Zinc finger protein GLI3 is a protein that in humans is encoded by the GLI3 gene. This gene encodes a protein that belongs to the C2H2-type zinc finger...

activity of Gli 2 and Gli3, which promote ventral and dorsal neuronal subtypes in the ventral spinal cord. Evidence from Gli3 and SHH/Gli3 mutants show that...

factors that are essential for limb development: Gli1, Gli2 and Gli3. Without Shh, Gli2 and Gli3 are processed to a repressor form and travel to the nucleus...

that control this craniofacial development. Of these genes, DCHS2, RUNX2, GLI3, PAX1 and PAX3 were found to determine nasal morphology, whereas EDAR impacts...

not require Shh. Shh cleaves the Ci/Gli3 transcriptional repressor complex to convert the transcription factor Gli3 to an activator which activates the...

Schinzel in 1979. Mutations in KIF7 are causative for ACLS, and mutations in GLI3 are associated with a similar syndrome. Acrocallosal syndrome (ACLS, ACS...

activator and N-terminal repressor regions have been identified in both Gli2 and Gli3. However, the N-terminal part of human Gli2 is much smaller than its mouse...

condition related to chromosome 7. Mutations in the GLI3 gene cause Greig cephalopolysyndactyly syndrome. The GLI3 gene provides instructions for making a protein...

clusters are reported leading to polydactyly. Interactions of Hoxd13 and GLI3 induce synpolydactyly, a combination of extra and consolidated digits. Other...

unclear. By mutating the proteins Gli2 and Gli3, which were especially studied, it was found that Gli2 and Gli3 contain both activation and repression domains...

Gli3 zinc finger transcription factor has been shown to play a role as a regulator of Emx1. In Gli3 Extra-toes mutants, the transcription factor Gli3...

Syndrome occurs due to a mutation in the GLI3 gene that overrides normal genetic development. Before birth the GLI3 gene delivers directions for protein creation...

transcription factors (Process "5"): the activators Gli1 and Gli2 and the repressor Gli3. The sequence of molecular events that connect SMO to GLIs is poorly understood...

a North-American bus carrier Volkswagen GLI, an automobile GLI1, GLI2, GLI3, glioma-associated family of transcription factors This disambiguation page...

OMIM Gene(s) Systems/organs affected Acrocallosal syndrome 200990 KIF7, GLI3 Acromelic frontonasal dysostosis 603671 ZSWIM6 Arima syndrome 243910 Biemond...

anterior elements reduction by modifying gene networks involving 5'Hox, Gli3, and Shh". Developmental Biology. 413 (1): 1–7. doi:10.1016/j.ydbio.2016...

DLSS RREILSRRPSYRKILNDLSSDAP CREBaB6 E AILA ELKK CREB-mutant binding to KIX Gli3 D DVVQ YLNS TAD homology to CREB/KIX Gal4 D DVYN YLFD Pdr1 and Oaf1 homolog...

(19 May 2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications. 7 (1):...

ENSG00000074047 C2H2 ZF Known motif – High-throughput in vitro [304] GMCCACMCANVNHB GLI3 ENSG00000106571 C2H2 ZF Known motif – High-throughput in vitro [305] VGACCACCCACVNHG...

anteroposterior polarity of the limb. It does this by working in conjunction with Gli3 and dHand to restrict the expression of Sonic Hedgehog (SHh) to the posterior...

Smoothened receptor. Activated smoothened in turn causes Gli1, Gli2, and Gli3 to be translocated into the nucleus where they activate target genes such...

zone of polarizing activity in the limb, which creates a gradient of active Gli3, which activates Gremlin, which inhibits BMPs also secreted in the limb,...

et al. (May 2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications. 7: 11616...

Gómez-Valdés, J. (2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications. 7: 11616...

cells, through its direct target hedgehog pathway transcription factor, Gli3. Many miRNAs can directly target and inhibit cell cycle genes to control...

Chacón-Duque (2016). "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation". Nature Communications. 7 (1):...

to activation of the Gli family of transcription factors (GLI1, GLI2, and GLI3). In this context Shh acts as a morphogen - it induces cell differentiation...

unknown brain None None unknown None GLI3, COL5A3 Astro_54 unknown unknown brain None None unknown None F11-AS1, ETNPPL, GLI3, OBI1-AS1 Astro_55 unknown unknown...

the fetus examines disruptions in the HOXD13 gene at 2q31-q32 and in the GLI3 gene at 7p13. These genomic regions regulate proliferation and differentiation...

HGNC:4316 Q92896 6286 GLI1 HGNC:4317 P08151 6287 GLI2 HGNC:4318 P10070 6288 GLI3 HGNC:4319 P10071 6289 GLI4 HGNC:4320 P10075 6290 GLIPR1 HGNC:17001 P48060...