• Thumbnail for G protein
    G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved...
    24 KB (2,739 words) - 13:21, 17 February 2024
  • Thumbnail for G protein-coupled receptor
    G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors...
    82 KB (9,376 words) - 08:31, 7 March 2024
  • Protein A/G is a recombinant fusion protein that combines IgG binding domains of both protein A and protein G. Protein A/G contains four Fc binding domains...
    3 KB (359 words) - 16:13, 20 December 2023
  • Thumbnail for Respiratory syncytial virus
    and G proteins, F fusion occurs independently of G. F protein exists in multiple conformational forms. In the prefusion state (PreF), the protein exists...
    102 KB (10,070 words) - 07:07, 11 May 2024
  • Thumbnail for Heterotrimeric G protein
    Heterotrimeric G protein, also sometimes referred to as the "large" G proteins (as opposed to the subclass of smaller, monomeric small GTPases) are membrane-associated...
    13 KB (1,237 words) - 18:10, 26 April 2024
  • Protein G is an immunoglobulin-binding protein expressed in group C and G streptococcal bacteria much like protein A but with differing binding specificities...
    5 KB (549 words) - 16:14, 20 December 2023
  • ligand-stimulated G protein-coupled receptors (GPCRs). GPCRs in turn release activated G-protein βγ- subunits (Gβγ) from inactive heterotrimeric G protein complexes...
    9 KB (804 words) - 23:15, 23 May 2023
  • of proteins is a member of the Ras superfamily of small G proteins. Approximately 70 types of Rabs have now been identified in humans. Rab proteins generally...
    12 KB (1,327 words) - 12:48, 10 May 2024
  • including ions (e.g. Na+, K+, Ca++, etc.), lipids (e.g. steroid, prostaglandin), peptides (e.g. insulin, ACTH), carbohydrates, glycosylated proteins (proteoglycans)...
    62 KB (6,780 words) - 04:09, 31 March 2024
  • Thumbnail for G protein-coupled receptor kinase
    G protein-coupled receptor kinases (GPCRKs, GRKs) are a family of protein kinases within the AGC (protein kinase A, protein kinase G, protein kinase C)...
    18 KB (2,053 words) - 10:43, 23 March 2024
  • Thumbnail for Protein poisoning
    energy needs from protein leads to health problems. They suggested an upper limit of 25% or 2-2.5 g/kg, "corresponding to 176 g protein per day for an 80...
    12 KB (1,397 words) - 18:07, 14 April 2024
  • Thumbnail for Receptor (biochemistry)
    Receptor proteins can be classified by their location. Cell surface receptors, also known as transmembrane receptors, include ligand-gated ion channels, G protein-coupled...
    26 KB (2,672 words) - 18:09, 25 April 2024
  • Thumbnail for G protein-gated ion channel
    G protein-gated ion channels are a family of transmembrane ion channels in neurons and atrial myocytes that are directly gated by G proteins. Generally...
    30 KB (3,706 words) - 21:03, 30 December 2023
  • Thumbnail for Protein
    Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions...
    87 KB (9,875 words) - 00:02, 21 April 2024
  • required to make the functional protein. As the largest and most diverse family of receptors within the human genome, G protein-coupled receptors (GPCR) have...
    13 KB (1,372 words) - 08:00, 3 May 2024
  • binding and hydrolysis takes place in the highly conserved P-loop "G domain", a protein domain common to many GTPases. GTPases function as molecular switches...
    20 KB (2,306 words) - 10:38, 3 December 2023
  • Thumbnail for Protein quaternary structure
    Protein quaternary structure is the fourth (and highest) classification level of protein structure. Protein quaternary structure refers to the structure...
    21 KB (2,342 words) - 01:23, 21 April 2024
  • GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to activated G proteins and stimulate...
    16 KB (2,237 words) - 12:24, 27 August 2023
  • Thumbnail for Phosphatidylinositol 4,5-bisphosphate
    A G protein-coupled receptors (GPCRs) via direct binding, and enhance their selectivity toward certain G proteins. PIP2 has been shown to recruit G protein-coupled...
    20 KB (2,042 words) - 08:24, 26 March 2024
  • Thumbnail for Regulator of G protein signaling
    Regulators of G protein signaling (RGS) are protein structural domains or the proteins that contain these domains, that function to activate the GTPase...
    9 KB (994 words) - 11:23, 18 August 2023
  • Thumbnail for Signal transduction
    events. Most commonly, protein phosphorylation is catalyzed by protein kinases, ultimately resulting in a cellular response. Proteins responsible for detecting...
    63 KB (7,624 words) - 03:29, 26 January 2024
  • Thumbnail for GPER
    G protein-coupled estrogen receptor 1 (GPER), also known as G protein-coupled receptor 30 (GPR30), is a protein that in humans is encoded by the GPER...
    38 KB (4,218 words) - 04:33, 11 May 2024
  • Thumbnail for Protein kinase A
    intracellular heterotrimeric G protein complex by protein domain dynamics. The Gs alpha subunit of the stimulated G protein complex exchanges GDP for GTP...
    27 KB (2,665 words) - 17:03, 6 April 2024
  • Thumbnail for Inverse agonist
    have been identified, as have drugs at ligand gated ion channels and at G protein-coupled receptors. An example of a receptor site that possesses basal...
    11 KB (1,120 words) - 05:43, 29 February 2024
  • Thumbnail for Cell surface receptor
    polypeptide chains cross the lipid bilayer once, while others, such as the G-protein coupled receptors, cross as many as seven times. Each cell membrane can...
    21 KB (2,456 words) - 22:14, 21 November 2023
  • Thumbnail for Human metapneumovirus
    specifically the epithelial cells of the respiratory tract, using the G protein. This G protein contains a hydrophobic region that acts as an uncleaved signal...
    37 KB (4,348 words) - 23:18, 16 April 2024
  • Thumbnail for Alfred G. Gilman
    Prize in Physiology or Medicine "for their discovery of G-proteins and the role of these proteins in signal transduction in cells." Gilman was the son of...
    35 KB (3,668 words) - 11:39, 8 April 2024
  • s ( g ) P r o t e i n   i n t a k e ( g ) {\displaystyle PER\,={\frac {Gain\ in\ body\ mass(g)}{Protein\ intake(g)}}} Protein (nutrient) Protein Digestibility...
    3 KB (298 words) - 11:21, 28 March 2022
  • Thumbnail for Beta-1 adrenergic receptor
    ADRB1, can refer to either the protein-encoding gene (gene ADRB1) or one of the four adrenergic receptors. It is a G-protein coupled receptor associated...
    31 KB (3,747 words) - 03:23, 19 March 2024
  • messengers. In the case of G protein-coupled receptors, the conformation change exposes a binding site for a G-protein. The G-protein (named for the GDP and...
    12 KB (1,338 words) - 08:26, 24 July 2023