first-generation...

the distal one-third of the rectum at least partially avoid the "first pass effect" through the liver, which allows for greater bio-availability of many...

Dunning–Kruger effect is a cognitive bias in which people with limited competence in a particular domain overestimate their abilities. It was first described...

The Butterfly Effect is a 2004 American science fiction thriller film written and directed by Eric Bress and J. Mackye Gruber. It stars Ashton Kutcher...

mucosa bypass gastrointestinal enzymatic degradation and hepatic first-pass effect", prescribing buccal tablets is increasingly common among healthcare...

In chaos theory, the butterfly effect is the sensitive dependence on initial conditions in which a small change in one state of a deterministic nonlinear...

generated whenever a current is passed through a conductive material, is not generally termed a thermoelectric effect. The Peltier–Seebeck and Thomson...

wavelength filters as short-pass and long-pass to avoid confusion, which would correspond to high-pass and low-pass frequencies. Low-pass filters exist in many...

absorbed after oral administration and is subject to a pronounced first-pass effect. The conversion of tilidine into the more active metabolite nortilidine...

intake slows down absorption, but does not decrease it. Due to its first-pass effect, bioavailability is lower: about 24–30% according to different sources...

reaches the systemic circulation unchanged, due to a substantial first-pass effect. Bromocriptine reaches mean peak plasma levels after about 1–1.5 hours...

P-glycoprotein) moving the substance back into the lumen. Combined with a high first-pass effect, this results in an oral bioavailability of about 4.7% with a 100 mg...

commanding position, although still needing majority support to pass a bill. Under first-past-the-post, a small party may draw votes and seats away from...

disorders Tardive dyskinesia, a serious and sometimes irreversible side effect of long-term use of many antipsychotics, mainly typical antipsychotics Hemiballismus...

statistical claim, and it is the first item (magnitude) in the MAGIC criteria. The standard deviation of the effect size is of critical importance, since...

The Doppler effect (also Doppler shift) is the change in the frequency of a wave in relation to an observer who is moving relative to the source of the...